Rapid pretreatment method for simultaneously detecting glimepiride and metformin in blood plasma
A metformin and blood plasma technology, applied in the field of analysis, can solve the problems of long analysis time and complicated operation, and achieve the effects of low matrix interference, high sensitivity, and simplified sample processing steps
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[0034] This example involves the simultaneous enrichment and detection of glimepiride and metformin in plasma samples by magnetic mesoporous graphene composite materials modified by sulfonic acid groups:
[0035] 1) Synthesis of magnetic mesoporous graphene composites modified with sulfonic acid groups:
[0036] (1) Weigh 300mg of graphene, add 100ml of concentrated nitric acid, place in a 60°C water bath, mechanically stir and react for 6 hours, cool to room temperature, wash with deionized water several times until neutral, and dry for later use;
[0037] (2) Get the acidified graphene 150mg prepared in (1) step, add ferric chloride hexahydrate 405mg, trisodium citrate 150mg, PEG-20000 1.0g, anhydrous sodium acetate 1.8g successively, ultrasonically disperse in 40ml ethyl alcohol In diol, react at 200°C for 10-12 hours, after cooling to room temperature, wash with water and absolute ethanol several times, and dry in vacuum for later use;
[0038](3) Get the magnetic graphen...
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