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Preparation method of polytetrafluoroethylene boron affinity blotting membrane and application of polytetrafluoroethylene boron affinity blotting membrane in selective separation of shikimic acid

A technology of polytetrafluoroethylene and imprinted membrane, which is applied in chemical instruments and methods, separation/purification of carboxylic acid compounds, selective adsorption, etc., can solve problems such as difficulty in separation and recovery, achieve good application prospects, effectively separate, and improve adsorption efficiency effect

Pending Publication Date: 2021-06-25
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, most of the materials currently used to separate shikimic acid are powders, which are difficult to separate and recover

Method used

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  • Preparation method of polytetrafluoroethylene boron affinity blotting membrane and application of polytetrafluoroethylene boron affinity blotting membrane in selective separation of shikimic acid
  • Preparation method of polytetrafluoroethylene boron affinity blotting membrane and application of polytetrafluoroethylene boron affinity blotting membrane in selective separation of shikimic acid
  • Preparation method of polytetrafluoroethylene boron affinity blotting membrane and application of polytetrafluoroethylene boron affinity blotting membrane in selective separation of shikimic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A method for preparing a polytetrafluoroethylene boron affinity imprinted membrane, comprising the steps of:

[0034] a) Dissolve 0.1g of dopamine hydrochloride in 0.1211g of Tris aqueous solution per 100mL, after fully stirring, adjust the pH of the solution to 8.5 with hydrochloric acid, and immerse a piece of commercially available polytetrafluoroethylene (PVDF) film (diameter 25mm, pore size 0.8μm) In the above solution, after stirring for 3 hours, take it out, wash the membrane material with distilled water five times, and dry it at 50°C to obtain the PVDF@PDA membrane material;

[0035] b) Dissolve 0.5mL KH570 in 70mL of absolute ethanol, add a piece of PVDF@PDA film after ultrasonic dispersion for 0.5h, under magnetic stirring, reflux at 40°C for 12h, take it out, wash it with distilled water, and dry it in vacuum at 30°C to obtain vinyl Modified PVDF membrane material;

[0036] c) Dissolve a piece of vinyl-modified PVDF membrane material in 25mL of acetonitrile...

Embodiment 2

[0040] A method for preparing a polytetrafluoroethylene boron affinity imprinted membrane, comprising the steps of:

[0041]a) Dissolve 0.5g of dopamine hydrochloride in 0.1211g of Tris aqueous solution per 100mL, after fully stirring, adjust the pH of the solution to 8.5 with hydrochloric acid, and immerse a piece of commercially available polytetrafluoroethylene (PVDF) film (diameter 25mm, pore size 0.8μm) In the above solution, after stirring for 9 hours, take it out, wash the membrane material with distilled water five times, and dry it at 50°C to obtain the PVDF@PDA membrane material;

[0042] b) Dissolve 1mL of KH570 in 70mL of absolute ethanol, ultrasonically disperse for 0.5h, add a piece of PVDF@PDA film, under magnetic stirring, reflux at 80°C for 24h, take it out, wash it with distilled water, and dry it in vacuum at 30°C to obtain a vinyl modified film. Permanent PVDF membrane material;

[0043] c) Dissolve a piece of vinyl-modified PVDF membrane material in 25mL ...

Embodiment 3

[0047] A method for preparing a polytetrafluoroethylene boron affinity imprinted membrane, comprising the steps of:

[0048] a) Dissolve 0.2g of dopamine hydrochloride in 0.1211g of Tris aqueous solution per 100mL, after fully stirring, adjust the pH of the solution to 8.5 with hydrochloric acid, and immerse a piece of commercially available polytetrafluoroethylene (PVDF) film (diameter 25mm, pore size 0.8μm) In the above solution, after stirring for 12 hours, take it out, wash the membrane material with distilled water five times, and dry it at 50°C to obtain the PVDF@PDA membrane material;

[0049] b) Dissolve 2mL of KH570 in 70mL of absolute ethanol, add a piece of PVDF@PDA film after ultrasonic dispersion for 0.5h, under magnetic stirring, reflux at 60°C for 24h, take it out, wash it with distilled water, and dry it in vacuum at 30°C to obtain a vinyl modified film. Permanent PVDF membrane material;

[0050] c) Dissolve a piece of vinyl-modified PVDF membrane material in ...

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Abstract

The invention belongs to the technical field of resource utilization and chemical separation, and relates to a preparation method of a polytetrafluoroethylene boron affinity blotting membrane, which comprises the steps of: dissolving dopamine hydrochloride in a Tris aqueous solution, fully conducting stirring, adjusting the pH value to 8.5, conducting immersing in a PVDF membrane, conducting stirring, conducting washing, and conducting drying at a temperature of 50 DEG C to obtain a PVDF-coated PDA membrane; dissolving KH570 in absolute ethyl alcohol, adding the PVDF-coated PDA membrane, performing heating reflux, and performing vacuum drying to obtain a vinyl modified PVDF membrane; and dissolving the vinyl modified PVDF membrane in 25 mL of acetonitrile solution, adding shikimic acid, VPBA, EGDMA and AIBN, conducting reacting in nitrogen at 40 DEG C for 2-8 h, conducting reacting at 60 DEG C for 8-16 h, conducting aging at 50-100 DEG C for 2-6 h, conducting cooling, washing and drying, conducting eluting, and conducting water washing to be neutral to obtain the product. According to the invention, PVDF is taken as a substrate, a molecularly imprinted polymer is prepared on the surface of PVDF, and a dual recognition mechanism is introduced, so that shikimic acid with a cis-dihydroxyl structure is enriched on the surface of the membrane, and effective separation of shikimic acid is realized. The method has a good application prospect in the field of enrichment, separation and purification of natural products with cis-dihydroxyl structures.

Description

technical field [0001] The invention belongs to the technical field of resource utilization and chemical separation, and relates to the preparation of a polytetrafluoroethylene membrane base material, in particular to a preparation method of a polytetrafluoroethylene boron affinity imprinted membrane and its application to selective separation of shikimic acid. Background technique [0002] Shikimic acid, also known as 3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid, is widely distributed in plant tissues in the natural environment. Shikimic acid has great application value and has anti-tumor, anti-thrombosis, cerebral ischemia and anti-inflammation effects. It is an important raw material for drug synthesis, for example, it is an essential raw material for the synthesis of the patented anti-avian influenza drug GS4104 (Tamiflu). In addition, it is also an important chemical intermediate. The current methods of obtaining shikimic acid can be divided into three categories: ...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30B01J20/28B01D15/08C08J7/12C08J7/16C08J9/26C07C51/47C07C62/32C08L27/18
CPCB01J20/268B01J20/28033B01J20/28011B01D15/08C08J7/12C08J7/16C08J9/26C07C51/47C08J2327/18C08J2201/0422C07C2601/16C07C62/32
Inventor 朱瑶邱凤仙潘志远杨冬亚张涛潘建明
Owner JIANGSU UNIV
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