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NiPS3 nano-drug with tumor targeting, preparation method thereof and application of NiPS3 nano-drug

A nano-drug and tumor-targeting technology, which is applied in the direction of nano-drugs, anti-tumor drugs, medical preparations of non-active ingredients, etc., can solve the problems of highly stable generation of active oxygen and inability to perform photodynamic therapy, and achieve rich raw materials, Huge market value and potential value, highly controllable effect

Inactive Publication Date: 2020-12-11
SHENZHEN HANGUANG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few of these materials currently being studied can combine high stability, low toxicity, and the generation of reactive oxygen species under oxygen-independent conditions.
A major factor that has been severely restricting photodynamic therapy in the field of anti-tumor therapy is the lack of oxygen in the tumor microenvironment. It is difficult for existing photosensitizers to generate reactive oxygen species in the microenvironment of tumor hypoxia, resulting in the inability to carry out the treatment under hypoxic conditions. photodynamic therapy

Method used

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  • NiPS3 nano-drug with tumor targeting, preparation method thereof and application of NiPS3 nano-drug
  • NiPS3 nano-drug with tumor targeting, preparation method thereof and application of NiPS3 nano-drug
  • NiPS3 nano-drug with tumor targeting, preparation method thereof and application of NiPS3 nano-drug

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preparation example Construction

[0035] A second aspect, the present invention also provides a tumor targeting having NiPS 3 Methods of synthesizing nano medicament, comprising the steps of:

[0036] Providing a two-dimensional NiPS 3 Nanosheet miscible with triphenylphosphine in ethanol. After sonication, centrifugation, collecting the lower liquid, again added triphenylphosphine lower fluid in absolute ethanol, the ultrasonic produced with tumor targeting NiPS 3 Nano drugs.

[0037] Preferably, the step of preparing single targeting nanosystems, the two-dimensional NiPS 3 Semiconductor nanoparticles with triphenylphosphine in 1: 1 weight ratio dissolved in absolute ethanol, after sonication 3h 12000r / min, centrifuged 10min.

[0038] Preferably, after the addition of triphenylphosphine to the lower liquid absolute ethanol after the ultrasonic 3h, produced with tumor targeting NiPS 3 Nano drugs.

[0039] Preferably, the two-dimensional NiPS 3 Electrochemical method for preparing the release sheet using nanopart...

Embodiment 1

[0046] Having a tumor targeting NiPS 3 NiPS having tumor targeting methods of preparation and pharmaceutical preparation of nano 3 Nano-drug, comprising the steps of

[0047] (1) Preparation bulk NiPS 3 Material

[0048] Prepared by CVT chunk NiPS 3 Crystals. The stoichiometric molar ratio (1: 1: 3) of high purity nickel, phosphorous, sulfur powder (total mass ≈2g) mixed thoroughly ground in a glove box. Then, the powder is vacuum sealed in a quartz tube (vacuum quartz tube length 25 cm, an outer diameter of 13mm, a wall thickness of 1 mm) at 10 -5 Pa under vacuum, using equipment partulab oxygen / hydrogen torch.

[0049] Next, the sealed tube was placed in a double-stage furnace. Then, the reaction zone temperature is set and growth region is 700 ℃ and 650 ℃, heating rate of 1 ℃ · min -1 , And maintain the appropriate temperature for seven days, to produce a temperature gradient in the volume of the crystal growth. Finally, the dual-stage furnace cool to room temperature, the co...

Embodiment 2

[0063] The following tumor-specific targeting NiPS illustrated by Example 2 3 Preparation of nanoparticulate drug and prepared with tumor targeting NiPS 3 Nanomedicine

[0064] Example 2

[0065] NiPS having tumor targeting can be carried out under anaerobic conditions in the photodynamic treatment of tumors 3 Methods of synthesizing nano medicament, comprising the steps of:

[0066] (1) the prepared NiPS 3The semiconductor nano-sheet with triphenylphosphine according to 1: 1 weight ratio dissolved in absolute ethanol, after sonication 3h 12000r / min centrifugal 10min, supernatant was discarded portion, the lower liquid collection.

[0067] (2) Press NiPS3 to TPP mass ratio of 1: 1 provides TPP, the TPP dissolved in absolute ethanol, and sufficiently dissolved under sonication conditions.

[0068] (3) the bottom part of the liquid collected in the bottom layer was added in step (2) in absolute ethanol TPP continued to sonicate NiPS 3 -TPP targeted nanosystems (abbreviated subsequ...

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Abstract

The invention provides an NiPS3 nano-drug with tumor targeting. The NiPS3 nano-drug comprises a two-dimensional NiPS3 nano-sheets and triphenylphosphine, wherein the two-dimensional NiPS3 nano-sheetsare each coated with the triphenylphosphine. According to the NiPS3 nano-drug with tumor targeting provided by the invention, in an anaerobic pathway, holes generated by optical excitation in the two-dimensional NiPS3 nano-sheets can oxidize OH<-> in water to generate .OH, which represents the possibility of anaerobic photodynamics. Therefore, an NiPS3 semiconductor photosensitive nano-material can be applied to the anaerobic condition to generate active free radicals to further start a cell apoptosis pathway. The two-dimensional NiPS3 nanosheets have an obvious photodynamic effect, high chemical stability, low toxicity and good biocompatibility, and have a wide application prospect in the field of photothermal therapy, photodynamics therapy and drug-loaded therapy. The invention further discloses a preparation method for and application of the NiPS3 nano-drug with tumor targeting.

Description

Technical field [0001] The present invention relates to the field of bio-nanotechnology medicine, particularly relates to having a tumor targeting NiPS 3 Nano-drug, the present invention further relates to having a tumor targeting NiPS 3 Methods of synthesizing nano medicament, the present invention further relates to having a tumor targeting NiPS 3 Application of nano drugs. Background technique [0002] Dimensional material refers to a material consisting of only the electron motion (movement plane) in the two-dimensional non-nanoscale (1-100 nm). In recent years, graphene, black phosphorus (phosphorus-ene), alkenyl silicon, germanium alkenyl, antimony alkenyl, disulfides and metal (e.g., titanium disulfide, molybdenum disulfide) and a series of only a single atomic layer thickness quasi-two-dimensional material have been discovered, they (e.g. photothermal therapy, photodynamic therapy, drug therapy and photoacoustic imaging) in the biomedical field has potential applications....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/54A61K47/69A61P35/00B82Y5/00B82Y40/00C30B7/12C30B29/46C30B29/64
CPCA61K41/0057A61K47/54A61K47/6953A61P35/00B82Y5/00B82Y40/00C30B7/12C30B29/46C30B29/64
Inventor 张家宜吴宗泽
Owner SHENZHEN HANGUANG TECH CO LTD
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