Externally applied medicine for improving blood supply of skin flaps and preparation method of externally applied medicine

Abstract

The invention relates to an externally applied medicine for improving blood supply of skin flaps and a preparation method of the externally applied medicine. The externally applied medicine is prepared from 1000-5000 IU / mL of basic fibroblast growth factors, 10-50 mg / mL of minoxidil and 100-300 mg / mL of urea. The external applied medicine is safe, convenient, efficient and rapid and is used for preventing and treating skin expansion related complications and improving blood supply of expanded skin flaps. When a patient has poor dilation early warning signs such as capillary hyperplasia, skin thinning, transparency and the like in dilated skin tissue, the external applied medicine is applied to the surface of the dilated skin locally, so that the bad state of the skin during dilation can be improved, the regeneration of the dilated skin can be promoted, and the related complications of the dilated skin can be effectively prevented and treated.

Description

technical field [0001] The invention relates to the field of surgery-plastic repair and reconstruction of skin and soft tissue tissues, in particular, it refers to the development of new drugs applied to the treatment of skin and soft tissue expanders to improve the expansion efficiency and reduce expansion-related complications. Background technique [0002] Skin tissue defect is a common problem in plastic and reconstructive surgery. Soft tissue expansion technology is an ideal repair method because it can provide skin tissue with similar skin color and texture. However, the complication rate of soft tissue expansion can reach 17.44%, which is directly related to the limited regenerative ability of skin tissue. In clinical practice, capillary hyperplasia, skin thinning, and translucence in dilated skin tissue are early warning signs of poor dilatation, and the progression of these signs can lead to serious complications such as skin ulcers and even necrosis. When relevant...

AI Technical Summary

Problems solved by technology

[0004] Botulinum toxin type A injection: intramuscular injection is required, which is more painful and poorly accepted by patients; it will cause trauma to the expanded area and increase the risk of complications related to the expanded skin; and the treatment effect is uncertain

[0005] Coating with gelatin sponge: For certain parts such as the head and face, or larger dilators, it is difficult to cover with gelatin sponge, and there are limitations in its use

[0006] CGF injection: Blood collection is required, and the blood quality of some patients is not up to standard; it will cause damage to the expanded area and increase the risk of complications related to the expanded skin

[0007] Stem cell injection: Stem cells need to be obtained through invasive operations or surgery, and the preparation process is time-consuming and laborious; the ethical aspects are not yet clear; trauma to the expanded area increases the risk of complications related to the expanded skin

[0008] Autologous fat transplantation: fat needs to be obtained through liposuction, and many patients have less subcutaneous fat, which cannot meet the needs of transplantation

[0009] Apply drugs on the surface of the expanded skin, such as triamcinolone, sucralfate, papaverine, etc.: the side effects of the drug itself, the clinical application is limited

Images