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Dressing composition as well as preparation method and application thereof

A composition and dressing technology, applied in the field of biomedical engineering, can solve problems such as inability to observe wounds, wound coloring, and affect patient compliance, and achieve the effects of maintaining a moist healing environment, reducing scar formation, and accelerating wound healing

Pending Publication Date: 2021-12-31
블라파르바이오테크놀로지항저우리미티드
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional medical dressings, including cotton gauze, non-woven fabrics, etc., have the advantages of easy access to materials, simple production, and low price when used on wounds, but they also have obvious disadvantages: the absorption is small, that is, when the wound surface seeps When there is a lot of liquid, it needs to be replaced frequently; if the permeability is too high, it is easy to dehydrate the wound or be polluted by external dust; the adhesion of the dressing to the wound will bring pain in dressing change and potential secondary trauma, and it is not good for the treatment of refractory wounds such as ulcers. Be applicable
Its disadvantages include: it is not suitable for wounds with more exudate, it is not suitable for wounds with fragile surrounding skin due to potential surrounding skin damage during removal, and it is not recommended for deep sneak wounds, etc.
But it also has some disadvantages: it is not conducive to its own debridement process when used on low-exudation wounds, it is impossible to observe the wound due to opacity, and the cost of use is relatively high
However, the disadvantages of ionic dressings are: the products on the market have basically no ability to absorb exudate, are easy to cause coloring on the wound, may cause silver ion allergy, and have potential liver and kidney damage risks after long-term use.
[0008] At present, medical hydrocolloid or hydrogel dressings on the market mainly use functional ingredients such as chitosan, sodium alginate, and silver ions. These products have poor wound healing ability, ineffective anti-inflammatory, hemostatic, and pain-relieving effects, and are safe. It needs to be re-evaluated, especially for various chronic body surface wounds, including ulcers, diabetic feet, lower extremity venous / arterial ulcers, pressure sores, burns and scalds. The effective time of wound treatment cannot satisfy the patient, and the treatment process may make the patient feel painful , affecting patient compliance

Method used

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  • Dressing composition as well as preparation method and application thereof
  • Dressing composition as well as preparation method and application thereof
  • Dressing composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0038] Preparation Example 1 Preparation of Medical Dressing Skeleton Material

[0039] Take 2.2g of PLGA (type 50-50, weight average molecular weight 15000Da) and dissolve it in an appropriate amount of ethyl acetate to obtain a PLGA solution;

[0040] Take 9.3g of cross-linked sodium hyaluronate (weight average molecular weight 2000kDa) and 0.95g of sodium hyaluronate (weight average molecular weight 300kDa), put them in an appropriate amount of water, and stir at 60±5°C until homogenized;

[0041] Add PLGA solution to the homogenized solution of cross-linked sodium hyaluronate and sodium hyaluronate at 60°C±5°C with stirring, stir until homogenized, adjust the pH to about 7 with triethanolamine and / or acetic acid, Freeze-dry until the water content is within 10%, and grind the obtained freeze-dried product into a fine powder passing through a 60-mesh sieve to obtain 13.5 g of medical dressing skeleton material A. Among them, the content of cross-linked sodium hyaluronate i...

preparation example 2

[0042] Preparation Example 2 Preparation of Medical Dressing Skeleton Material

[0043] Take 2.45g of PLGA (type 50-50, weight average molecular weight 15000Da), dissolve it in an appropriate amount of ethyl acetate to obtain a PLGA solution;

[0044] Take 11.75g ​​of cross-linked sodium hyaluronate (weight average molecular weight 2000kDa) and 0.96g of sodium hyaluronate (weight average molecular weight 300kDa), put them in an appropriate amount of water, and stir at 60±5°C until homogenized;

[0045] Add PLGA solution to the homogenized solution of cross-linked sodium hyaluronate and sodium hyaluronate at 60°C±5°C with stirring, stir until homogenized, adjust the pH to about 7 with triethanolamine and / or acetic acid, Freeze-dry until the water content is within 10%, and grind the obtained freeze-dried product into a fine powder passing through an 80-mesh sieve to obtain 16.5 g of medical dressing skeleton material B. Among them, the content of cross-linked sodium hyaluronat...

Embodiment 3 Embodiment 1-2

[0054] The antibacterial effect of embodiment 3 embodiment 1-2 medical dressing

[0055] With reference to the provisions in GB / T15979-2002 "Hygienic Standards for Disposable Sanitary Products" Appendix C product bactericidal performance, antibacterial performance and stability test method, the dressing prepared in embodiment 1-2, the commercially available dressing product (comparative example 1, trade name: Kanghuier debridement gel, Coloplast China Medical Supplies Co., Ltd.), dressing (comparative example 2) made by mixing other components except skeleton material A in Example 1, negative control (PBS solution ) were tested in vitro.

[0056] Test bacteria: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans.

[0057] The test method is as follows: respectively prepare the above test bacteria with a concentration of 10 4 -10 5 cfu / g bacterial suspension. Get 0.1mL of bacterial suspension and apply it evenly on the sheet-shaped (2.0cm×3.0cm...

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Abstract

The invention relates to a dressing composition as well as a preparation method and application thereof, in particular to a dressing composition prepared by taking hyaluronic acid (sodium hyaluronate), cross-linked hyaluronic acid (sodium hyaluronate) and a polylactic acid-glycolic acid copolymer as a framework as well as a preparation method and application of the dressing composition. The dressing composition disclosed by the invention also contains poloxamer, carbomer, benzyl alcohol and propylene glycol.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and specifically relates to a dressing composition and its preparation method and application, especially a dressing composition made of hyaluronic acid (sodium), cross-linked hyaluronic acid (sodium) and PLGA as the skeleton. Dressing composition and method for its preparation and use. Background technique [0002] Traditional medical dressings, including cotton gauze, non-woven fabrics, etc., have the advantages of easy access to materials, simple production, and low price when used on wounds, but they also have obvious disadvantages: the absorption is small, that is, when the wound surface seeps When there is a lot of liquid, it needs to be replaced frequently; if the permeability is too high, it is easy to dehydrate the wound or be polluted by external dust; the adhesion of the dressing to the wound will bring pain in dressing change and potential secondary trauma, and it is no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L15/20A61L15/24A61L15/26A61L15/28A61L15/42A61L15/46
CPCA61L26/0023A61L26/0019A61L26/0014A61L26/008A61L26/0061A61L15/28A61L15/26A61L15/24A61L15/20A61L15/42A61L15/46C08L5/08C08L67/04C08L71/02C08L33/02
Inventor 赵海光李静薛秀生阿斯根徐倩王文新徐勇猛
Owner 블라파르바이오테크놀로지항저우리미티드
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