Hydrophobic polymer hemostatic repair material and preparation method and application thereof
A technology of hydrophobic polymers and repair materials, which can be used in applications, pharmaceutical formulations, bandages, etc., can solve problems such as interface bonding failure, and achieve strong adhesion, good application prospects, and good tissue adhesion.
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Embodiment 1
[0054] A composition and preparation method of a hydrophobic polymer hemostatic repair material that can quickly adhere to a wet tissue interface, comprising the following steps:
[0055] (1) Select polyurethane as forming agent, which includes coupling unit aliphatic diisocyanate (such as 1,6-hexamethylene diisocyanate) and polymer polyol (such as polycarbonate diol) and catalytic unit dimethylaminoethoxy Ethanol or trimethylhydroxypropyl ethylenediamine (small molecule catalyst), silicone liquid (viscosity: 200mm 2 / s~500000mm 2 / s) As a flowable hydrophobic macromolecule, hydroxymethyltriethoxysilane is prepared as a tissue crosslinking agent, wherein the polyurethane content is 40 to 99 parts by weight, and the content of hydroxymethyltriethoxysilane is 0.1-10 parts by weight, the content of the silicone liquid is 0.5-50 parts by weight, the above reagents are pre-cooled in an ice bath, and the preparation process is carried out in an ice bath.
[0056] (2) Mix the catal...
Embodiment 2
[0061] A composition and preparation method of a hydrophobic polymer hemostatic repair material that can quickly adhere to a wet tissue interface, comprising the following steps:
[0062] (1) Select polyacrylate as molding agent, which includes coupling unit ethyl acrylate and catalytic unit Irgacure2959 or α-ketoglutaric acid (photocatalyst), silicone liquid (viscosity: 200mm 2 / s~500000mm 2 / s) As a flowable hydrophobic macromolecule, N-hydroxysuccinimide acrylate is prepared as a tissue crosslinking agent, wherein the content of polyethylacrylate is 50-99 parts by weight, N-hydroxysuccinimide acrylate The content of the urethane is 0.1-1 weight part, and the content of the silicone liquid is 0.5-50 weight parts. The above reagents are pre-cooled in an ice bath, and the preparation process is carried out in the ice bath.
[0063] (2) Mix the catalytic unit: Irgacure 2959 or α-ketoglutaric acid with N-hydroxysuccinimide acrylate in parts by weight of 99.99-10:0.01-90, as com...
Embodiment 3
[0068] A composition and preparation method of a hydrophobic polymer hemostatic repair material that can quickly adhere to a wet tissue interface, comprising the following steps:
[0069] (1) Select polyacrylate as forming agent, which includes coupling unit ethyl acrylate and catalytic unit butanone peroxide or 1,1-bis(tert-butylperoxy)-3,3,5-trimethyl ring Hexane (hot catalyst), silicone liquid (viscosity: 200mm 2 / s~500000mm 2 / s) As a flowable hydrophobic macromolecule, N-hydroxysuccinimide acrylate is prepared as a tissue crosslinking agent, wherein the content of polyethylacrylate is 50-99 parts by weight, N-hydroxysuccinimide acrylate The content of the urethane is 0.1-1 weight part, and the content of the silicone liquid is 0.5-50 weight parts. The above reagents are pre-cooled in an ice bath, and the preparation process is carried out in the ice bath.
[0070] (2) The catalytic unit: butanone peroxide or 1,1-bis(tert-butylperoxy)-3,3,5-trimethylcyclohexane and N-hyd...
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