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Application of berberine-oryzanol tablet in treatment of diabetes

A technology of berberine hydrochloride and oryzanol, which is applied in the field of medicine, can solve the problems of low bioavailability and drug dissolution, achieve the effects of simple prescription and preparation process, increase specific surface area, and improve bioavailability

Active Publication Date: 2020-09-22
YICHUN WANSHEN PHARMA MACHINERY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of the two into a compound preparation not only has to overcome the problems of low dissolution rate and low bioavailability of the drug, but at the same time, the properties of different drug raw materials are different, and the preparation of them in the same preparation will inevitably face technical difficulties such as the selection of excipients.

Method used

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  • Application of berberine-oryzanol tablet in treatment of diabetes
  • Application of berberine-oryzanol tablet in treatment of diabetes
  • Application of berberine-oryzanol tablet in treatment of diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of berberine hydrochloride oryzanol tablet, its composition is as follows:

[0032]

[0033] Preparation:

[0034] (1) Preparation of berberine hydrochloride oryzanol granules

[0035] Mix berberine hydrochloride, oryzanol, polysorbate 80, and hypromellose, jet mill, and dry granulate. The added polysorbate 80 and the added hypromellose were dissolved in 3% hydroxyethyl cellulose aqueous solution to obtain a coating solution. The above-mentioned coating liquid is sprayed onto the granules obtained by dry granulation by means of fluidized bed spraying, and the weight gain of the coating is 3%, to obtain the berberine hydrochloride oryzanol modified granules.

[0036] (2) Preparation of tablets

[0037] The above-mentioned berberine hydrochloride oryzanol modified granules are mixed with lactose, croscarmellose sodium and magnesium stearate and then compressed into tablets.

Embodiment 2

[0039] A kind of berberine hydrochloride oryzanol tablet, its composition is as follows:

[0040]

[0041] Preparation:

[0042] (1) Preparation of berberine hydrochloride oryzanol granules

[0043] Mix berberine hydrochloride, oryzanol, sodium lauryl sulfate, and poloxamer, jet mill, and dry granulate. Added sodium lauryl sulfate and added poloxamer were dissolved in 5% aqueous solution of hydroxyethyl methylcellulose to obtain a coating solution. The above-mentioned coating liquid is sprayed onto the granules obtained by dry granulation by means of fluidized bed spraying, and the weight gain of the coating is 3%, to obtain the berberine hydrochloride oryzanol modified granules.

[0044] (2) Preparation of tablets

[0045] The above-mentioned berberine hydrochloride oryzanol modified granules are mixed with lactose, croscarmellose sodium and magnesium stearate and then compressed into tablets.

Embodiment 3

[0047] A kind of berberine hydrochloride oryzanol tablet, its composition is as follows:

[0048]

[0049] Preparation:

[0050] (1) Preparation of berberine hydrochloride oryzanol granules

[0051] Mix berberine hydrochloride, oryzanol, sodium lauryl sulfate, and hypromellose, jet mill, and dry granulate. The added sodium lauryl sulfate and the added hypromellose were dissolved in a 3% aqueous solution of hydroxyethyl methylcellulose to obtain a coating solution. The above-mentioned coating liquid is sprayed onto the granules obtained by dry granulation by means of fluidized bed spraying, and the weight gain of the coating is 3%, to obtain the berberine hydrochloride oryzanol modified granules.

[0052] (2) Preparation of tablets

[0053] The above-mentioned berberine hydrochloride oryzanol modified granules are mixed with microcrystalline cellulose, lactose, crospovidone and magnesium stearate, and then compressed into tablets.

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Abstract

The invention provides a berberine-oryzanol tablet and application thereof in treatment of diabetes. The berberine-oryzanol tablet is obtained through mixing of modified berberine-oryzanol granules and other adjuvants at a certain ratio and tabletting of the mixture, wherein the modified granules comprise drugs, surfactants and dispersants. Through the modified granules, the solubility of berberine and oryzanol can be improved well, and the dissolution and bioavailability of the drugs can be improved. According to the tablet, a good treatment effect on diabetes can be achieved through compatibility of the drugs, a reasonable prescription and preparation process.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a prescription and a preparation process of a berberine hydrochloride oryzanol tablet, and an application of the tablet in medicine for treating diabetes. Background technique [0002] Berberine hydrochloride (berberine, Berberine) is a kind of isoquinoline alkaloid isolated from Coptis chinensis, the main antibacterial active ingredient of Coptis chinensis. It is yellow needle-like crystal with bitter taste. Widely distributed in the plant kingdom. Berberine hydrochloride is commonly used for intestinal infections, [0003] [0004] Oryzanol (OZ) is a vitamin drug extracted from rice bran oil, and its main components are cycloartenol ferulic acid ester and 2,4-methylenecycloartenol ferulic acid ester. my country is a big rice producing country in the world, and the source of raw materials for extracting oryzanol is extremely rich. Oryzanol mainly improves autonomic nervous function,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/20A61K47/26A61K47/38A61K47/10A61K31/4375A61K31/575A61P3/10
CPCA61K9/2081A61K9/2095A61K9/2054A61K9/2013A61K9/2018A61K9/2031A61K31/4375A61K31/575A61P3/10A61K2300/00
Inventor 李琎杰熊洪峰杨春艳
Owner YICHUN WANSHEN PHARMA MACHINERY
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