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Icaritin-loaded calcium phosphate ceramic scaffold with surface micro-nano structure, and preparation method and use thereof

A technology of calcium phosphate ceramics and micro-nano structure, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of lack of osteoinductive properties, unsatisfactory repair effect of bone defect, poor repair effect of bone defect, etc. , to achieve the effects of easy industrialization, good osteoinductivity, and good bone repair ability

Pending Publication Date: 2020-07-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Icaritin can obviously promote the formation of blood vessels, inhibit bone resorption and improve the regeneration ability of bone tissue. Therefore, as a drug loaded into the bone repair scaffold, although it can promote bone formation to a certain extent, it has no effect on the repair of bone defects. It is still not ideal and needs to be further improved; at the same time, bone repair materials containing icariin do not have osteoinductive properties, and the repair effect on bone defects that have lost osteogenic properties is poor

Method used

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  • Icaritin-loaded calcium phosphate ceramic scaffold with surface micro-nano structure, and preparation method and use thereof
  • Icaritin-loaded calcium phosphate ceramic scaffold with surface micro-nano structure, and preparation method and use thereof
  • Icaritin-loaded calcium phosphate ceramic scaffold with surface micro-nano structure, and preparation method and use thereof

Examples

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Embodiment 1

[0048] Embodiment 1, the preparation of the calcium phosphate drug-loaded stent loaded with icariin of the present invention

[0049] (1) Using deionized water as a solvent, 360g calcium hydroxide is made into 3500mL suspension, the stirring speed is 1250rpm, and 370g phosphoric acid is made into 2500mL solution; the phosphoric acid solution is added dropwise into calcium hydroxide at a speed of 50mL / min In the suspension, the stirring speed was 1250rpm. After the dropwise addition was completed, the reaction was left at room temperature for 2 hours. After the reaction is completed, filter, dry the filter residue, pulverize with a pulverizer, and ball mill with a ball mill until the particle diameter is 250 μm to obtain tricalcium phosphate powder.

[0050] (2) Weigh 200g of tricalcium phosphate powder, add 400mL of deionized water, ball mill at 150rpm for 30min, repeat 2 times. Weigh the slurry, add hydrogen peroxide according to the weight of the slurry until the concentrat...

Embodiment 2

[0056] Embodiment 2, the preparation of the calcium phosphate drug-loaded stent loaded with icariin of the present invention

[0057] (1) Using deionized water as a solvent, make 360g of calcium hydroxide into a 3500mL suspension with a stirring speed of 1250rpm, prepare 370g of phosphoric acid into a 2500mL solution, and add the phosphoric acid solution dropwise into calcium hydroxide at a speed of 50mL / min In the suspension, the stirring speed was 1250rpm. After the dropwise addition was completed, the reaction was left at room temperature for 2 hours. After the reaction is completed, filter, dry the filter residue, pulverize with a pulverizer, and ball mill with a ball mill until the particle diameter is 250 μm to obtain tricalcium phosphate powder.

[0058] (2) Weigh 200g of tricalcium phosphate powder, add 400mL of deionized water, ball mill at 150rpm for 30min, repeat 2 times. Weigh the slurry, add hydrogen peroxide according to the weight of the slurry until the hydrog...

Embodiment 3

[0062] Embodiment 3, the preparation of the calcium phosphate drug-loaded stent loaded with icariin of the present invention

[0063] (1) Using deionized water as a solvent, 360g of calcium hydroxide was made into 3500mL suspension, the stirring speed was 1250rpm, 370g of phosphoric acid was made into 2500mL solution, and the phosphoric acid solution was added dropwise into calcium hydroxide at a speed of 100mL / min In the suspension, the stirring speed was 1250rpm. After the dropwise addition was completed, the reaction was left at room temperature for 2 hours. After the reaction is completed, filter, dry the filter residue, pulverize with a pulverizer, and ball mill with a ball mill until the particle diameter is 200 μm to obtain tricalcium phosphate powder.

[0064] (2) Weigh 200g of tricalcium phosphate powder, add 400mL of deionized water, ball mill at 150rpm for 30min, repeat 2 times. Weigh the slurry, add hydrogen peroxide according to the weight of the slurry until the...

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Abstract

The invention provides an icaritin-loaded calcium phosphate ceramic scaffold with a surface micro-nano structure, and a preparation method and use thereof, and belongs to the field of biomedical materials. The calcium phosphate ceramic scaffold is obtained by immersing a calcium phosphate ceramic with a micro-nano structure on the surface into an icaritin solution for chelation. A preparation method of the calcium phosphate ceramic comprises adding hydrogen peroxide and polyvinyl alcohol into tricalcium phosphate slurry and performing uniform mixing to obtain slurry, and sintering the slurry at 1000-1050 DEG C. The calcium phosphate drug-loaded scaffold of the invention has a perforated porous structure, and is beneficial to the transportation of blood, cells and substances; and at the same time, has the good bone repair ability. Most importantly, the surface of the scaffold has a special micro-nano structure, so that the scaffold has good bone inducibility, and the problem that a calcium phosphate scaffold in the prior art only has bone conduction properties is solved. In addition, the calcium phosphate drug-load scaffold has low biological toxicity, simple preparation process, low cost, and easily-realized industrialization, and has broad application prospects in the bone defect repair aspect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an icariin-loaded calcium phosphate ceramic support with a surface micro-nano structure and a preparation method and application thereof. Background technique [0002] As a hard tissue, bones frame the basic shape of the human body. The special construction of the skeletal system enables movement and provides support and protection for other vital tissues / organs. Injuries and lesions of the skeletal system greatly hinder the normal activities of the human body and significantly reduce the quality of life. Therefore, it is very important to ensure the health of the skeletal system, and the treatment of skeletal diseases and the repair of bone injuries have also been widely concerned by the society. [0003] Although bone has a certain regeneration function, for example, fracture will trigger the whole process of bone injury healing (inflammation, angiogenesis, bon...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/54A61L27/56
CPCA61L27/46A61L27/54A61L27/56A61L2300/216A61L2300/412A61L2430/02C08L29/04
Inventor 吕国玉彭海涛
Owner SICHUAN UNIV