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Antibacterial composite coating as well as preparation method and product thereof

A composite coating, antibacterial coating technology, applied in coatings, pharmaceutical formulations, catheters, etc., to achieve good lubricity, reduce the development of bacterial resistance, and good firmness.

Active Publication Date: 2021-11-26
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current method still needs to be improved in terms of the firmness of the micro-nano structure or antibacterial coating, and the reduction of bacterial adhesion.

Method used

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  • Antibacterial composite coating as well as preparation method and product thereof
  • Antibacterial composite coating as well as preparation method and product thereof
  • Antibacterial composite coating as well as preparation method and product thereof

Examples

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preparation example Construction

[0131] These groups or molecules with antibacterial function mainly undergo esterification reaction, transesterification reaction, amidation reaction, click reaction, protonation reaction, ionization reaction, ring opening reaction, addition reaction, elimination reaction, aldol reaction, initiation Polymerization etc. are introduced. For example, the substitution of adamantanoyl chloride and PHMG (polyhexamethyleneguanidine hydrochloride) introduces guanidinium salt groups; the quaternization reaction of 6-bromoβ-cyclodextrin and aminoethanol introduces quaternary ammonium groups; bovine serum albumin and allyltrimethylammonium bromide click reaction to introduce serum proteins, etc. In some embodiments of the present invention, the functionalized guest molecule and / or host molecule is a functionalized host molecule, more preferably a guanidinium salt modified cyclodextrin and / or a quaternary ammonium salt modified cyclodextrin, Cyclodextrins usually contain 6 to 12 D-glucop...

preparation example 1

[0140] Preparation example 1: Preparation of methacrylate hydroxyethyl acrylate

[0141] In a 250mL three-necked flask equipped with mechanical stirring, add 26.0g of hydroxyethyl methacrylate (0.2mol), 100mL of dry dichloromethane and 25.3g of triethylamine (0.25mol), and slowly drop it with a constant pressure dropping funnel Add 21.7g of acryloyl chloride (0.24mol), react at 0°C for 0.5 hours, raise the temperature to 28°C for 10 hours, filter the crude product, separate and purify the crude product by column chromatography, and obtain 30.2g of yellow flaky crystals after drying. Ethyl acrylate is shown in structural formula 1, and the yield is 82%. 1 H NMR (CDCl 3 )δ:6.44(m,1H,CH 2 =CH),6.10(m,2H,CH 2 =CH, CH=CH), 5.84 (m, 1H, CH 2 =CH), 5.58(m, 1H, CH=CH), 4.38(m, 4H, COOCH 2 CH 2 OCO), 1.94(s, 3H, CH 3 ).

[0142]

preparation example 2

[0143] Preparation example 2: Preparation of benzophenone-2-aminopropyl ethyl methacrylate (IIa)

[0144] Add 18.4g (0.1mol) of methacrylate hydroxyethyl acrylate prepared in Preparation Example 1 into a 250mL three-necked flask, add 100mL of ethanol and stir, and after it is completely dissolved, add 19.7g (0.1mol) of 4-aminodimethacrylate Benzophenone was heated to 60°C for 14 hours. The reaction solution was spin-dried, and recrystallized from ethanol and ethyl acetate to obtain 34 g of a light yellow solid with a yield of 90%. 1 HNMR (CDCl 3 )δ: 7.32-7.87 (m, 9H, benzene ring), 6.42-6.48 (m, 2H, CH 2 =CH), 4.78(s,2H,-CH 2 -CH 2 -O),4.32(s,2H,-CH 2 -CH 2 -O), 3.62(m, 2H, NH-CH 2 -CH 2 -), 2.58 (m, 2H, NH-CH 2 -CH 2 -), 2.01(s, 3H, CH 3 ), see the specific map figure 1 .

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Abstract

The invention relates to an antibacterial composite coating as well as a preparation method and a product thereof. The antibacterial composite coating comprises at least one layer of hydrophilic coating and at least one layer of antibacterial coating, the at least one layer of hydrophilic coating is obtained by photocuring a coating composition containing a host and / or a guest structural unit, the at least one layer of antibacterial coating comprises a guest molecule and / or host modified by antibacterial functionalization molecular, and the at least one layer of hydrophilic coating and the at least one layer of antibacterial coating produce host-guest interactions. The antibacterial composite coating is high in firmness, stability and antibacterial rate, and has good lubricity.

Description

technical field [0001] The invention belongs to the technical field of photocuring and coating, and in particular relates to an antibacterial composite coating, a preparation method and a product thereof. Background technique [0002] The adhesion of bacteria on the surface of biomaterials and the subsequent formation of biofilms can cause a series of biological infection problems such as implantation failure of medical devices, tissue infection and inflammation. How to solve the infection related to biomaterials is an urgent problem to be solved in the development of interventional devices. Improving the antibacterial effect of medical devices is one of the ways to try. [0003] At present, the means to improve the antibacterial performance of medical devices mainly include: 1) Embedding and adsorbing antibacterial substances in the substrate of medical devices or its surface coating, and releasing antibacterial substances to kill pathogenic bacteria, thereby playing an an...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L29/16A61L31/10A61L31/14A61L31/16
CPCA61L29/085A61L29/14A61L29/16A61L31/10A61L31/14A61L31/16A61L2300/404A61L2300/606A61L2420/02A61L2420/08A61L2400/10C08L39/06C08L5/16
Inventor 雷杰华唐增超杜慧李丹陈红
Owner JIANGSU BIOSURF BIOTECH CO LTD
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