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CsA carried hydrogel for burn wound healing, and preparation method thereof

A wound healing and hydrogel technology, applied in medical science, bandages, etc., can solve the problems of being unable to resist bacterial invasion, failing to achieve hydrogel, not having antibacterial properties, etc., and achieving antimicrobial and anti-pollution properties, good Ease of cleaning, good self-healing performance

Inactive Publication Date: 2020-09-11
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, after the hydrogel is placed on the wound, the movement of body muscles can easily lead to damage or even rupture of the colloid, which increases the risk of infection, and also destroys the structure of the hydrogel and affects its function.
In addition, the hydrogel itself is not antibacterial and cannot resist the invasion of bacteria, so there is a risk of infection
After long-term use of hydrogel, the hydrogel swells due to its strong water absorption capacity, and it is poorly attached to the wound surface
In addition, the ideal hydrogel applied to burn wounds needs to meet higher requirements: self-repairing dressing damage, with strain resistance; carrying some drugs to prevent wound infection, with antibacterial properties; state can be changed, with long-term fit ; Release some kind of drug that promotes wound healing; however, there is no hydrogel that can achieve the above characteristics in clinical practice

Method used

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  • CsA carried hydrogel for burn wound healing, and preparation method thereof
  • CsA carried hydrogel for burn wound healing, and preparation method thereof
  • CsA carried hydrogel for burn wound healing, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A burn wound healing hydrogel carrying cyclosporine A, the structural formula of which is as follows:

[0031]

[0032] The preparation method of the hydrogel refers to the method in "ACS applied materials&interfaces. 2017; 9(11):9221-9225", specifically: (1) N-isopropylacrylamide monomer and polyethylene glycol The monomer adopts RAFT polymerization method to synthesize the copolymer; (2) then replace the active ester in the copolymer obtained in step (1) with the dopamine group; (3) add mercaptoethylamine to the result of step (2) for chemical grafting reaction to obtain the hydrogel. The number average molecular weight of the polyethylene glycol is 2000-6000, and the mass ratio of the polyethylene glycol monomer to the N-isopropylacrylamide monomer is 1-2:2-1.

experiment example 1

[0034] To construct a severe burn model in rats, the hydrogel obtained in Example 1 (with the mass ratio of polyethylene glycol monomer and N-isopropylacrylamide monomer being 1:1 as an example) was equipped with CsA and silver nanoparticles to prepare Form a hydrogel dressing, investigate the protective effect of the obtained hydrogel dressing of embodiment 1 for the local tissue recovery of rats after burns and the inhibitory effect of systemic inflammatory response, its method is as follows:

[0035] Take 40 rats and divide them into 4 groups, control group (Control), model group (Burn), positive control group (Burn+Intrasite Gel), and experimental group (Burn+HydrogelA). All rats were shaved on the back, and carried out general anesthesia with 1% pentobarbital sodium 1mL intraperitoneal injection, taking the area as 30% of the total surface area (TBSA=K*W*0.5, K=0.9, W is the weight of the mouse) as burn area. All rats except the control group were anesthetized and scalde...

experiment example 2

[0041] The hydrogel prepared in "ACS applied materials&interfaces.2017; 9(11):9221-9225" was used in the severe burn model of rats mentioned above, which was recorded as the positive control group 2, and the results were shown in Table 2 by loading CsA:

[0042] Table 2

[0043]

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PUM

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Abstract

The invention provides CsA carried hydrogel for burn wound healing. The hydrogel is an ABA type tri-block net-shaped copolymer constituted through polymerization of polyethylene glycol and an N-isopropylacrylamide monomer, wherein the copolymer comprises mussel bionic tissue bounding groups and silver nano-particle anchoring groups, and CsA is carried on the surface of and inside the hydrogel. Thehydrogel prepared is high in adaptability, biocompatibility, adhesiveness, thermal sensitivity, injectable nature, microbial resistance and the like. The hydrogel can realize effective sol-gel conversion at a low temperature or a room temperature, the hydrogel also has good self-repair performance and has a good anti-microbial effect towards common E-coli bacteria and can realize obvious anti-sticking and self-cleaning effects towards skin cells. A dressing made through carrying of CsA on the hydrogel can accelerate healing of a full-layer burn wound, reduce in-vivo inflammatory factor release, promote granulation tissue growth, etc.

Description

technical field [0001] The invention belongs to the technical field of hydrogel materials, and in particular relates to a hydrogel for healing burn wounds loaded with cyclosporin A and a preparation method thereof. Background technique [0002] Burn is a kind of tissue damage caused by various heat sources including hot liquid, high-temperature gas, flame, red-hot metal, chemical substances, etc., and mainly occurs in surface tissues such as skin and mucous membranes. After severe burns, in addition to regional local skin and mucous membrane damage, the following reactions may also occur: increased metabolism, decreased body temperature, excessive water loss, massive loss of protein, and disorders of the endocrine and immune systems. The exposed burn wounds, in addition to causing the body's fluid balance disorder and the destruction of the defense barrier in a short period of time, the wounds that do not heal for a long time will also become a breeding ground for bacterial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0004A61L26/0066A61L26/008A61L26/0061A61L2300/104A61L2300/252A61L2300/404C08L87/005
Inventor 刘睿奇
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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