Co-production preparation method of ceramide and glucoside (lipoyl) sphingosine

A technology of ceramide and sphingosine is applied in the preparation of sugar derivatives, chemical instruments and methods, separation/purification of carboxylic acid amides, etc. The effect of improving the comprehensive utilization rate of resources and improving the prospect of industrial application

Pending Publication Date: 2021-12-14
绵阳膳意生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ceramides and glucoside (fat) ceramides exist in the cell membranes of animal and plant tissues and come from a wide range of sources. However, due to the risk of pathogenic factors associated with animal-derived ceramide products, their market acceptance is limited, so It is of great significance to extract ceramide and glucoside (fat) ceramide from plants

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 uses konjac flying powder as raw material coproduction to prepare ceramide and glucoside (fat) ceramide

[0028] Get 1000 grams of by-product konjac flying powder in the processing of konjac fine powder, use 6 times the amount of 80% ethanol to stir and heat to extract three times and filter (the filter cake can be used for making feed through drying), merge three extractions, add milk of lime to adjust the pH value to 10.0, a large amount of fatty acid calcium precipitates, let it stand for 3-5 hours, filter out the fatty acid calcium, adjust the pH of the filtrate to 5.0 with hydrochloric acid (concentrated hydrochloric acid is diluted with water at a volume ratio of 1:1), concentrate and recover ethanol until it has no alcohol smell, Add an equal volume of water to the concentrated solution to obtain a solution, and then use petroleum ether / methanol / glacial acetic acid mixed organic solvent to carry out fractional extraction, and the volume ratio of petro...

Embodiment 2

[0029] Example 2 Co-production of ceramide and glucoside (fat) ceramide with rice bran residue as raw material

[0030] Get 1000 grams of rice bran residue after rice oil processing, stir and heat extraction three times with 8 times the amount of 90% ethanol and filter (the filter cake can be used to make feed after drying), combine three extractions, add milk of lime to adjust the pH value to 10.0, resulting in a large amount of Fatty acid calcium precipitates, let it stand for 2-4 hours, filter to remove fatty acid calcium, adjust the pH of the filtrate to 5.0 with hydrochloric acid (concentrated hydrochloric acid is diluted with water at a volume ratio of 1:1), concentrate and recover ethanol until there is no alcohol smell, and add to the concentrated solution 1.5 times the volume of water to obtain a solution, and then use dichloromethane / methanol / glacial acetic acid mixed organic solvent to carry out fractional extraction, and the volume ratio of dichloromethane / methanol / ...

Embodiment 3

[0031] Example 3 Co-production of ceramide and glucoside (fat) ceramide with konjac powder as raw material

[0032] Get 1000 grams of by-product konjac flying powder in the processing of konjac fine powder, use 4 times the amount of 95% ethanol to stir and heat to extract three times and filter (the filter cake can be used for making feed through drying), merge three extractions, add milk of lime to adjust the pH value to 11.0, a large amount of fatty acid calcium precipitates, let it stand for 6-8 hours, filter out the fatty acid calcium, adjust the pH of the filtrate to 6.0 with 2M sulfuric acid, concentrate and recover ethanol until there is no alcohol smell, add 2 times the volume of water to the concentrated solution, and obtain a solution , and then use the mixed organic solvent of cyclohexane / methanol / glacial acetic acid to carry out fractional extraction, and the volume ratio of cyclohexane / methanol / glacial acetic acid is 10:1:0.1, 10:2:0.3, 10:3:0.6 , 10:4:0.8, 10:5:1.0...

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PUM

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Abstract

The invention provides a co-production preparation method of ceramide and glucoside (lipoyl) sphingosine, which comprises the following steps: taking konjak flying powder or rice bran residue as a raw material, and sequentially extracting, adjusting the pH value, filtering, adjusting the pH value, concentrating, extracting, recrystallizing and the like to obtain high-purity free ceramide and glucoside (lipoyl) sphingosine. According to the co-production preparation method of ceramide and glucoside (lipoyl) sphingosine, the konjac flying powder and the rice bran residues are turned into wealth for resource reutilization to produce ceramide and glucoside (lipoyl) sphingosine with high economic values, so that the comprehensive utilization rate of resources is improved, and the method has huge economic benefits and environmental benefits.

Description

technical field [0001] The invention relates to a method for jointly producing ceramide and glucoside (fat) ceramide by using konjac powder or rice bran residue as raw materials, and belongs to the technical field of deep processing of agricultural and sideline products. Background technique [0002] Ceramides, also known as sphingolipids, are lipids present in the skin and play an important role in the formation of the stratum corneum of the epidermis. It is a common structural unit of (nerve) sphingolipids. Fatty acid has an acid amide bond structure on the amino group of sphingosine. If it is combined with sugar, it will become glycosphingolipids, and if it is combined with phosphorylcholine, it will become (nervous) sphingomyelin. Ceramide is an intermediate metabolite of sphingolipids, especially in biosynthesis. Ceramide exists in the cell membrane of animal and plant tissues, and its molecules expose monosaccharide or oligosaccharide residues to the extracellular s...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07H15/10C07C231/24C07C233/18C07C235/08
CPCC07H1/08C07H15/10C07C231/24C07C233/18C07C235/08
Inventor 吴宪君刘玲蒋昊月吴昱隆
Owner 绵阳膳意生物科技有限公司
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