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Microneedle patch with programmable release of psoriasis treatment drug and preparation method thereof

A technology for the treatment of drugs and psoriasis, which is applied in the field of microneedle patch and its preparation, can solve the problems of uneven drug distribution, reduction, and inability to meet the long-term treatment needs of moderate to severe patients, and achieve rapid onset of effect, improvement of Effects of uniform, rapid and long-acting psoriasis treatments

Active Publication Date: 2021-12-03
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the rapid metabolism of psoriasis drugs in the skin, it cannot meet the long-term treatment needs of moderate to severe patients
[0005] The inventors of the present invention have previously obtained a polymer composite microneedle with programmable drug release and its preparation (see Chinese patent document CN108245482A), although it also discloses a polymer composite microneedle with programmable drug release Microneedles, but because the needle tip part remains in the skin as a whole for sustained release, the drug concentration released by it gradually decreases from the part near the needle tip to the edge part, and the drug distribution is uneven

Method used

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  • Microneedle patch with programmable release of psoriasis treatment drug and preparation method thereof
  • Microneedle patch with programmable release of psoriasis treatment drug and preparation method thereof
  • Microneedle patch with programmable release of psoriasis treatment drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Include the following steps:

[0033] 1. Use a laser engraving machine to etch out a 10*10 polydimethylsiloxane (PDMS) negative template with a bottom diameter of 200 μm, a height of 850 μm, and a distance between adjacent microneedles of 600 μm;

[0034] 2. Prepare a mixed solution of 10 mg / mL methotrexate and 5 mg / mL poly(lactide-co-glycolide) in chloroform, then pass through the membrane with a 0.45 μm filter membrane to obtain a coated Nanoparticles of methotrexate (in these nanoparticles, the poly(lactide-co-glycolide) component is outside and the methotrexate component is encapsulated); the size of the nanoparticles is directly affected by the pore size of the filter membrane , the pore size of the filter membrane can be adjusted according to the actual needs of the particle size; the methotrexate used in this step corresponds to the psoriasis drug that can be slowly released in subsequent applications, and the methotrexate used The specific concentration and vol...

Embodiment 6

[0040] The microneedles prepared in the above-mentioned Example 1 were used on severe psoriasis model mice, and a microneedle patch of a 10*10 array was used every 3 days, and the therapeutic effect was observed after 3 weeks for liver toxicity (alanine aminotransferase , aspartate aminotransferase levels). image 3 The results (Ki67) of middle tissue section (H&E staining) and skin lesion thickening expression factor show that the present invention has obvious curative effect to the ear skin lesion of treatment psoriasis mouse; Figure 4 The levels of the two enzymes (alanine aminotransferase ALT, aspartate aminotransferase AST) in the liver of the mice did not change significantly compared with those of normal mice without disease, indicating that the present invention has no obvious liver toxicity.

[0041] The "poorly soluble", "soluble" and "easy soluble" in the present invention meet the conventional definitions.

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Abstract

The invention belongs to the field of biomedical polymer materials, and discloses a microneedle patch which can be programmed to release psoriasis therapeutic drugs and a preparation method thereof. The biocompatible matrix of the drug, and the polymer particles that can slowly release the psoriasis drug on the surface and / or inside of the biocompatible matrix; wherein, the matrix material used in the biocompatible matrix is ​​easy Soluble or soluble matter, the biocompatible matrix has independently existing psoriasis drug ingredients for rapid dissolution and release; the polymer particles are insoluble polymer particles mixed with psoriasis drug ingredients, using The effect of the poorly soluble polymer can make the psoriasis drug composition in the polymer particle be released slowly. The invention closely revolves around the drug requirements for psoriasis treatment, and can effectively realize the programmed release of psoriasis treatment drugs by improving the internal structure and composition of the microneedles.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a microneedle patch that can programmatically release psoriasis therapeutic drugs and a preparation method thereof. The drug alleviates the psoriatic skin lesions, and at the same time, the slow-release particles are left in the skin to maintain a long-term effective drug treatment effect. Background technique [0002] Psoriasis is a common chronic inflammatory skin disease. The typical symptom is erythema on the skin covered with silvery white scales. The disease recurs and seriously affects the life and psychological status of patients. At present, no effective cure for psoriasis has been found, and only symptomatic and supportive therapy can be used to alleviate the condition. [0003] Methotrexate (MTX), cyclosporine, tretinoin, azathioprine, hydroxyurea, leflunomide, mycophenolate mofetil, glucocorticoids, and anti-tumor necrosis factor-alpha (ant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K45/00A61M37/00A61P17/06
CPCA61K9/0021A61K45/00A61M37/0015A61M2037/0046A61M2037/0053A61P17/06
Inventor 柳佩毕舵航王华朱锦涛张连斌陶娟
Owner HUAZHONG UNIV OF SCI & TECH
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