Hydrophobic polymer hemostatic repair material and preparation method and application thereof

A technology of hydrophobic polymers and repair materials, which can be used in applications, pharmaceutical formulations, bandages, etc., can solve problems such as interface bonding failure, and achieve strong adhesion, good application prospects, and good tissue adhesion.

Active Publication Date: 2021-11-05
重庆市沙坪坝区中智医谷研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most bioadhesives are hydrophilic materials, and their water absorption and swelling often lead to failure of interfacial bonding
Therefore, there is an urgent need to develop a gel adhesive suitable for wet environments with short curing time, strong instant adhesion, and strong water resistance, so as to solve the shortcomings and deficiencies of existing tissue adhesives on the market.

Method used

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  • Hydrophobic polymer hemostatic repair material and preparation method and application thereof
  • Hydrophobic polymer hemostatic repair material and preparation method and application thereof
  • Hydrophobic polymer hemostatic repair material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A composition and preparation method of a hydrophobic polymer hemostatic repair material that can quickly adhere to a wet tissue interface, comprising the following steps:

[0055] (1) Select polyurethane as forming agent, which includes coupling unit aliphatic diisocyanate (such as 1,6-hexamethylene diisocyanate) and polymer polyol (such as polycarbonate diol) and catalytic unit dimethylaminoethoxy Ethanol or trimethylhydroxypropyl ethylenediamine (small molecule catalyst), silicone liquid (viscosity: 200mm 2 / s~500000mm 2 / s) As a flowable hydrophobic macromolecule, hydroxymethyltriethoxysilane is prepared as a tissue crosslinking agent, wherein the polyurethane content is 40 to 99 parts by weight, and the content of hydroxymethyltriethoxysilane is 0.1-10 parts by weight, the content of the silicone liquid is 0.5-50 parts by weight, the above reagents are pre-cooled in an ice bath, and the preparation process is carried out in an ice bath.

[0056] (2) Mix the catal...

Embodiment 2

[0061] A composition and preparation method of a hydrophobic polymer hemostatic repair material that can quickly adhere to a wet tissue interface, comprising the following steps:

[0062] (1) Select polyacrylate as molding agent, which includes coupling unit ethyl acrylate and catalytic unit Irgacure2959 or α-ketoglutaric acid (photocatalyst), silicone liquid (viscosity: 200mm 2 / s~500000mm 2 / s) As a flowable hydrophobic macromolecule, N-hydroxysuccinimide acrylate is prepared as a tissue crosslinking agent, wherein the content of polyethylacrylate is 50-99 parts by weight, N-hydroxysuccinimide acrylate The content of the urethane is 0.1-1 weight part, and the content of the silicone liquid is 0.5-50 weight parts. The above reagents are pre-cooled in an ice bath, and the preparation process is carried out in the ice bath.

[0063] (2) Mix the catalytic unit: Irgacure 2959 or α-ketoglutaric acid with N-hydroxysuccinimide acrylate in parts by weight of 99.99-10:0.01-90, as com...

Embodiment 3

[0068] A composition and preparation method of a hydrophobic polymer hemostatic repair material that can quickly adhere to a wet tissue interface, comprising the following steps:

[0069] (1) Select polyacrylate as forming agent, which includes coupling unit ethyl acrylate and catalytic unit butanone peroxide or 1,1-bis(tert-butylperoxy)-3,3,5-trimethyl ring Hexane (hot catalyst), silicone liquid (viscosity: 200mm 2 / s~500000mm 2 / s) As a flowable hydrophobic macromolecule, N-hydroxysuccinimide acrylate is prepared as a tissue crosslinking agent, wherein the content of polyethylacrylate is 50-99 parts by weight, N-hydroxysuccinimide acrylate The content of the urethane is 0.1-1 weight part, and the content of the silicone liquid is 0.5-50 weight parts. The above reagents are pre-cooled in an ice bath, and the preparation process is carried out in the ice bath.

[0070] (2) The catalytic unit: butanone peroxide or 1,1-bis(tert-butylperoxy)-3,3,5-trimethylcyclohexane and N-hyd...

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Abstract

The invention relates to a hydrophobic polymer hemostatic repair material and a preparation method and application thereof. The repair material can be rapidly adhered to a moist tissue interface and comprises a component A and a component B. The component A comprises a catalytic unit and a tissue cross-linking agent, and the component B comprises flowable hydrophobic macromolecules and a coupling unit; and the catalytic unit and the coupling unit form a forming agent. According to the hydrophobic polymer hemostatic repair material disclosed by the invention, rapid adhesion to the moist tissue interface is realized by virtue of strong drainage capacity of hydrophobic macromolecules, rapid underwater gelling capacity of the forming agent and cross-linking reaction of the tissue cross-linking agent to the tissue interface. The hydrophobic polymer hemostatic repair material provided by the invention has the advantages of good tissue adhesion, strong plasticity and good biocompatibility, can effectively promote the repair and healing of wounds and wounds, and has good clinical application prospects in the aspects of hemostasis and repair of tissues and organs such as blood vessels, skin, heart, lung, bone and the like.

Description

technical field [0001] The invention relates to a hydrophobic polymer hemostatic repair material capable of quickly adhering to a wet tissue interface, a preparation method and application thereof, and belongs to the technical field of biomedical materials. Background technique [0002] For a long time, traumas caused by traffic accidents, natural disasters, battlefields, etc., such as bleeding and damage to tissues and organs such as bones, cardiovascular, liver, and lungs, usually cannot heal by themselves and require surgical treatment to recover. Wound suturing with sutures, rivets, etc. is the most commonly used and effective method in clinical practice. The suture is firm and the wound is not easy to crack. However, surgical suturing also faces many problems, including 1) it will cause secondary trauma such as wound scarring, pain, and inflammatory reactions; 2) it is difficult to suture some visceral surface injuries, and the sutures are not easy to degrade or degrade...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/06A61L24/00A61L15/26A61L15/24A61L15/20A61L15/44A61L15/42
CPCA61L24/046A61L24/06A61L24/0015A61L24/001A61L15/26A61L15/24A61L15/20A61L15/44A61L15/42A61L2400/04A61L2300/412C08L75/04C08L33/08C08L83/04
Inventor 邢孟秋朱楚洪刘雨青李英豪
Owner 重庆市沙坪坝区中智医谷研究院
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