Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof

A technology of glabridin and nanoemulsion, which is applied in the field of daily chemicals to achieve the effects of good biocompatibility, increased compatibility and inhibition of tyrosinase production

Pending Publication Date: 2022-01-07
湖北省麦诗特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few studies on increasing the scope of transdermal delivery of glabridin. Based on the high-efficiency wh

Method used

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  • Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof
  • Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof
  • Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0039] Example 1-3

[0040] A whitening essence based on phospholipid wrapped glycopathy, its raw material group distribution ratio, the content ratio of the ratio raw material group, as shown in Table 1 below.

[0041] Table 1 Embodiment of the raw material group distribution ratio (unit: mass%)

[0042]

[0043]

[0044] The above-mentioned steps of the following steps:

Example Embodiment

[0045] Example 1:

[0046] 1) Preparation of luminosilica-mamminated glycove wrapped in phospholipid:

[0047] The phospholipid and glycove were dissolved in acetone in acetone at 35 ° C, and the resulting solution was removed even under 35 ° C. Tween 20, the emulsifier ethylene glycol, the oil phase olive oil, the luminosilic phospholipid complex is ultrasonically mixed with deionized water into the high pressure homogeneous machine, and set the pressure of 100 MPa, homogeneity at 25 ° C. Natural nano milk can be obtained.

[0048] 2) Glycerol, glycyrrhizinate, acetyl glucosamine, xanthan gum, sodium acrylate / acryl dimethylsulfonate copolymer, 1,3-butanediol, is well dispersed in water. Have a mixture;

[0049]3) Mixing in step 2) Add a proportion of phospholipids wrapped in luminosil, ishylacetinate, smexine, dimethylsilicone oil, isodoxane, hydroxythylidetone , Phenoxethanol and EDTA-2NA are heated to 65 ° C, and 3000 r / min homogeneous 3 minutes is completely dispersed;

[...

Example Embodiment

[0051] Example 2:

[0052] 1) Preparation of luminosilica-mamminated glycove wrapped in phospholipid:

[0053] The phospholipid and luminatine were dissolved in acetone by mass ratio of 10: 1, and stirred even under 40 ° C; the resulting solution was sprayed and dried to remove the organic solvent, then lyophilized for 12 h, obtain a lly of phospholipid complex; emulsifier POLOXAMER188, Helded Mulidizer propylene glycol, oil phase soybean oil, luminosilic phospholipid complex ultrasonic mixed with deionized water into the high pressure homogeneous machine, set the pressure of 80 MPa, homogeneity at 25 ° C, ie Get nano milk.

[0054] 2) Glycerol, glycyrrhizinate, acetyl glucosamine, xanthan gum, sodium acrylate / acryl dimethylsulfonate copolymer, 1,3-butanediol, is well dispersed in water. Have a mixture;

[0055] 3) Mixing in step 2) Add a proportion of phospholipids wrapped in luminosil, ishylacetinate, smexine, dimethylsilicone oil, isodoxane, hydroxythylidetone , Phenoxethanol...

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Abstract

The invention discloses whitening essence based on phospholipid-coated glabridin nanoemulsion and a preparation method thereof. The whitening essence is prepared from the following raw materials in percentage by weight: 2-4% of a phospholipid-coated glabridin nanoemulsion, 5-10% of glycerol, 0.1-0.5% of xanthan gum, 0.05-0.15% of EDTA-2NA, 2-8% of 1, 3-butanediol, 0.04-0.12% of sodium stearoyl glutamate, 0.03-0.15% of dipotassium glycyrrhizinate, 0.2-0.4% of p-hydroxyacetophenone, 1-4% of C12-20 alkyl glucoside, 4-10% of isononyl isononanoate, 1-5% of squalane, 1-2% of dimethyl silicone oil, 4-8% of isododecane, 1-3% of a sodium acrylate/acryloyl dimethyl sodium taurate copolymer, 1.2-2.4% of acetyl glucosamine, 0.2-0.6% of phenoxyethanol, 0.001-0.02% of essence and the balance of deionized water. The phospholipid-coated glabridin nanoemulsion is compounded into the essence and has remarkably improved effects on whitening and brightening skin, reducing skin melanin and relieving skin inflammation.

Description

technical field [0001] The invention relates to a skin care product and a preparation method thereof, belonging to the technical field of daily chemicals, and more specifically relates to a whitening essence based on phospholipid-wrapped glabridin nanoemulsion and a preparation method thereof. Background technique [0002] Glabridin is a natural ingredient extracted from Glycyrrhizae glabra, which is widely used in cosmetics. Glabridin has a very ideal whitening effect, and it can inhibit the activities of tyrosinase, dopachrome tautomerase and dihydroxyindole acid oxidase in melanocytes. [0003] Therefore, glabridin has efficient and safe whitening and lightening effects, and its whitening effect is better than arbutin, niacinamide, kojic acid, and VC ethyl ether. It is considered to be the most effective natural whitening ingredient today. By everyone's favor. [0004] Although glabridin has an efficient and safe whitening effect, its insoluble nature limits its wide ap...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/06A61K8/49A61K8/55A61Q19/02
CPCA61K8/498A61K8/553A61K8/922A61K8/068A61Q19/02A61K2800/782A61K2800/413A61K2800/262
Inventor 杨帆周紫燕李沫郭苗周正
Owner 湖北省麦诗特生物科技有限公司
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