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Implantable ligament substitute material based on oriented carbon nanotube fibers and preparation method of implantable ligament substitute material

A technology for orienting carbon nanotubes and carbon nanotube fibers, applied in the field of medical materials, can solve the problems of poor biointegration, difficult autologous tissue regeneration, and bone tissue wear, etc., to promote bone tissue integration, promote autologous tissue regeneration and bone tissue. Integrated, fatigue-resistant effect

Active Publication Date: 2021-02-19
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention aims to meet the mechanical requirements of the current medical implanted ligaments, and at the same time solve the problems of bone tissue wear, autologous tissue regeneration difficulties, and poor biological integration faced by the current implanted ligaments, and provides an implantable ligament based on oriented carbon nanotube fibers. Ligament substitute material and preparation method thereof

Method used

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  • Implantable ligament substitute material based on oriented carbon nanotube fibers and preparation method of implantable ligament substitute material
  • Implantable ligament substitute material based on oriented carbon nanotube fibers and preparation method of implantable ligament substitute material
  • Implantable ligament substitute material based on oriented carbon nanotube fibers and preparation method of implantable ligament substitute material

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Embodiment 1

[0028] Embodiment 1, preparation of primary helically oriented carbon nanotube fibers

[0029] (1) Preparation of primary helically oriented carbon nanotube fibers by chemical vapor deposition

[0030] With the silicon wafer as the substrate, the electron beam evaporation coating apparatus successively deposits Al with a thickness of 10nm on the silicon wafer. 2 o 3 and Fe with a thickness of 1 nm as a catalyst. Put the catalyst into a tube furnace, use ethylene, argon and hydrogen as the carbon source, carrier gas and reducing gas respectively, and control the flow rate to be 90 sccm, 400 sccm and 30 sccm respectively, at 740 o C for 10 minutes to obtain a highly oriented carbon nanotube array on the substrate. Use a blade to pull out carbon nanotube ribbons from the array, collect and fix them at the end of the spindle, and rotate at a constant speed to continuously obtain oriented helical carbon nanotube fibers ( figure 1 a, b). Control the motor speed to 1000 rpm, and...

Embodiment 2

[0034] Embodiment 2, preparation of two-stage helically oriented carbon nanotube fibers

[0035] 50 first-stage helical carbon nanotube fibers with a length of 20 cm and a diameter of 10 μm are arranged in parallel, gathered together in one place, fixed at both ends, one of which is fixed on the electric rotating machine, and the other end is kept fixed, at 1000 rpm Rotate at a constant speed of 30 seconds at a speed of 1 minute to obtain secondary fibers with a length of about 10 cm and a diameter of about 150 µm.

Embodiment 3

[0036] Embodiment 3, the preparation of tertiary double helical carbon nanotube fiber

[0037] Five secondary fibers with a length of 20 cm and a diameter of 150 µm are arranged in parallel, gathered together in one place, fixed at both ends, one end is fixed on the rotating machine, and the other end is kept fixed, and rotated at a constant speed of 1000 rpm For 30 seconds, remove both ends at the same time and keep the length unchanged, fix it on the paper, clamp the middle of the fiber with tweezers, fold the fiber, make the two fixed ends overlap, and fix them together, release the tweezers to release the stress, A tertiary double helix structure fiber can be obtained.

[0038] Tertiary fibers with a double helix structure such as image 3 Shown in electron microscope image. The nano-scale pore structure of the primary fiber is preserved in the tertiary fiber, and a large number of micron-scale pore structures between the primary fiber and the file fiber are introduced a...

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Abstract

The invention belongs to the field of medical materials, and particularly relates to an implantable ligament substitute material based on oriented carbon nanotube fibers and a preparation method of the implantable ligament substitute material. On the basis of the oriented carbon nanotube fibers, double-helix fibers are obtained through multistage helix of multiple strands of fibers and stress release and serve as the ligament implant material. The tensile modulus of the ligament material is 1.4-4 GPa, the elongation at break is 10-30%, and the ligament material can meet the mechanical requirements of implanted ligaments; and the density is 0.3-0.9 g / cm<3>, and a large number of nano-scale and micron-scale oriented pore channels similar to the structure of the autologous ligament are formed. After a New Zealand rabbit ligament defect model is implanted for 4 weeks through an anterior cruciate ligament reconstruction operation, new bones grow into gaps between ligaments and bone ducts, and 13 weeks later, the new bones are fused into the multi-stage fiber ducts, so that the implanted ligaments and bone tissues are completely integrated. The implantable ligament material can be used for alternative implantation of ligaments of animals such as mice, rabbits, cats, dogs, sheep, pigs and humans.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to an implantable ligament replacement material based on aligned carbon nanotube fibers and a preparation method thereof. Background technique [0002] Dense connective tissue is the key tissue that connects bones and bones, and between bones and muscles, and is the key to the body's exercise function. Take the anterior cruciate ligament as an example. The human body relies on tens of thousands of bendings of the anterior cruciate ligament in a day's movement. In reciprocating motion, ligaments are always in a state of stress or tension, and sports injuries are common. With the development of comprehensive fitness campaigns and the increasing emphasis on sports among the people, ligament-related sports injuries are also on the rise. After ligament rupture, reconstructive surgery is the best option. According to statistics, one out of every 1,250 people needs ACL reconst...

Claims

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Application Information

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IPC IPC(8): D02G3/16D02G3/44A61L27/08A61L27/50A61L27/56
CPCD02G3/16D02G3/448A61L27/08A61L27/50A61L27/56A61L2400/12A61L2430/10D10B2101/122
Inventor 陈培宁解松林徐一帆赵天成万方彭慧胜
Owner FUDAN UNIV
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