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Bone repair scaffold with microelement-loaded coating and preparation method of bone repair scaffold

A trace element, bone repair technology, applied in the field of medical materials, can solve the problems of low strength and poor toughness, and achieve the effect of promoting repair ability, improving strength and toughness, and promoting bone repair

Inactive Publication Date: 2021-05-11
JIHUA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bioceramic porous bone repair scaffolds have the problems of low strength and poor toughness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] This embodiment is used to illustrate a method for preparing a bone repair scaffold with a single trace element (Mg)-loaded coating according to the present invention, which specifically includes the following steps:

[0040] (1) Take by weighing 2.25g gelatin particles, 27.75g deionized water, and prepare a gelatin aqueous solution with a mass concentration of 7.5%, add magnesium sulfate heptahydrate to it, and prepare a gelatin solution with a magnesium ion concentration of 5mmol / L. Immerse the sintered bioceramic stent in the solution, infiltrate it in a vacuum drying oven at a temperature of 60°C and a pressure of -0.08MPa for 10 minutes, then take out the sample and dry it in a drying oven at a temperature of 50°C for 12 hours;

[0041] (2) Using absolute ethanol as a solvent, prepare a 20 mg / mL genipin solution. The dried samples were immersed in the solution for 12 h at room temperature to cross-link the gelatin. After cross-linking, the samples were taken out, ...

Embodiment 2

[0043] This embodiment is used to illustrate a method for preparing a bone repair scaffold with two kinds of trace element (magnesium, zinc) loaded coatings according to the present invention, which specifically includes the following steps:

[0044] (1) Weigh 7.5g of gelatin particles, 92.5g of deionized water, prepare an aqueous gelatin solution with a mass concentration of 7.5%, add zinc sulfate thereto, and prepare gelatin solution A with a zinc ion concentration of 10 μmol / L;

[0045] Immerse the sintered bioceramic scaffold in gelatin solution A, infiltrate it in a vacuum drying oven at a temperature of 60°C and a pressure of -0.08MPa for 10 minutes, then take out the sample and dry it in a drying oven at a temperature of 50°C for 12 hours;

[0046](2) Weigh 7.5g of gelatin granules, 92.5g of deionized water, prepare a gelatin aqueous solution with a mass concentration of 7.5%, add magnesium sulfate heptahydrate to it, and prepare gelatin solution B with a magnesium ion c...

Embodiment 3

[0050] This example is used to illustrate a method for preparing a bone repair scaffold with three trace elements (magnesium, copper, strontium) loaded coatings according to the present invention, which specifically includes the following steps:

[0051] (1) Weigh 7.5g of gelatin particles, 92.5g of deionized water, prepare an aqueous gelatin solution with a mass concentration of 7.5%, add strontium chloride hexahydrate to it, and prepare gelatin solution A with a strontium ion concentration of 0.1mmol / L;

[0052] Immerse the sintered bioceramic scaffold in gelatin solution A, infiltrate it in a vacuum drying oven at a temperature of 60°C and a pressure of -0.08MPa for 10 minutes, then take out the sample and dry it in a drying oven at a temperature of 50°C for 12 hours;

[0053] (2) Take by weighing 7.5g gelatin granules, 92.5g deionized water, prepare the gelatin aqueous solution that mass concentration is 7.5%, add magnesium sulfate heptahydrate and copper sulfate pentahydra...

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PUM

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Abstract

The invention relates to the technical field of medical materials, and particularly discloses a bone repair scaffold with a microelement-loaded coating and a preparation method of the bone repair scaffold. The bone repair scaffold comprises a porous ceramic scaffold body and a gelatin coating on the surface of the porous ceramic scaffold body; the gelatin coating contains microelements, wherein the microelements are selected from one or more of magnesium, copper, calcium, zinc, strontium and silicon. According to the bone repair scaffold, the microelement gelatin coating is loaded on the basis of the porous ceramic scaffold, so that the strength and toughness of the porous ceramic bone repair scaffold are improved, and the degradation rate of gelatin can be controlled by controlling the crosslinking degree of the gelatin and a crosslinking agent, and then, the release rate of the microelements is further controlled, which is conducive to osteogenesis and angiogenesis so that bone repair is further promoted. Furthermore, the different microelements are distributed at different positions of the gelatin coating, so that the microelements are released in sequence at different time, and the repair capability of bone repair at each time stage is promoted in a more targeting manner.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a bone repair bracket with a trace element loading coating. Background technique [0002] The problem of bone defect repair has always been a clinical problem to be solved urgently. The emergence of bioactive ceramics provides a new solution for bone defect repair. Bioactive ceramics have good biocompatibility and osteoconductivity, and can effectively promote the formation of new bone in bone defects. However, bioceramic porous bone repair scaffolds have the problems of low strength and poor toughness. [0003] Gelatin is the product of thermal deformation or partial hydrolysis of collagen, which has good biocompatibility and biodegradability. The preparation of gelatin-coated porous ceramic bone repair scaffolds by vacuum impregnation technology can improve the strength and toughness of porous bone repair scaffolds. [0004] If the gelatin coating can be loaded wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/34A61L27/10A61L27/54A61L27/58
CPCA61L27/56A61L27/10A61L27/34A61L27/54A61L27/58A61L2430/02A61L2300/412
Inventor 刘亚雄李腾飞伍言龙康建峰易荣李涤尘王玲连芩高琳
Owner JIHUA LAB
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