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A kind of sericin medical dressing and production method thereof

A technology of sericin and production method, applied in medical science, resistance to vector-borne diseases, bandages, etc., can solve the problems of high price and difficult for patients to bear

Active Publication Date: 2022-05-20
HENAN MINXING COCOON SILK +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most representative one is the wound dressing with vacuum reservoir invented by D. Fink, etc., which can timely drain wound exudate and keep the wound from infection. The wound surface material has nutritional functions, and the wound heals quickly, but the price is extremely high. It is difficult for patients to bear

Method used

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  • A kind of sericin medical dressing and production method thereof
  • A kind of sericin medical dressing and production method thereof
  • A kind of sericin medical dressing and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1) Dissolve silk fibroin powder into ionized water, prepare sericin solution, and set aside;

[0051] 2) Dissolve soybean protein isolate in a phosphate solution with pH 7.4 at 40-80°C, then add vinyltrimethoxysilane and N-hydroxysuccinimide to mix, adjust the pH of the reaction system to 4-7 after stirring , stirred and reacted at 20-50°C for 30-60 minutes, then added dopamine and fluoxetine, maintained the pH value of the reaction system at 4-7, continued to stir and reacted at 20-50°C for 10-36 hours, finally dialyzed and freeze-dried to obtain Modified soybean protein isolate, spare;

[0052] 3) adding oyster shell powder to fresh aloe vera gel and stirring, adding docosahexaenoic acid, ascorbic acid, titanium dioxide, camellia oil and linoleic acid in sequence during the stirring process to obtain a mixed paste, which is set aside;

[0053] 4) Mix chitosan, xanthan gum, panax notoginseng, quercetin, D-arbutin, carbomer, urea capsule and drug extract, add appropria...

Embodiment 2

[0061] 1) Dissolve silk fibroin powder into ionized water, prepare sericin solution, and set aside;

[0062] 2) Dissolve soybean protein isolate in a phosphate solution with pH 7.4 at 40-80°C, then add vinyltrimethoxysilane and N-hydroxysuccinimide to mix, adjust the pH of the reaction system to 4-7 after stirring , stirred and reacted at 20-50°C for 30-60 minutes, then added dopamine and fluoxetine, maintained the pH value of the reaction system at 4-7, continued to stir and reacted at 20-50°C for 10-36 hours, finally dialyzed and freeze-dried to obtain Modified soybean protein isolate, spare;

[0063] 3) adding oyster shell powder to fresh aloe vera gel and stirring, adding docosahexaenoic acid, ascorbic acid, titanium dioxide, camellia oil and linoleic acid in sequence during the stirring process to obtain a mixed paste, which is set aside;

[0064] 4) Mix chitosan, xanthan gum, panax notoginseng, quercetin, D-arbutin, carbomer, urea capsule and drug extract, add appropria...

Embodiment 3

[0072] 1) Dissolve silk fibroin powder into ionized water, prepare sericin solution, and set aside;

[0073] 2) Dissolve soybean protein isolate in a phosphate solution with pH 7.4 at 40-80°C, then add vinyltrimethoxysilane and N-hydroxysuccinimide to mix, adjust the pH of the reaction system to 4-7 after stirring , stirred and reacted at 20-50°C for 30-60 minutes, then added dopamine and fluoxetine, maintained the pH value of the reaction system at 4-7, continued to stir and reacted at 20-50°C for 10-36 hours, finally dialyzed and freeze-dried to obtain Modified soybean protein isolate, spare;

[0074] 3) adding oyster shell powder to fresh aloe vera gel and stirring, adding docosahexaenoic acid, ascorbic acid, titanium dioxide, camellia oil and linoleic acid in sequence during the stirring process to obtain a mixed paste, which is set aside;

[0075] 4) Mix chitosan, xanthan gum, panax notoginseng, quercetin, D-arbutin, carbomer, urea capsule and drug extract, add appropria...

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Abstract

The invention discloses a sericin medical dressing and a production method thereof. The scheme includes the following steps: 1) dissolving silk fibroin powder into ionized water, 2) modified soybean protein isolate for standby; 3) mixing 4) Mixed solution; 5) Dissolve the modified soy protein isolate in step 2) in the phosphate buffer solution of pH=7.4, add the sericin solution into it, and add the sericin solution while stirring Add the above mixed paste, add cross-linking agent, put in the mixed liquid, put it in refrigeration and lower the temperature to 2-5°C, put in the growth factor freeze-dried powder, then mix in medical seaweed fiber, heat up to 40-55°C and stir, lower the temperature Finally, add seaweed polysaccharide, thaw after repeated freezing, and obtain a dressing. The present invention has strong biodegradability, strong antibacterial properties, whitening, and scar repair. It has no irritation to the skin and no allergic reaction. It can be stored for a long time under normal temperature and sterile conditions.

Description

technical field [0001] The invention relates to the technical field of dry preparations, in particular to a method for producing a sericin medical dressing. Background technique [0002] With the improvement of living standards, wound treatment and care have received attention. For some difficult-to-heal wounds, ordinary bandaging treatment is often difficult to heal, and special means are required. Difficult-to-heal wounds generally include chronic difficult wounds such as pressure sores, diabetic foot, arteriovenous ulcers, and malignant tumors; surgical wounds such as traffic injuries, traumatic acute wounds, burns, and plastic surgery; surgical wounds such as heart stent surgery, fat liquefaction, abscess incision and drainage, etc. Wound. Reasons for difficult wound healing include certain systemic diseases that cause damage to human immune cells; old age, infirmity, malnutrition, etc. lead to insufficient cell regeneration ability; wound infection, inflammatory respo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/40A61L15/42A61L15/44A61L15/46
CPCA61L15/28A61L15/32A61L15/44A61L15/40A61L15/425A61L15/46A61L2300/414A61L2300/30A61L2300/404Y02A50/30
Inventor 王志强郭子宽徐竞一徐斌尚蕾尚玲马驰张慧华魏会丽孙冬鑫
Owner HENAN MINXING COCOON SILK
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