Hydroxyapatite coating with biological activity and hierarchical structure on surface of degradable magnesium-based endosteal implant and preparation method

A hydroxyapatite and coating technology, applied in coating, metal material coating process, tissue regeneration and other directions, can solve the problems of insufficient anti-corrosion protection effect, easy to cause inflammation caused by degradation products, insufficient anti-corrosion ability, etc. Beneficial for adhesion and proliferation, good cytocompatibility and bioactivity, improved corrosion resistance and bioactivity

Active Publication Date: 2020-11-24
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problem that the current brushite coating improves the corrosion resistance of magnesium and magnesium alloy materials, especially high specific area devices, and the degradation products are weakly acidic and easy to cause inflammation. Deposited hydroxyapatite coating has poor bonding strength, thinner or less dense coating, and insufficient corrosion protection effect

Method used

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  • Hydroxyapatite coating with biological activity and hierarchical structure on surface of degradable magnesium-based endosteal implant and preparation method
  • Hydroxyapatite coating with biological activity and hierarchical structure on surface of degradable magnesium-based endosteal implant and preparation method
  • Hydroxyapatite coating with biological activity and hierarchical structure on surface of degradable magnesium-based endosteal implant and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of bioactive hydroxyapatite coating on the surface of Mg-Nd-Zn-Zr alloy bone screws. Specific steps are as follows:

[0040] 1) Firstly, the Mg-Nd-Zn-Zr alloy is made into a Φ14×3mm sample, polished with 320#, 1200#, 3000# water sandpaper in sequence, ultrasonically cleaned with anhydrous ethanol for 5min×2 times, and dried.

[0041] 2) Soak the sample in 40% hydrofluoric acid at 30° C. for 6 hours while shaking on a shaker. Rinse with deionized water and absolute ethanol in turn, and blow dry.

[0042] 3) The fluorinated sample is in NaNO 3 : Ca(H 2 PO 4 ) 2 :H 2 o 2 = 4:3:1 (wt%) calcium-phosphorus solution at room temperature for 6 hours. The precursor brushite DCPD coating was prepared.

[0043] 4) Preparation of hydrothermal reaction liquid: take Ca-EDTA:NaH 2 PO 4 =1:1 (substance ratio), add deionized water to dissolve, then add 1mol / L NaOH solution to adjust pH=9. Soak the fluorinated Mg-Nd-Zn-Zr alloy covered with DCPD coating in the hydr...

Embodiment 2

[0046] Bioactive hydroxyapatite coating was prepared on the surface of ZK60 (Mg-Zn series) alloy bone plate. Specific steps are as follows:

[0047] 1) First, make a Φ14×3mm sample of ZK60 alloy, polish it with 320#, 1200#, 3000# water sandpaper in turn, ultrasonically clean it with absolute ethanol for 5min×2 times, and blow dry.

[0048] 2) Soak the sample in 30% hydrofluoric acid at 20° C. for 12 hours while shaking on a shaker. Rinse with deionized water and absolute ethanol in turn, and blow dry.

[0049] 3) The fluorinated sample is in NaNO 3 : Ca3(PO 4 ) 2 :H 2 o 2 =7:3:2 (wt%) calcium-phosphorus solution at room temperature and soak for 36h. The precursor brushite DCPD coating was prepared.

[0050] 4) Preparation of hydrothermal reaction solution: take Ca-EDTA:Na 2 HPO 4 =1.67:1 (substance ratio), add deionized water to dissolve, then add 1mol / L NaOH solution to adjust pH=6.5. Soak the above-mentioned fluorinated ZK60 alloy covered with DCPD coating in the ...

Embodiment 3

[0053] Preparation of bioactive hydroxyapatite coating on the surface of pure magnesium porous bone tissue engineering scaffolds for tissue engineering. Specific steps are as follows:

[0054] 1) First, make a Φ10×2mm sample of porous pure magnesium, ultrasonically clean it with acetone and absolute ethanol for 5 minutes, and dry it.

[0055] 2) Soak the sample in 20% hydrofluoric acid at 10° C. for 48 hours while shaking on a shaker. Rinse with deionized water and absolute ethanol in turn, and blow dry.

[0056] 3) The fluorinated sample is in NaNO 3 : Ca3(PO 4 ) 2 : CaHPO 4 :H 2 o 2 =5:2:1:1 (wt%) calcium-phosphorus solution at room temperature for 36 hours. The brushite DCPD coating on the surface of porous pure magnesium was prepared.

[0057] 4) Preparation of hydrothermal reaction solution: take Ca-EDTA:Na 3 PO 4 =2:1 (substance ratio), add deionized water to dissolve, then add 1mol / L NaOH solution to adjust pH=8.5. Soak the fluorinated porous pure magnesium ...

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Abstract

The invention provides a hydroxyapatite coating with biological activity and a hierarchical structure on the surface of a degradable magnesium-based endosteal implant and a preparation method. The coating comprises an inner fluorinated film and an outer hydroxyapatite conversion coating. The method comprises the following steps of: soaking magnesium and magnesium alloy in hydrofluoric acid to generate a chemical conversion film MgF2, soaking the chemical conversion film MgF2 in solution containing calcium phosphate, and generating a dicalcium phosphate dihydrate coating by a chemical deposition method; and finally, converting the dicalcium phosphate dihydrate coating into a thick hydroxyapatite coating with a micro-nano hierarchical structure and a composite surface appearance in situ under high temperature and pressure by a hydrothermal conversion method. The hydroxyapatite coating has high bonding strength with magnesium and magnesium alloy matrixes, and the corrosion resistance andbiological activity of the magnesium matrixes are obviously improved. The preparation method is simple, convenient and feasible, has low cost, and can be applied to magnesium-based endosteal implant devices with any complex shapes.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a biologically active coating and a preparation method thereof, in particular to a hydroxyapatite coating with biological activity and a hierarchical structure on the surface of a degradable magnesium-based intraosseous plant and its Preparation. Background technique [0002] Medical magnesium alloy materials and bone implant devices are known as "revolutionary metal biomaterials" because of their good biocompatibility, toughness and in vivo degradability, and they have been developed by major countries in the world in the past 10 years. field of biomaterials. This new type of medical metal material cleverly uses the characteristics of magnesium alloys that are prone to corrosion and degradation in the human environment to achieve the medical clinical purpose of metal implants gradually degrading in the body until they disappear. [0003] At present, the common bone ...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/30A61L27/32A61L27/04C23C22/34
CPCA61L27/58A61L27/306A61L27/32A61L27/047C23C22/34A61L2400/18A61L2420/02A61L2420/08A61L2430/02
Inventor 裴佳尤茗语周可袁广银
Owner SHANGHAI JIAO TONG UNIV
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