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Spinous nanogold@silver based triple amplification SERS signal substrate as well as preparation method and application of SERS signal substrate

A nano-gold, re-amplification technology, applied in the direction of measuring devices, instruments, and material analysis through optical means, can solve the problems of large SERS signal amplification effect, lack of integration of several aspects of parameters, poor stability and repeatability, etc., to achieve Guaranteed stability and repeatability, novel structure, and improved sensitivity

Active Publication Date: 2021-12-31
HANGZHOU NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the current research work, the method of amplifying SERS signal mainly focuses on adjusting the structure, composition or roughness of nanoparticles in the substrate, and does not integrate several parameters to achieve the theoretical maximum SERS signal amplification effect.
In addition, there are still problems of poor stability and repeatability in SERS detection, and quantitative detection is difficult

Method used

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  • Spinous nanogold@silver based triple amplification SERS signal substrate as well as preparation method and application of SERS signal substrate
  • Spinous nanogold@silver based triple amplification SERS signal substrate as well as preparation method and application of SERS signal substrate
  • Spinous nanogold@silver based triple amplification SERS signal substrate as well as preparation method and application of SERS signal substrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Preparation of gold nanoparticles spiny

[0044] Synthesis of Nano-gold ball seed, sodium citrate classic acid prepared nanoscaled gold reduction silky seed. Distilled water was poured into a 140mL three-neck flask, and setting up the condensing device, the set temperature 137 ℃, 1000rpm; sodium citrate was weighed 0.1g in 10mL water, adding three-necked flask was heated to boiling; then rapidly injected 1mL 25mM chlorine acid solution, after the addition of no significant color change, Tris solution was added after 60s, after the addition of the solution changed from colorless to pale pink quickly, then becomes pink, kept boiling for 15min after cooling to 100 deg.] C; then quickly injected in 1mL 25mM chloroauric acid solution, maintaining the temperature 20min; finally, rapidly injecting 1mL 25mM chloride acid solution, maintaining the temperature 20min, allowed to cool, a solution prepared by nano-gold ball. TEM images such as nano-gold ball figure 1 Indicated by A,...

Embodiment 2

[0058] Silver has a great influence on the thickness of the shell of the spinous based nano SERS signal amplified triplet base sensitivity @ gold silver. And silver nitrate solution was added ascorbic acid solution of different volumes, to explore the range of the thickness of the silver shell.

[0059] According to the procedure of Example 1 (1) Preparation of gold nanoparticles prepared spiny solution. In spinous gold nanoparticles as control samples a. Take 5mL spinous nano-gold solution, dispersed in an ultrasonic 0.08M solution of CTAC, centrifugation spiny nano-gold layer, triplicate. Subsequently, the spinous layer of gold nanoparticles were added 0.05,0.1,0.2,0.4,0.8mL of 0.01M silver nitrate solution, ultrasonic dispersion, and then the corresponding ascorbic acid solution was added 0.1M of 0.025,0.05,0.1,0.2,0.4mL after ultrasonic dispersion again, 65 deg.] C water bath for 4h, cooled to room temperature. Prepared five different spiny @ silver nano-gold sample b-f. Spiny...

Embodiment 3

[0061] Research etching time based on the influence of the spinous nano SERS signal amplified triplet base sensitivity @ gold and silver.

[0062] According to the procedure of Example 1 (1) - (4) Preparation of gold nanoparticles prepared spiny @ dimensional silver monolayer film - silicon.

[0063] The spiky silver nano-gold-dimensional monolayer films @ - was immersed into an etching solution after the etching, respectively 20,40,60,80,100,120s, removed out for cleaning and dried to give six kinds of gold nano-based spiny silver @ SERS signal amplified triplet base. Sample is not etched simultaneously with the operation of the control group, referred to as etching 0s. Composition 4 had a 30% hydrogen peroxide, ammonia, methanol: said etching solution by a volume ratio of 1: 1. Control group prepared based on different substrate and nano-gold @ spiny silver SERS signal amplified triplet base six kinds.

[0064] The control group based on different substrate and nano-gold @ spiny...

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Abstract

The invention discloses a spinous nanogold@silver based triple amplification SERS signal substrate, the substrate comprises a spinous nanogold@silver two-dimensional single-layer film with a roughened surface and a substrate, and the spinous nanogold@silver two-dimensional single-layer film with the roughened surface is a spinous nanogold@silver two-dimensional single-layer film subjected to surface roughening treatment; the spiny nanogold@silver two-dimensional single-layer film is provided with a spiny nanogold@silver two-dimensional array, and the spiny nanogold@silver is provided with a core-shell structure that spiny nanogold is coated with silver. The spinous nanogold@silver two-dimensional single-layer film is prepared in a liquid-liquid interface self-assembly mode, the spinous nanogold@silver two-dimensional single-layer film is subjected to surface roughening treatment to prepare the substrate, SERS signals are superposed and enhanced from the three aspects of material components, a plasmon structure and surface roughness, and triple amplification of the SERS signals and improvement of detection sensitivity are achieved. The substrate based on thorn-shaped nanogold and silver triple amplification SERS signals is good in detection stability and repeatability and can be applied to the field of pesticide residue detection.

Description

Technical field [0001] The present invention relates to a nano-material science and laser Raman detection technology, and particularly relates to gold nanoparticles based spiny @ silver SERS signal amplified triplet base, preparation method and application. Background technique [0002] Surface enhanced Raman scattering (SERS) effect can be enhanced Raman signal molecule one million times or more times, a fingerprint having a high sensitivity of spectroscopic techniques, rapid, sensitive, non-isolated, label-free detection of various target Analyte. SERS detection of high sensitivity can be achieved by detection of single molecule level. Such ultra-enhanced chemical enhancement and spectral localized surface (the LSPR) dependent on the physical effect that generally enhanced plasmon resonance. Hot SERS surface plasmon resonance in the gap by the noble metal nanostructures (<10nm), the edges, corners, or the like tip induced by a position having a strong point of the local elec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 黄又举宋丽平丁彩萍肖志东刘会芹
Owner HANGZHOU NORMAL UNIVERSITY