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Preparation method of mesoporous silica nanoparticle transdermal delivery eutectic system

A technology of mesoporous silica and nanoparticles, which is applied in the field of medicine, can solve the problems of little understanding of the interaction of nanoparticles, etc., and achieve the effects of improving patient compliance, improving drug bioavailability, and increasing dispersibility

Pending Publication Date: 2021-07-23
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

(2) However, until now, little is known about how nanoparticles pass through the body's barriers and how cells absorb particles and their interactions with biological processes

Method used

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  • Preparation method of mesoporous silica nanoparticle transdermal delivery eutectic system
  • Preparation method of mesoporous silica nanoparticle transdermal delivery eutectic system
  • Preparation method of mesoporous silica nanoparticle transdermal delivery eutectic system

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Embodiment 1

[0027] Hansen solubility parameter is a method to evaluate the skin penetration ability of substances. Hansen solubility parameter (HSP) is the ability to evaluate the intermolecular dispersion force δD, polar force δP and hydrogen bond interaction force δH. It is generally believed that a substance The closer the solubility parameter of DES is to the solubility parameter of skin, the better the skin penetration ability will be, so this index can be used to screen out DES with better effect.

[0028] Hansen Solubility Parameters (HSP) were analyzed by computer, and the materials studio software was used to draw the 3D molecular structures of the prepared 20 kinds of amino acid-citric acid eutectic systems, such as figure 1 As shown; and establish a simulation box to calculate the potential distribution through the Dmol3 module, select the force field as Universal, set the initial density as 1, and use the Forcite module to perform geometric optimization and dynamic calculation ...

Embodiment 2

[0030] A method for preparing a mesoporous silica-citric acid-amino acid eutectic system. In this embodiment, lysine is selected to prepare a eutectic system. The specific process is as follows:

[0031] (1) Dissolve 16g of trimethylhexadecylammonium chloride (CTAC) in 100mL of deionized water, heat to 95°C, stir to dissolve, then add 0.5mL of triethanolamine (TEA), continue to stir for 1 hour, then gradually Add 12 mL tetraethyl orthosilicate (TEOS) dropwise, continue to react for 1 hour until a white suspension is produced, and centrifuge at 13500 rpm to obtain precipitates that are silica nanoparticles;

[0032] (2) The precipitate in step (1) was refluxed in the mixed solution of hydrochloric acid / methanol (1:4 volume ratio) for 6 hours, then centrifuged to obtain the precipitate, and the above reflux operation was repeated three times to remove the template agent CTAC, and finally obtained The precipitate was washed three times with ethanol and deionized water, centrifuge...

Embodiment 3

[0043] Prepare MSNs-CA-Lys loaded with fluorescein isothiocyanate, and investigate the transdermal ability of MSN-CA-Lys. The specific steps are as follows:

[0044] (1) Dissolve 16g of trimethylcetylammonium chloride (CTAC) in 100mL of deionized water, heat to 95°C, stir to dissolve, add 10mg of FITC fluorescent dye dissolved in 3mL of ethanol solution, and then add 0.5mL of three Ethanolamine (TEA), continued to stir for 1 hour, then added 12 mL of tetraethyl orthosilicate (TEOS) dropwise, and continued to react for 1 hour until a white suspension was produced, which was centrifuged at 13,500 rpm to obtain precipitates that were silica nanoparticles;

[0045] (2) The precipitate in step (1) was refluxed in the mixed solution of hydrochloric acid / methanol (1:4 volume ratio) for 6 hours, then centrifuged to obtain the precipitate, and the above reflux operation was repeated three times to remove the template agent CTAC, and finally obtained The precipitate was washed three tim...

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Abstract

The invention discloses a preparation method of a mesoporous silica nanoparticle transdermal delivery eutectic system. The preparation method comprises the following steps: preparing mesoporous silica nanoparticles by a template method, then covalently grafting citric acid to mesoporous silica, and finally preparing a mesoporous silica-citric acid-amino acid eutectic system by heating and vacuum evaporation. According to the invention, the mesoporous silica nanoparticles are connected with citric acid-amino acid to form a eutectic system, so that the dispersibility of the mesoporous silica is improved, a new pharmaceutical strategy is provided for transdermal delivery of the nanoparticles into a whole body circulatory system, and potential application prospects are realized in the aspects of long-acting circulating nano-drug preparation and percutaneous immunotherapy.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a method for preparing a eutectic system for transdermal delivery of mesoporous silicon dioxide nanoparticles. Background technique [0002] Many commercially available products, including food, pharmaceuticals, cosmetics and textiles, already contain nanoparticles as active agents, carriers or additives. Nanoparticles are currently being explored in several fields including materials science as well as biomedical research. (1) In dermatology and cosmetology, nanoparticles are expected to be important tools for more effective and selective targeting of drugs to skin regions and target cell populations. (2) However, until now, little is known about the mechanism by which nanoparticles pass through barriers in the human body and the mechanism of cellular uptake of particles and their interaction with biological processes. [0003] Transdermal drug delivery system (TDDS) refers to the way of...

Claims

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Application Information

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IPC IPC(8): C01B33/18A61K47/69A61K9/00B82Y5/00
CPCC01B33/18A61K47/6949A61K9/0014B82Y5/00C01P2004/04C01P2002/82C01P2002/80C01P2004/64Y02A50/30
Inventor 王承潇赵志远李明键曹玉标王丽云
Owner KUNMING UNIV OF SCI & TECH
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