Hedgehog-shaped magnetic microsphere and preparation method thereof

A technology of magnetic microspheres and hedgehogs, applied in the direction of microsphere preparation, magnetic objects, magnetic materials, etc., can solve the problems of complex preparation and simple structure, and achieve the effects of strong adhesion, strong practicability, and best application value

Active Publication Date: 2021-07-02
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the disadvantages of simple surface structure and complicated preparation of traditional magnetic microspheres, the present invention provides a hedgehog-shaped magnetic microsphere and its preparation method

Method used

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  • Hedgehog-shaped magnetic microsphere and preparation method thereof
  • Hedgehog-shaped magnetic microsphere and preparation method thereof
  • Hedgehog-shaped magnetic microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of magnetic nanoparticles:

[0032] Take 16ml of ethylene glycol solution, add 0.26g of anhydrous ferric chloride, 1.2g of sodium acetate, 0.4g of poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (molar ratio 1:1), 0.004g L-ascorbic acid and 40ul ultrapure water, stir vigorously to form a brown mixed solution. Add 0.24 g of sodium hydroxide to the mixed solution, and continue stirring for 30 min to obtain a brown transparent solution. Transfer it to a 20ml reaction kettle, and calcinate it at 190°C for 9 hours by hydrothermal method to obtain magnetic nanoparticles. The product is mixed with ethanol and water at a ratio of 1:1 and washed three times, and then washed three times with ultrapure water.

[0033] (2) Preparation of magnetic nanoparticles wrapped in silica:

[0034] Take 6ml of the above-mentioned magnetic nanoparticles and disperse them in 40ml of ethanol, add 2ml of ammonia water, ultrasonically disperse for 15min, slowly add tetrae...

Embodiment 2

[0038] (1) Preparation of magnetic nanoparticles:

[0039] Take 16ml of ethylene glycol solution, add 0.26g of anhydrous ferric chloride, 1.2g of sodium acetate, 0.4g of poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (molar ratio 1:1), 0.004g L-ascorbic acid and 100ul ultrapure water, stir vigorously to form a brown mixed solution. Add 0.24 g of sodium hydroxide to the mixed solution, and continue stirring for 30 min to obtain a brown transparent solution. Transfer it to a 20ml reaction kettle, and calcinate it at 190°C for 9 hours by hydrothermal method to obtain magnetic nanoparticles. The product is mixed with ethanol and water at a ratio of 1:1 and washed three times, and then washed three times with ultrapure water.

[0040] (2) Preparation of magnetic nanoparticles wrapped in silica:

[0041] Take 6ml of the above-mentioned magnetic nanoparticles and disperse them in 40ml of ethanol, add 2ml of ammonia water, ultrasonically disperse for 15min, slowly add tetra...

Embodiment 3

[0045] (1) Preparation of magnetic nanoparticles:

[0046] Take 16ml of ethylene glycol solution, add 0.26g of anhydrous ferric chloride, 1.2g of sodium acetate, 0.4g of poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (molar ratio 1:1), 0.004g L-ascorbic acid and 40ul ultrapure water, stir vigorously to form a brown mixed solution. Add 0.24 g of sodium hydroxide to the mixed solution, and continue stirring for 30 min to obtain a brown transparent solution. Transfer it to a 20ml reaction kettle, and calcinate it at 190°C for 9 hours by hydrothermal method to obtain magnetic nanoparticles. The product is mixed with ethanol and water at a ratio of 1:1 and washed three times, and then washed three times with ultrapure water.

[0047] (2) Preparation of magnetic nanoparticles wrapped in silica:

[0048] Take 6ml of the above-mentioned magnetic nanoparticles and disperse them in 40ml of ethanol, add 2ml of ammonia water, ultrasonically disperse for 15 minutes, slowly add 2...

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Abstract

The invention discloses a preparation method of a hedgehog-shaped magnetic microsphere. The method is based on magnetic nano particles wrapped by silicon dioxide, a silicon dioxide layer is used as a template, the silicon dioxide layer is completely etched by a one-step hydrothermal method to generate a hedgehog-shaped shell structure, and after reaction, deionized water cleaning and magnet collection are performed to obtain the hedgehog-shaped magnetic microsphere. The microsphere is characterized in that the microsphere comprises an inner core and a magnesium silicate shell, and the magnesium silicate shell is of a nano needle-shaped structure, looks like a hedgehog and has a powerful surface function; and the inner core is magnetic ferroferric oxide nano particles, and the microsphere is endowed with rapid magnetic responsiveness, so that controllable movement of the hedgehog-shaped magnetic microsphere can be realized under the action of an external magnetic field. The preparation method of the hedgehog-shaped magnetic microspheres based on the magnetic nano particles has the advantages of low cost, easiness in operation, convenience, reliability and the like.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a hedgehog-shaped magnetic microsphere and a preparation method thereof. Background technique [0002] Magnetic nanomaterials have attracted extensive attention due to their superparamagnetism, good dispersion and biocompatibility, and have excellent application prospects in the field of biotechnology, including magnetically targeted drug delivery, medical imaging, cancer diagnosis, sewage treatment, cell Separation etc. Among them, the unique magnetic response performance of magnetic microspheres makes magnetic separation technology a core technology in the field of separation analysis. Magnetic beads will not undergo magnetic aggregation without an external magnetic field. When an external magnetic field appears, these magnetic beads can quickly respond to achieve separation. target enrichment. Magnetic microsphere enrichment and separation of biomolecules has the advantag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F41/02H01F1/00H01F1/03B01J13/02
CPCH01F41/02B01J13/02H01F1/0018H01F1/0313H01F1/0311
Inventor 赵远锦杨文君商珞然王月桐余筠如张大淦
Owner NANJING DRUM TOWER HOSPITAL
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