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Visual fluorescent fiber as well as preparation method and application thereof

A fluorescent fiber and fiber technology, which is applied in the fields of material synthesis chemistry and clinical medicine, can solve problems such as the lack of methods for threading tubes and the difficulty of fast and accurate threading

Active Publication Date: 2021-05-18
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The key step in the 360° viscous canalectomy is to pass through the Schlemm's canal around the circumference (pipe-through), but it is difficult to quickly and accurately pass through the Schlemm's diameter of only about 300 μm with the microcatheter and suture-piercing methods currently used clinically. lumen around the tube
Although many scholars at home and abroad have conducted a lot of research to try to solve the problem of passing through the 360°Schlemm pipe, there is still a lack of a fast, accurate, stable and safe method for passing through the pipe.

Method used

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  • Visual fluorescent fiber as well as preparation method and application thereof
  • Visual fluorescent fiber as well as preparation method and application thereof
  • Visual fluorescent fiber as well as preparation method and application thereof

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preparation example Construction

[0037] Another aspect of the embodiments of the present invention also provides a method for preparing the above-mentioned visible fluorescent fiber, including:

[0038] The core layer fiber doped with fluorescent material is prepared, and the shell layer is coated on the surface of the core layer fiber.

[0039] In some preferred embodiments, the preparation method of the visible fluorescent fiber includes: injecting the cellulose solution doped with the fluorescent material into a coagulation bath containing a dehydrating solvent and a cationic surfactant, undergoing wet stretching and drying to obtain core layer fibers, the cellulose solution contains 1-10wt% cellulose material and 0.01-2wt% fluorescent material.

[0040] Alternatively, a calcium alginate solution doped with a fluorescent material at a concentration of 1-10% is injected into a coagulation bath containing metal cations and cationic surfactants, subjected to wet stretching and dried to obtain core layer fiber...

Embodiment 1

[0052] Example 1: Blend 10 mg CTAB-InP@ZnS quantum dots (or 10 mg Nile Red), 10 g sodium alginate, and 490 g deionized water, stir vigorously at 60°C for 3 hours, vacuum pump to remove air bubbles, and remove the pre-liquid Put it into a plastic syringe, and inject it into the coagulation bath through a steel pipe with an inner diameter of 0.41mm and a length of 15cm at a speed of 5ml / min. The composition of the coagulation bath is 0.1mol / L CaCl 2 and 0.1mmol / L CTAB, after soaking in the coagulation bath for 10min, the fibers were washed in deionized water to remove Ca on the surface 2+ and CTAB, then the fibers were naturally air-dried in an air with a humidity of 50%, and the resulting fibers were observed by an environmental scanning electron microscope, and the entire fiber diameter was 150±10 μm; the 10cm core layer fiber was placed in 50ml of ethanol, 1ml of ethyl orthosilicate ester, 10ml of 28% ammonia water mixed solution, heated at 60°C, stirred vigorously for 6 hour...

Embodiment 2

[0053] Example 2: Blend 10 mg CTAB-InP@ZnS quantum dots (or 10 mg Nile Red), 20 g cellulose nanofibers, and 480 g deionized water, stir vigorously for 3 hours, remove air bubbles by vacuum pumping, and put the pre-liquid into a plastic syringe , at a speed of 5ml / min, through a steel pipe with an inner diameter of 0.41mm and a length of 15cm, inject it into the coagulation bath. The coagulation bath consists of acetone and 0.1mmol / LCTAB. Fix it to make it dry naturally in the air with a humidity of 50%. The obtained fiber is observed by an environmental scanning electron microscope. The monofilaments inside the macroscopic fiber are closely arranged, the orientation is high, the surface is smooth, and the diameter of the entire fiber is 150 ± 10 μm; Dissolve 0.1 g of fluorinated silicon dioxide particles in 10 ml of tetrahydrofuran, ultrasonically treat for 30 min, then place a 10 cm core layer fiber in tetrahydrofuran dissolved in fluorinated silicon dioxide nanoparticles, sti...

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Abstract

The invention discloses a visual fluorescent fiber as well as a preparation method and application thereof. The visual fluorescent fiber comprises a core layer fiber doped with a fluorescent material and a shell layer coating the core layer fiber, and at least the surface of the outermost shell layer is hydrophobic. The visual fluorescent fiber provided by the invention has the advantages of high brightness, good hydrophobicity, high stability, mechanical property, controllable diameter and the like, the preparation process is simple, the reaction condition is mild, large-scale production can be realized, the fluorescent fiber is expected to provide a simpler, more accurate, quicker and safer tube penetrating method for 360-degree viscous tubule operation, the operation success rate is increased, the method has an extremely high clinical application prospect, and meanwhile, a new research thought is provided for 360-degree viscocanlostomy and glaucoma treatment.

Description

technical field [0001] The invention belongs to the technical fields of material synthesis chemistry and clinical medicine, and in particular relates to a visible fluorescent fiber and its preparation method and application. Background technique [0002] Glaucoma is the world's first irreversible blinding eye disease. The pathological mechanism is that the resistance of the inner wall of Schlemm's canal and adjacent canal tissue increases, the outflow of aqueous humor in the eye is blocked, and the intraocular pressure increases. The purpose of treatment is to reduce intraocular pressure, and ultimately protect the optic nerve from damage and maintain the existing visual function. It is divided into three methods: medicine, laser and surgery. Surgery is the most effective treatment method, and the most cutting-edge and most effective is 360 °Viscoelastic Schlemm tube (viscosal canal) surgery can effectively promote the drainage of aqueous humor and reduce intraocular pressur...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/08A61L31/04A61F9/007
CPCA61L31/14A61L31/042A61L31/088A61F9/00781A61F2009/00891A61L2400/12C08L1/00C08L5/04
Inventor 王强斌孙自强
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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