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A kind of nano-starch-based microgel microsphere and its preparation method and application

A technology of nano-starch and microspheres, which is applied in chemical instruments and methods, pharmaceutical formulations, and other chemical processes. It can solve the problems of inability to control the particle size of starch microspheres, low preparation efficiency, and complex starch microspheres. Achieve controllable microsphere size, high biocompatibility, and avoid microsphere loss

Active Publication Date: 2022-06-24
广州光驭超材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current method for preparing starch microspheres is relatively complicated and the preparation efficiency is low
Moreover, the preparation of starch microspheres focuses on the preparation of nanometer-sized nanospheres from starch, and the prior art cannot well regulate the particle size of starch microspheres to prepare micron-sized starch microspheres with uniform size.

Method used

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  • A kind of nano-starch-based microgel microsphere and its preparation method and application
  • A kind of nano-starch-based microgel microsphere and its preparation method and application
  • A kind of nano-starch-based microgel microsphere and its preparation method and application

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preparation example Construction

[0032] A preparation method of nano-starch-based microgel microspheres, comprising the following steps:

[0033] Using nano-starch as raw material, adding it into water to prepare nano-starch dispersion, wherein water can be distilled water or deionized water; adding emulsifier to organic solvent to obtain oil phase; adding nano-starch dispersion to oil phase , to obtain a water-in-oil type nano-starch inverse emulsion; and then adding a cross-linking agent and an alkali into the starch inverse emulsion, stirring, and carrying out a cross-linking reaction.

[0034] As a further embodiment, the reacted product is also separated, washed and sieved to obtain nano-starch-based microgel microspheres with a particle size of 75-250 microns.

[0035] The reversed-phase suspension method is to dissolve starch powder in water, and as the water phase, disperse it into an organic solution containing an appropriate amount of emulsifier to form a uniform, stable and transparent microemulsio...

Embodiment 1

[0045] Preparation of cross-linked nano-starch-based microgel microspheres

[0046] Weigh 5g of nano-starch powder, add it to 50g of deionized water, and stir to form a 10% (w / w) nano-starch dispersion; weigh 50ml of n-octane, add 2g of emulsifier Span 80, stir to dissolve, and then use a mechanical The stirring device conducts high-speed stirring at a stirring speed of 800 rpm, and the temperature is raised to 50 ° C during this process; the nano-starch dispersion is poured into the high-speed stirring n-octane while it is still hot, maintained at 50 ° C, and high-speed stirring for 30min; Keep at 50 °C, add 2 ml of 2 mol / L NaOH solution, 2 g of cross-linking agent epichlorohydrin, and stir at a reduced speed, with a stirring speed of 250 rpm, and cross-linking reaction for 0.5 h; then increase the reaction temperature to 95 ° C and continue the reaction for 2 h; The heating is removed, and the solution is layered after standing, and the lower layer is nano-starch-based micro...

Embodiment 2

[0048] Preparation of cross-linked nano-starch-based microgel microspheres

[0049] Weigh 2.5g of nano-starch powder, add it to 50g of deionized water, and stir to form a 5% (w / w) nano-starch dispersion; weigh 50ml of n-octane, add 2g of emulsifier Span 85, stir to dissolve, and then use The mechanical stirring device conducts high-speed stirring at a stirring speed of 1000 rpm, and the temperature rises to 65 °C at the same time during this process; the completely dissolved nanostarch aqueous solution (with high viscosity) is poured into the high-speed stirring n-octane while hot, and maintained at 65 °C, Stir at high speed for 30min; reduce the temperature of the reaction system to 50°C, add 2ml of 2mol / L NaOH solution and 2g of epichlorohydrin, stir at a reduced speed, stir at a speed of 250rpm, and conduct cross-linking reaction for 0.5h; then increase the reaction temperature to 95°C, The reaction was continued for 2 hours; the heating was removed, the solution was layere...

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Abstract

The invention relates to the fields of functional materials and biotechnology, and specifically discloses a nano-starch-based microgel microsphere, a preparation method and application thereof. The preparation method of the nano-starch-based microgel microspheres comprises: taking nano-starch as a raw material and adding water to form a nano-starch dispersion; adding the dispersion into the oil phase, and adding an emulsifier to the oil phase, and stirring to obtain the nano-starch dispersion. phase emulsion; add cross-linking agent and alkaline substance into the inverse emulsion, stir and react to obtain microgel microspheres; wash the microgel microspheres with ethanol, ethanol-water mixture, and water to neutrality in turn to obtain nano Starch-based microgel microspheres. The invention can prepare microgel microspheres with a particle diameter of 75-250 microns, and the microspheres have a porous structure. The preparation time of the present invention is short, the process is simple and efficient, the product has good thermal stability and high mechanical strength, and the microgel microspheres are used as separation microspheres of functional proteins such as antibodies, immobilized microsphere materials for column chromatography, and microgels for medical injections. Microspheres.

Description

technical field [0001] The invention relates to the field of functional materials and biotechnology, in particular to a nano-starch-based microgel microsphere and a preparation method and application thereof. Background technique [0002] Starch is a carbohydrate converted from carbon dioxide and water in the air through photosynthesis. It is the second highest-yielding natural polymer compound with lower yield than cellulose. It has the advantages of high yield, non-toxicity, degradability, and regeneration. Functional microspheres are widely used because they can be used as carriers and have targeting properties. Current research shows that functional microspheres prepared from starch are stable in storage and have good biocompatibility. They not only have some common characteristics of biodegradable microspheres, but also do not end up in the body like protein materials after use. Produce immunogenicity; in addition, raw starch has the advantages of wide source and low p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08J3/24C08L3/02A61K47/36A61K9/06A61K9/16B01J20/24B01J20/28
CPCC08J3/12C08J3/24B01J20/24B01J20/28047B01J20/28004A61K47/36A61K9/06A61K9/0024A61K9/1652C08J2303/02
Inventor 田丰
Owner 广州光驭超材料有限公司
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