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Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof

A technology of glabridin and nanoemulsion, which is applied in the field of daily chemicals to achieve the effects of good biocompatibility, increased compatibility and inhibition of tyrosinase production

Pending Publication Date: 2022-01-07
湖北省麦诗特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few studies on increasing the scope of transdermal delivery of glabridin. Based on the high-efficiency whitening effect of glabridin, it is necessary to conduct research on its modification to expand its clinical use to meet people's needs

Method used

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  • Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof
  • Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof
  • Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof

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Experimental program
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Effect test

Embodiment 1-3

[0040] A whitening essence based on phospholipid-encapsulated glabridin nanoemulsion, its raw material composition ratio, and the content of the raw material composition ratio in the control example are shown in Table 1 below.

[0041] The raw material component distribution ratio (unit: mass %) of table 1 embodiment 1

[0042]

[0043]

[0044] The preparation process of the above-mentioned whitening essence based on phospholipid-encapsulated glabridin nanoemulsion comprises the following steps:

Embodiment 1

[0046] 1) Preparation of phospholipid-coated glabridin nanoemulsion:

[0047] Dissolve phospholipids and glabridin in acetone at a mass ratio of 8:1, and stir evenly at 35°C; spray-dry the resulting solution to remove the organic solvent, and then freeze-dry for 11 hours to obtain the glabridin phospholipid complex; Tween20, co-emulsifier ethylene glycol, oil phase olive oil, glabridin phospholipid complex were ultrasonically mixed and injected into a high-pressure homogenizer together with deionized water, set the pressure at 100Mpa, and homogenized 4 times at 25°C. Nanoemulsion can be obtained.

[0048] 2) Wet and disperse glycerin, dipotassium glycyrrhizinate, acetylglucosamine, xanthan gum, sodium acrylate / sodium acryloyldimethyltaurate copolymer, and 1,3-butanediol in water in proportion, get the mixture;

[0049]3) Add a certain proportion of phospholipid-coated glabridin nanoemulsion, isononyl isononanoate, squalane, simethicone, isododecane, and p-hydroxyacetophenone...

Embodiment 2

[0052] 1) Preparation of phospholipid-coated glabridin nanoemulsion:

[0053] Dissolve phospholipids and glabridin in acetone at a mass ratio of 10:1, and stir evenly at 40°C; spray-dry the resulting solution to remove the organic solvent, and then freeze-dry for 12 hours to obtain the glabridin phospholipid complex; Poloxamer188, co-emulsifier propylene glycol, oil phase soybean oil, glabridin phospholipid complex are ultrasonically mixed and then injected into a high-pressure homogenizer together with deionized water, set the pressure at 80Mpa, and homogenize 4 times at 25°C Obtain nanoemulsion.

[0054] 2) Wet and disperse glycerin, dipotassium glycyrrhizinate, acetylglucosamine, xanthan gum, sodium acrylate / sodium acryloyldimethyltaurate copolymer, and 1,3-butanediol in water in proportion, get the mixture;

[0055] 3) Add a certain proportion of phospholipid-coated glabridin nanoemulsion, isononyl isononanoate, squalane, simethicone, isododecane, and p-hydroxyacetopheno...

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Abstract

The invention discloses whitening essence based on phospholipid-coated glabridin nanoemulsion and a preparation method thereof. The whitening essence is prepared from the following raw materials in percentage by weight: 2-4% of a phospholipid-coated glabridin nanoemulsion, 5-10% of glycerol, 0.1-0.5% of xanthan gum, 0.05-0.15% of EDTA-2NA, 2-8% of 1, 3-butanediol, 0.04-0.12% of sodium stearoyl glutamate, 0.03-0.15% of dipotassium glycyrrhizinate, 0.2-0.4% of p-hydroxyacetophenone, 1-4% of C12-20 alkyl glucoside, 4-10% of isononyl isononanoate, 1-5% of squalane, 1-2% of dimethyl silicone oil, 4-8% of isododecane, 1-3% of a sodium acrylate / acryloyl dimethyl sodium taurate copolymer, 1.2-2.4% of acetyl glucosamine, 0.2-0.6% of phenoxyethanol, 0.001-0.02% of essence and the balance of deionized water. The phospholipid-coated glabridin nanoemulsion is compounded into the essence and has remarkably improved effects on whitening and brightening skin, reducing skin melanin and relieving skin inflammation.

Description

technical field [0001] The invention relates to a skin care product and a preparation method thereof, belonging to the technical field of daily chemicals, and more specifically relates to a whitening essence based on phospholipid-wrapped glabridin nanoemulsion and a preparation method thereof. Background technique [0002] Glabridin is a natural ingredient extracted from Glycyrrhizae glabra, which is widely used in cosmetics. Glabridin has a very ideal whitening effect, and it can inhibit the activities of tyrosinase, dopachrome tautomerase and dihydroxyindole acid oxidase in melanocytes. [0003] Therefore, glabridin has efficient and safe whitening and lightening effects, and its whitening effect is better than arbutin, niacinamide, kojic acid, and VC ethyl ether. It is considered to be the most effective natural whitening ingredient today. By everyone's favor. [0004] Although glabridin has an efficient and safe whitening effect, its insoluble nature limits its wide ap...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/06A61K8/49A61K8/55A61Q19/02
CPCA61K8/498A61K8/553A61K8/922A61K8/068A61Q19/02A61K2800/782A61K2800/413A61K2800/262
Inventor 杨帆周紫燕李沫郭苗周正
Owner 湖北省麦诗特生物科技有限公司
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