Sitagliptin phosphate tablet

A technology of sitagliptin phosphate tablets and sitagliptin phosphate, which is applied in the direction of pill delivery, medical preparations of non-active ingredients, endocrine system diseases, etc., can solve problems such as inapplicability of flavoring agents, and achieve rapid dissolution and increase Good compliance and disintegration

Inactive Publication Date: 2020-08-04
千辉药业(安徽)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For diabetic patients, commonly used flavoring agents such as aspartame, sodium cyclamate, stevia, sucrose, and sodium glutamate are not suitable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A kind of sitagliptin phosphate tablet, comprises pharmaceutically active component sitagliptin phosphate and auxiliary material, and the mass ratio of pharmaceutically active component sitagliptin phosphate and auxiliary material is 8.5-90; Said auxiliary material comprises the raw material of following weight portion: 30 parts of microcrystalline cellulose, 40 parts of dextrin, 25 parts of disintegrant, 10 parts of flavoring agent, 7 parts of binder, 4 parts of lubricant and 3 parts of stabilizer.

[0021] Described disintegrant is sodium carboxymethyl starch;

[0022] The flavoring agent microcrystalline fruit powder;

[0023] Described binding agent is cornstarch;

[0024] Described lubricant is silicon dioxide;

[0025] Described stabilizer is zinc stearate.

Embodiment 2

[0027] A kind of sitagliptin phosphate tablet, comprises pharmaceutically active component sitagliptin phosphate and auxiliary material, and the mass ratio of pharmaceutically active component sitagliptin phosphate and auxiliary material is 10:90; Described auxiliary material comprises the raw material of following weight portion: 40 parts of microcrystalline cellulose, 30 parts of dextrin, 30 parts of disintegrant, 15 parts of flavoring agent, 4 parts of binder, 4 parts of lubricant and 5 parts of stabilizer.

[0028] The disintegrant is low-substituted hydroxypropyl cellulose;

[0029] The flavoring agent microcrystalline fruit powder;

[0030] Described binding agent is gelatin;

[0031] Described lubricant is talcum powder;

[0032] Described stabilizer is calcium stearate.

Embodiment 3

[0034] A kind of sitagliptin phosphate tablet, comprises pharmaceutically active component sitagliptin phosphate and auxiliary material, and the mass ratio of pharmaceutically active component sitagliptin phosphate and auxiliary material is 11:90; Described auxiliary material comprises the raw material of following weight portion: 50 parts of microcrystalline cellulose, 20 parts of dextrin, 25 parts of disintegrant, 14 parts of flavoring agent, 6 parts of binder, 6 parts of lubricant and 4 parts of stabilizer.

[0035] Described disintegrant is croscarmellose sodium;

[0036] The flavoring agent microcrystalline fruit powder;

[0037] Described binding agent is polyethylene glycol;

[0038] Described lubricant is talcum powder;

[0039] Described stabilizer is calcium stearate.

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PUM

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Abstract

The invention discloses a sitagliptin phosphate tablet, which comprises a pharmaceutical active component sitagliptin phosphate and auxiliary materials. The mass ratio of the pharmaceutical active component sitagliptin phosphate to the auxiliary materials is 8.5-11.2: 90. The auxiliary materials comprise the following raw materials in parts by weight: 30-50 parts of microcrystalline cellulose, 20-40 parts of dextrin, 25-40 parts of a disintegrating agent, 10-15 parts of a flavoring agent, 4-7 parts of an adhesive, 4-8 parts of a lubricating agent and 3-5 parts of a stabilizing agent. Comparedwith common tablets, the sitagliptin phosphate tablet has the advantages of rapid dissolution, good disintegration; by means of low temperature freeze drying of the fruit juice, the nutrients are notdestroyed; the prepared microcrystalline fruit powder replaces sucrose and other flavoring agents; the product is suitable for diabetic patients and has natural and appropriate mouthfeel; and with thefruit aroma, the bitter and astringent smell of the above obtained medicine is completely covered, and the medication compliance is increased.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a sitagliptin phosphate tablet. Background technique [0002] Sitagliptin phosphate can increase the secretion of insulin in a blood glucose-dependent manner, and its hypoglycemic effect is relatively moderate. It will not cause hypoglycemia, and has no side effects such as weight gain, nausea, and vomiting. The mechanism of action is a DPP-IV inhibitor, which can relatively increase the level of naturally occurring incretins, including insulin-like peptide-1 and glucose-dependent insulinotropic peptide, by inhibiting enzyme activity, thereby triggering pancreatic islets to increase insulin production And make the liver stop glucose production, and finally reduce the clinical effect of blood sugar concentration. Due to its low price and wide clinical application, the market demand is relatively large. [0003] For diabetic patients, commonly used flavoring agents such as aspa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4985A61K47/46A61P5/50
CPCA61K9/2068A61K31/4985A61P5/50
Inventor 孙学喜杨会来毛杰
Owner 千辉药业(安徽)有限责任公司
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