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Preparation method for improving dissolution rate of hypoglycemic drugs

A dissolution rate and drug technology, which is applied in the directions of drug combinations, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of low dissolution rate of hypoglycemic drugs, slow hypoglycemic efficiency of hypoglycemic drugs, and insufficient drug efficacy. , to increase the dissolution rate, reduce the adhesion, and improve the effect of mutual promotion

Inactive Publication Date: 2021-04-30
BEIJING WANHUI DOUBLE CRANE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a preparation method for improving the dissolution rate of hypoglycemic drugs, so as to solve the problem that the dissolution rate of current hypoglycemic drugs in the human body is low, and it takes a long time for the hypoglycemic drugs to make the main components of the hypoglycemic drugs in the blood Reaching a high blood concentration, the hypoglycemic drug's hypoglycemic efficiency is slow, and the drug effect is not obvious enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] A preparation method for improving the dissolution rate of hypoglycemic drugs, comprising the following steps:

[0034] S1, sending the prepared hypoglycemic drug into a low-temperature jet mill for low-temperature pulverization to obtain hypoglycemic drug powder;

[0035] S2, configuring an appropriate amount of solubilizer, sending the solubilizer and disintegrant into ultrasonic vibrating sieves, and performing vibration screening to obtain solubilizer powder and disintegrant powder respectively;

[0036] S3, after mixing the hypoglycemic drug powder, solubilizer powder and disintegrating agent powder uniformly according to a certain ratio, adding a binder to the mixture for stirring, after stirring, sending the mixture into a wet granulator for granulation to obtain mixture granules ;

[0037] S4, sending the mixture granules into a dryer for drying treatment, sending the dried mixture granules and coating agent into a multi-functional fluidized granulation coating...

Embodiment example 1

[0055] Mix glipizide, gliquidone, gliclazide, acarbose, acarbose, and pioglitazone in equal proportions to make hypoglycemic drugs, and send the prepared hypoglycemic drugs into a low-temperature jet mill , carrying out low-temperature pulverization treatment, the temperature of the low-temperature pulverization is -90°C, and the hypoglycemic drug powder is obtained, and the diameter of the hypoglycemic drug powder is 21 μm;

[0056] After mixing crospovidone, sodium carboxymethyl starch and croscarmellose sodium uniformly according to the mass ratio of 1:1:3, a disintegrant is obtained;

[0057] Weigh 38 parts of refined cotton and 42 parts of wheat straw, cut them into thin slices, and put them into a reaction kettle containing acid liquid, increase the temperature of the reaction kettle to raise the temperature in the reaction kettle to 78°C, and after 3 hours of reaction, send the reaction product into the In the mixing tank, pour pure water into the mixing tank, stir well...

comparative example 1

[0062] Mix glipizide, gliquidone, gliclazide, acarbose, acarbose, and pioglitazone in equal proportions to make hypoglycemic drugs, and put 100g of hypoglycemic drugs into 0.12mol / L hydrochloric acid solution Inside, after stirring and mixing evenly, take 10ML solution every 0.5h, measure the hypoglycemic drug content in the solution, and end after taking 5 times.

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Abstract

The invention relates to the technical field of hypoglycemic drugs, in particular to a preparation method for improving the dissolution rate of hypoglycemic drugs, which comprises the following steps: S1, sending the prepared hypoglycemic drugs into a low-temperature jet mill, and carrying out low-temperature crushing treatment to obtain hypoglycemic drug powder; S2, preparing a proper amount of solubilizing agent, respectively feeding the solubilizing agent and the disintegrating agent into an ultrasonic vibrating screen, and carrying out vibrating screening treatment to respectively obtain solubilizing agent powder and disintegrating agent powder; and S3, uniformly mixing the hypoglycemic drug powder, the solubilizer powder and the disintegrating agent powder according to a certain ratio, and then adding the adhesive into the mixture for stirring, so as to effectively solve the problems that the existing hypoglycemic drugs is relatively low in dissolution rate in a human body; the problems that the main components of the hypoglycemic drugs in blood can reach higher blood concentration after a long time, the hypoglycemic efficiency of the hypoglycemic drug is lower, and the drug effect is not obvious enough are solved.

Description

technical field [0001] The invention relates to the technical field of hypoglycemic drugs, in particular to a preparation method for improving the dissolution rate of hypoglycemic drugs. Background technique [0002] Diabetes mellitus is a chronic comprehensive disease mainly caused by the disorder of glucose metabolism caused by the absolute or relative deficiency of insulin, or the decreased sensitivity of target cells to insulin. The occurrence of type 2 diabetes is the combined effect of peripheral insulin resistance and β-cell dysfunction. As a result, when the blood sugar control of diabetic patients still cannot reach the treatment target after diet and exercise therapy and diabetes health care education, drug treatment is required. Antidiabetic chemical drugs can be roughly divided into oral hypoglycemic drugs and injection hypoglycemic drugs. Oral hypoglycemic drugs commonly used in China are divided into insulin secretagogues, metformin, α-glucosidase inhibitors, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/4439A61K31/64A61K31/7036A61K47/10A61K47/32A61K47/36A61K47/38A61K47/40A61K47/08A61P3/10C08B15/02
CPCA61K9/5036A61K9/5015A61K31/64A61K31/7036A61K31/4439A61K47/38A61K47/36A61K47/32A61K47/10A61P3/10C08B15/02
Inventor 曲民春陈利敏王义波艾俊丽田麒宋芙钟皓白艳娇孟晓雪王瑾孙国栋
Owner BEIJING WANHUI DOUBLE CRANE PHARMA
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