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A nanocomposite material with photodynamic and photothermal combined therapy functions and its preparation method and application

A nano-composite material and combined therapy technology, applied in the field of nano-composite materials and its preparation, can solve the problems of limited penetration of photosensitizers, inability to obtain therapeutic effects, power and photothermal recurrence, etc., and achieve high photothermal conversion efficiency, Good photodynamic effect and low cost

Active Publication Date: 2021-08-03
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In photodynamic therapy, due to the limited penetration of photosensitizers and severe local hypoxia due to tissue oxygen consumption after prolonged treatment, which hinders further operations, ideal therapeutic effects cannot be achieved
However, the excessive heat energy generated by the laser absorbed by photothermal therapy may cause unnecessary heating effects on normal tissues, limiting the power of the irradiated laser and the possibility of recurrence of photothermal therapy limit the effect of photothermal therapy.

Method used

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  • A nanocomposite material with photodynamic and photothermal combined therapy functions and its preparation method and application
  • A nanocomposite material with photodynamic and photothermal combined therapy functions and its preparation method and application
  • A nanocomposite material with photodynamic and photothermal combined therapy functions and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Step 1. Synthesis of metal Ir complexes

[0051]

[0052] Ⅰ) Take 1g of benzothiophene-2-boronic acid, 0.9g of 1-chloroisoquinoline, and 0.3g of tetrakistriphenylphosphine palladium into a 250mL single-necked bottle with a stirrer, blow nitrogen, then add 60mL of toluene, 20mL of ethanol, 20mL of 2M sodium carbonate aqueous solution, reflux and stir overnight, after extraction, spin dry under reduced pressure, after column purification, the white powder is iridium complex Ir-1 compound 1

[0053] Ⅱ) Take 500mg of the product obtained in I and 340mg of iridium chloride trihydrate and add it to a 100mL single-necked bottle with a stirrer, blow nitrogen, then add 30mL of ethylene glycol ether and 10mL of water, reflux and stir for 24 hours, and dry to obtain a brick red color after suction filtration powder compound 2

[0054] Ⅲ) Take 680 mg of the product obtained in step Ⅱ, 130 mg of 3-hydroxy-2-pyridinecarboxylic acid and 300 mg of sodium carbonate in a 100 mL s...

Embodiment 2

[0068] Same as Example 1, the difference lies in Step III and Step 4 in Step 1.

[0069] In step 1, III) take 680 mg of the product obtained in step II, 130 mg of 3-hydroxy-2-pyridinecarboxylic acid and 300 mg of sodium carbonate in a 100 mL single-necked bottle with a stirrer, blow nitrogen, add 30 mL of ethylene glycol ether, and at 100 ° C, Reflux and stir for 24 hours, after extraction, spin dry, and after column purification, the red powder is the iridium complex Ir-OH compound 3 Yield: 45%.

[0070] Step 4. Synthesis of mSiO 2 / CuS / Ir NPS, mix 3 mg Ir complex, 1.5 μL 3-mercaptopropyltrimethoxysilane and 1.5 mL tetrahydrofuran, add 2.3 μL 0.1M benzoin dimethyl ether tetrahydrofuran solution, and illuminate under ultraviolet light After 60 minutes, disperse the material obtained in step 3 in 20 mL of ethanol, adjust the pH to alkaline, add the lighted solution to the above solution, and heat at 25°C overnight to obtain the target product. The UV absorption figure of th...

Embodiment 3

[0072] Same as Example 1, the difference lies in Step III and Step 4 in Step 1.

[0073] In step 1, III) take 680 mg of the product obtained in step II, 130 mg of 3-hydroxy-2-pyridinecarboxylic acid and 300 mg of sodium carbonate in a 100 mL single-necked bottle with a stirrer, blow nitrogen, add 30 mL of ethylene glycol ether, and at 110 ° C, Reflux and stir for 12 hours, after extraction, spin dry, and after column purification, the red powder is the iridium complex Ir-OH compound 3 Yield: 55%.

[0074] Step 4. Synthesis of mSiO 2 / CuS / Ir NPS, mix 3 mg Ir complex, 1.5 μL 3-mercaptopropyltrimethoxysilane and 1.5 mL tetrahydrofuran, add 2.3 μL 0.1M benzoin dimethyl ether tetrahydrofuran solution, and illuminate under ultraviolet light For 40 minutes, disperse the material obtained in step 3 in 20 mL of ethanol, adjust the pH to alkaline, add the lighted solution to the above solution, and heat at 50°C overnight to obtain the target product. The SEM image obtained from the ...

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Abstract

A nanocomposite material with photodynamic and photothermal combined therapy functions, its preparation method and application, belonging to the technical field of nanomaterial preparation and special materials. The composite nanomaterial uses mesoporous silica nanoparticles as a carrier, and simultaneously modifies the organic photosensitizer iridium complex, nano-copper sulfide photothermal reagent and bovine serum albumin. The specific synthesis steps include the synthesis of mesoporous silica, photosensitizer Synthesis, photosensitizer modification, photothermal reagent modification and bovine serum albumin modification, and finally a mesoporous silica nanomaterial with both photothermal and photodynamic functions is obtained. The nanocomposite material with photothermal and photodynamic therapy functions has high biocompatibility, a photodynamic effect of efficiently producing singlet oxygen, and a photothermal effect of absorbing near-infrared light to generate heat. The preparation process is simple, the cost is low, and the light With technical advantages such as high thermal conversion efficiency, good photodynamic effect and wide application range, it has important application prospects in tumor treatment.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation technology and special material technology, and specifically relates to a nanocomposite material with combined photodynamic and photothermal therapy functions, a preparation method and application thereof. Background technique [0002] In recent centuries, cancer has become one of the main factors threatening human life. On the one hand, due to the low specificity and sensitivity of the current conventional diagnostic methods, it is difficult to detect in the early stage of tumor development. When the diagnosis is made, the tumor cells have already metastasized, thus missing the best time for treatment, which further causes cancer to be discovered late and difficult to cure. status quo. On the other hand, the current treatment methods for cancer mainly include traditional surgical resection, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, etc., but these treatments ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/52A61K47/62A61P35/00B82Y5/00
CPCA61K41/0052A61K41/0057B82Y5/00A61K2300/00
Inventor 刘湘梅韩艺蕃蒋嘉洋邹亮田康赵强刘淑娟黄维
Owner NANJING UNIV OF POSTS & TELECOMM
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