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A kind of heparinized PVC material, its preparation method and its application as medical equipment

A PVC material and heparinization technology, applied in the field of medical devices, can solve the problems of residual covalent bond, heparin shedding, lack of adjustment of the amount of heparin grafting, etc., achieving low cost, good anticoagulation effect, and reducing treatment costs Effect

Active Publication Date: 2022-04-29
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Regarding the above preparation method, the inventor believes that the existing preparation method often lacks the way to adjust the amount of heparin grafting, and the medical materials after heparinization have certain risks in use, such as: during the use of the base material bonded with ions, Heparin is easy to fall off under the scouring action of liquid, and covalent bonding usually requires the introduction of chemical cross-linking to cause residues, etc.

Method used

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  • A kind of heparinized PVC material, its preparation method and its application as medical equipment
  • A kind of heparinized PVC material, its preparation method and its application as medical equipment
  • A kind of heparinized PVC material, its preparation method and its application as medical equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Using plasma treatment equipment, ordinary medical PVC materials were modified for 30min under the conditions of voltage amplitude of 4KV, voltage frequency of 40KHz, duty cycle of 40%, modulation frequency of 100Hz and pure helium environment to obtain activated PVC materials with hydroxyl groups on the surface.

[0055] Dissolve 1g heparin sodium in 100ml deionized water to form an aqueous solution of heparin sodium with a mass fraction of 1%, and then adjust the pH of the solution to 1.0 with sulfuric acid. The hydroxyl modified PVC material obtained by plasma treatment in the above steps is immersed in acidic heparin sodium solution, and concentrated sulfuric acid is added as catalyst at the temperature of 60 ℃. After stirring for 6 hours, the base hydroxyl modified heparin anticoagulant catheter ② is obtained, and the unmodified PVC material is ①.

Embodiment 2

[0057] Under the conditions of voltage amplitude of 4KV, voltage frequency of 40KHz, duty cycle of 40%, modulation frequency of 100Hz and mixed environment of helium and 3% oxygen, ordinary medical PVC materials were modified for 30min by plasma treatment equipment to obtain activated PVC materials with carboxyl groups on the surface.

[0058] Dissolve 1g heparin sodium in 100ml deionized water to form an aqueous solution of heparin sodium with a mass fraction of 1%, and then adjust the pH of the solution to 1.0 with sulfuric acid. The carboxyl modified PVC material obtained by plasma treatment in the above steps is immersed in acidic heparin sodium solution, and concentrated sulfuric acid is added as catalyst at the temperature of 60 ℃. After stirring for 6 hours, the base carboxyl modified heparin anticoagulant catheter ③ is obtained, and the unmodified PVC material is ①.

Embodiment 3

[0060] Plasma modification is the same as example 2.

[0061] Dissolve 1g of sodium alginate with viscosity coefficient of 1% and viscosity of 3 ~ 5MPa · s in 100ml deionized water to form a sodium alginate solution with mass fraction of 1%, adjust the pH of the sodium alginate solution to 2 with sulfuric acid, soak the PVC material modified by carboxyl group in the sodium alginate solution in the above steps, add concentrated sulfuric acid as catalyst at 60 ℃ and stir for 6 hours to obtain the PVC material grafted by sodium alginate, It was washed with deionized water and dried in vacuum at room temperature. Put the dried sodium alginate grafted PVC material into the sodium heparin solution with pH of 1.0, add concentrated sulfuric acid as catalyst at the temperature of 60 ℃, stir the reaction for 4h, wash it with deionized water, and then soak it in calcium chloride solution with mass fraction of 2% for crosslinking for 1H. Finally, clean the crosslinked modified catheter with d...

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Abstract

The invention relates to a heparinized PVC material, its preparation method and its application as a medical device. The invention discloses a heparinized PVC material with anticoagulant effect. Its preparation includes the following steps: (1) Using plasma modification equipment to modify the surface of ordinary PVC medical materials, and changing the composition of the ambient gas to change the material surface modification. (2) Prepare a certain concentration of grafting solution, soak the modified PVC material into the modified solution, and control the reaction conditions to covalently graft anticoagulant drugs to the surface of the PVC catheter. (3) After the grafted catheter was washed with deionized water, it was vacuum-dried at room temperature to obtain a heparinized PVC material. The heparinized PVC material has a good anticoagulant effect, can prolong the coagulation time, prevents the formation of thrombus and the blockage of the catheter during use, and also has good biocompatibility, so it has great application in the medical field potential.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a heparinized PVC material, a preparation method thereof and its application as a medical device. Background technology [0002] The disclosure of the information of the background technical part is only for the purpose of increasing the understanding of the overall background of the invention, and is not necessarily deemed to recognize or imply in any form that the information constitutes the prior art that has become well known to those skilled in the art. [0003] After decades of development and improvement, cardiopulmonary bypass technology has become a commonly used adjuvant treatment technology in cardiac surgery. Extracorporeal circulation technology is often used in artificial heart and lung support, emergency rescue, cardiopulmonary resuscitation, organ transplantation and tumor treatment. Especially during the COVID-19, extracorporeal membrane oxygenation (ECMO) dev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L27/06C08L5/10C08L5/04C08L5/08C08J7/12A61L29/04A61L29/08A61L29/16A61L33/10
CPCC08J7/123C08J7/12A61L29/041A61L29/085A61L29/16A61L33/08A61L33/0076A61L2300/232A61L2300/42C08J2327/06C08J2405/10C08J2405/04C08J2405/08C08L27/06C08L5/10C08L5/04
Inventor 满佳张永琪李建勇李剑峰宋鑫忠
Owner SHANDONG UNIV