Zinc-containing artificial bone and preparation method thereof

A technology of artificial bone and technology, applied in the medical field, can solve the problems of difficult bone repair in load-bearing parts, poor osteoinductivity of artificial bone, poor mechanical strength of artificial bone, etc., achieve good bone-promoting performance, solve poor osteoinductivity, good reliability The effect of biodegradation

Active Publication Date: 2020-11-24
西安点云生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The object of the present invention is to provide a zinc-containing artificial bone for bone tissue repair and its preparation method, which solves the problems of poor osteoinductivity and poor osteogenic perfor

Method used

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  • Zinc-containing artificial bone and preparation method thereof
  • Zinc-containing artificial bone and preparation method thereof
  • Zinc-containing artificial bone and preparation method thereof

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preparation example Construction

[0048] The invention provides a preparation method of the zinc-containing artificial bone, which is prepared through a process of additive manufacturing (3D printing). The preparation method of the additive manufacturing (3D printing) may be a wireless extrusion 3D printing process, a powder coating 3D printing process or a photocuring 3D printing process. All of them can prepare the zinc-containing artificial bone described in this patent through proper selection of binder and adjustment of process method.

[0049] The preparation method of the wireless extrusion 3D printing zinc-containing artificial bone is as follows:

[0050] (1) Paste preparation: weigh the bioceramic powder and the zinc-containing powder in proportion and mix them evenly to obtain a solid material, and dilute the high molecular polymer binder into an aqueous solution of a certain concentration to obtain a liquid material. The solid material and the liquid material are mixed and stirred evenly, and then...

Embodiment 1

[0072] Embodiment 1 contains the preparation of pure zinc artificial bone (wireless extrusion)

[0073] (1) The bioceramic material is selected as a mixed powder of β-tricalcium phosphate (β-TCP) and hydroxyapatite (HA), and the mixing ratio of the two is 3.5:1. Powder particle size 10μm-20μm. The zinc-containing component is selected as pure zinc powder, the purity of which is higher than 99%, and the particle size of the pure zinc powder is 10 μm-20 μm. Select polyvinyl alcohol (PVA) as the polymer binder;

[0074] (2) Ingredients: According to the mass ratio, 10% of pure zinc powder, 84.5% of bioceramic powder (mixed with β-TCP and HA), and 5.5% of polyvinyl alcohol are used as ingredients. Concrete steps Prepare 8g of polyvinyl alcohol and 92g of pure water to make a polyvinyl alcohol aqueous solution with a mass fraction of 8%, place it in a jar with a lid, heat and swell in a water bath at 60°C for 2h, and then place it in a magnetic stirrer at 96°C Stir at 250r / min f...

Embodiment 2

[0082] The preparation of embodiment 2 zinc-magnesium alloy artificial bone (spread powder and spray binder)

[0083] (1) In this embodiment, the bioceramic material is a mixture of calcium magnesium silicate and calcium sulfate, the mixing ratio of the two is 1:1, and the particle size of the powder is 10 μm. The zinc-magnesium binary alloy powder is selected as the zinc-containing component; the magnesium content in the zinc-magnesium alloy is 5% of the total mass fraction of the zinc-magnesium alloy, and the rest is zinc. The particle size of the zinc-magnesium alloy powder is 10 μm. Select phosphoric acid as binder;

[0084] (2) Batching: According to the mass ratio, 15% of zinc-magnesium alloy powder, 84.5% of the mixture of calcium magnesium silicate and calcium sulfate, and 0.5% of phosphoric acid are used for batching. Use a balance to weigh 150 grams of zinc-magnesium alloy powder in the above ratio, 845 grams of mixed powder of calcium magnesium silicate and calciu...

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Abstract

The invention provides a zinc-containing artificial bone for bone tissue repair and a preparation method thereof. The zinc-containing artificial bone is prepared from the following raw materials in percentage by mass: 0.1-15% of zinc-containing powder, 80-98% of bioceramic powder and 0.5-10% of high-molecular polymer adhesive. The preparation method of the zinc-containing artificial bone comprisesa 3D printing technique. The method solves the problems of poor bone inductivity and poor bone formation promoting property in the traditional bioceramic artificial bone, and solves the problems of poor mechanical strength and difficulty in satisfying the bone repair demands of the bearing part in the traditional bioceramic artificial bone.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to a zinc-containing artificial bone for clinical bone defect repair and a preparation method thereof. Background technique [0002] Bone defect is a common clinical disease in orthopedics. The reason for the defect is severe trauma, joint replacement, bone tumor resection, osteomyelitis, congenital deformity and other orthopedic diseases. The most effective way to treat bone defects is to perform bone graft surgery to repair them. What kind of repair material to use in bone defect repair has always been the research and development direction of clinical medicine and biomaterials. Autologous bone grafting has always been the most ideal bone graft material, but its application is limited due to the limitations of the donor site, secondary surgery, infection, structural damage to the donor site, and residual pain. Allograft bone has the advantages of tissue shape, structure, strength...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/54A61L27/50A61L27/04A61L27/10A61L27/16A61L27/12C04B35/447C04B35/622C04B35/634B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/56A61L27/54A61L27/50A61L27/047A61L27/10A61L27/16A61L27/12C04B35/447C04B35/622C04B35/634B33Y10/00B33Y70/10B33Y80/00B22F3/227A61L2300/102A61L2300/412A61L2430/02C04B2235/3284C04B2235/5436B22F1/105B22F1/10C08L29/04Y02P10/25
Inventor 曾庆丰益明星
Owner 西安点云生物科技有限公司
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