Antibacterial composite coating as well as preparation method and product thereof

A composite coating, antibacterial coating technology, applied in coatings, pharmaceutical formulations, catheters, etc., to achieve good lubricity, reduce the development of bacterial resistance, and good firmness.

Active Publication Date: 2021-11-26
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current method still needs to be improved in terms of the firmness of the micr

Method used

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  • Antibacterial composite coating as well as preparation method and product thereof
  • Antibacterial composite coating as well as preparation method and product thereof
  • Antibacterial composite coating as well as preparation method and product thereof

Examples

Experimental program
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Example Embodiment

[0131] These antibacterial molecule or functional group mainly by esterification, transesterification, amidation reaction, the reaction click, protonation reaction, ionic reaction, ring opening reactions, addition reactions, elimination reactions, aldol reactions, initiation introduction of the polymerization reaction or the like. For example, adamantane and PHMG chloride (polyhexamethylene guanidine hydrochloride) introducing a substituted guanidinium group occurs; 6-bromo-β- cyclodextrin and quaternary aminoethanol ammonium reactions introducing a quaternary ammonium group; bovine serum albumin and allyl bromide click reaction introducing serum proteins and the like. In some embodiments of the invention, the functions of the guest molecule and / or the main body of the molecule as a functional molecule, more preferably a modified cyclodextrin guanidine salts and / or quaternary ammonium modified cyclodextrin, cyclodextrins generally contain 6 to 12 D- glucopyranose units, typica...

Example Embodiment

[0140] Preparation Example 1: Preparation of hydroxyethyl methacrylate

[0141] In a 250 mL three-flavor equipped with mechanical stirring, 26.0 g of hydroxyethyl methacrylate (0.2 mol), 100 ml of dried dichloromethane and 25.3 g of triethylamine (0.25 mol) were added, and slow drops with constant pressure drip funnel Add 21.7 g of acryloyl chloride (0.24 mol), at 0 ° C for 0.5 hours, the temperature above 28 ° C for 10 hours, the crude product was filtered, and the crude product was separated from the column chromatography, dried 30.2 g of yellow sheet crystal, methyl methacrylate Ethyl acrylate, such as structural formula, yield 82%. 1 H NMR (CDCL 3 ) δ: 6.44 (m, 1h, ch 2 = CH), 6.10 (m, 2H, CH 2 = CH, CH = CH), 5.84 (M, 1H, CH 2 = CH), 5.58 (M, 1H, CH = CH), 4.38 (M, 4H, COOCH 2 CH 2 OCO), 1.94 (S, 3H, CH 3 .

[0142]

Example Embodiment

[0143] Preparation 2: Preparation of Benzophenone-2-aminopropylthyl methacrylate (IIA)

[0144] 18.4 g (0.1 mol) Preparation Example 1 made of methyl methacrylate hydroxyethyl acrylate was added to a 250 ml of three flasks, 100 mL of ethanol was added, and stirred, 19.7 g (0.1 mol) 4-amino group was added. Benzophenone, temperature rise to 60 ° C for 14 hours. The reaction liquid was dried, and the crystallization of ethanol and ethyl acetate was recrystallized to give 34 g of pale yellow solid, and the yield was 90%. 1 HNMR (CDCL 3 ) δ: 7.32-7.87 (M, 9H, benzene ring), 6.42-6.48 (m, 2H, CH 2 = CH), 4.78 (S, 2H, -CH 2 -CH 2 -O), 4.32 (S, 2H, -CH 2 -CH 2 -O), 3.62 (m, 2H, NH-CH 2 -CH 2 -), 2.58 (m, 2H, NH-CH 2 -CH 2 -), 2.01 (s, 3h, ch 3 ), Specifically, see figure 1 .

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Abstract

The invention relates to an antibacterial composite coating as well as a preparation method and a product thereof. The antibacterial composite coating comprises at least one layer of hydrophilic coating and at least one layer of antibacterial coating, the at least one layer of hydrophilic coating is obtained by photocuring a coating composition containing a host and/or a guest structural unit, the at least one layer of antibacterial coating comprises a guest molecule and/or host modified by antibacterial functionalization molecular, and the at least one layer of hydrophilic coating and the at least one layer of antibacterial coating produce host-guest interactions. The antibacterial composite coating is high in firmness, stability and antibacterial rate, and has good lubricity.

Description

technical field [0001] The invention belongs to the technical field of photocuring and coating, and in particular relates to an antibacterial composite coating, a preparation method and a product thereof. Background technique [0002] The adhesion of bacteria on the surface of biomaterials and the subsequent formation of biofilms can cause a series of biological infection problems such as implantation failure of medical devices, tissue infection and inflammation. How to solve the infection related to biomaterials is an urgent problem to be solved in the development of interventional devices. Improving the antibacterial effect of medical devices is one of the ways to try. [0003] At present, the means to improve the antibacterial performance of medical devices mainly include: 1) Embedding and adsorbing antibacterial substances in the substrate of medical devices or its surface coating, and releasing antibacterial substances to kill pathogenic bacteria, thereby playing an an...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L29/16A61L31/10A61L31/14A61L31/16
CPCA61L29/085A61L29/14A61L29/16A61L31/10A61L31/14A61L31/16A61L2300/404A61L2300/606A61L2420/02A61L2420/08A61L2400/10C08L39/06C08L5/16
Inventor 雷杰华唐增超杜慧李丹陈红
Owner JIANGSU BIOSURF BIOTECH CO LTD
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