Preparation method of mesoporous silica nanoparticle transdermal delivery eutectic system

Abstract

The invention discloses a preparation method of a mesoporous silica nanoparticle transdermal delivery eutectic system. The preparation method comprises the following steps: preparing mesoporous silica nanoparticles by a template method, then covalently grafting citric acid to mesoporous silica, and finally preparing a mesoporous silica-citric acid-amino acid eutectic system by heating and vacuum evaporation. According to the invention, the mesoporous silica nanoparticles are connected with citric acid-amino acid to form a eutectic system, so that the dispersibility of the mesoporous silica is improved, a new pharmaceutical strategy is provided for transdermal delivery of the nanoparticles into a whole body circulatory system, and potential application prospects are realized in the aspects of long-acting circulating nano-drug preparation and percutaneous immunotherapy.

Description

technical field

[0001] The invention belongs to the field of medicine, and relates to a method for preparing a eutectic system for transdermal delivery of mesoporous silicon dioxide nanoparticles. Background technique

[0002] Many commercially available products, including food, pharmaceuticals, cosmetics and textiles, already contain nanoparticles as active agents, carriers or additives. Nanoparticles are currently being explored in several fields including materials science as well as biomedical research. (1) In dermatology and cosmetology, nanoparticles are expected to be important tools for more effective and selective targeting of drugs to skin regions and target cell populations. (2) However, until now, little is known about the mechanism by which nanoparticles pass through barriers in the human body and the mechanism of cellular uptake of particles and their interaction with biological processes.

[0003] Transdermal drug delivery system (TDDS) refers to the way of...

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