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Carbon fiber-based electrochemical compound, molecular imprinting sensor as well as preparation method and application of molecular imprinting sensor

An electrochemical and carbon fiber-based technology, applied in the field of carbon fiber-based electrochemical composites, molecular imprinted sensors and their preparation, to achieve good chemical stability, high electron transfer rate, and large aspect ratio

Pending Publication Date: 2022-04-15
JILIN INST OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although theophylline has very unique pharmacological effects, it also causes many emergencies due to its strict safety range

Method used

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  • Carbon fiber-based electrochemical compound, molecular imprinting sensor as well as preparation method and application of molecular imprinting sensor
  • Carbon fiber-based electrochemical compound, molecular imprinting sensor as well as preparation method and application of molecular imprinting sensor
  • Carbon fiber-based electrochemical compound, molecular imprinting sensor as well as preparation method and application of molecular imprinting sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The carbon fibers were ultrasonically cleaned with acetone, secondary water, and absolute ethanol for 25 minutes, and then dried in a vacuum oven at 50°C.

[0050] Take 0.216g CuSO 4 ·5H 2 Dissolve O in 80mL deionized water, stir for 15min; add 0.84mL 25% ammonia water, stir for 15min; then add 0.384g NaOH, stir for 15min until completely dissolved; then add 0.25mL ammonia water and 1.14g hexadecyltrimethyl ammonium chloride, continue to stir for 30 minutes to make it completely dissolved; pour the above solution into a 100mL hydrothermal reaction kettle, then add the treated carbon fiber, and react in an oven at 180°C for 12 hours. After the reaction, the sample is cooled to room temperature Take it out and dry it in an oven at 60°C for use; put the sample obtained above in a muffle furnace and bake it at 450°C for 4 hours, and the product obtained is the electrochemical composite (Cu(OH) 2 / CF).

[0051] Electrochemical composite (Cu(OH) 2 / CF) SEM and TEM images ...

Embodiment 2

[0053] The electrochemical compound prepared in the example was taken, and it was first dispersed by magnetic stirring for 30 minutes, and then dispersed by ultrasonic wave for 20 minutes to obtain a modification solution with a concentration of 0.1M. Take a glassy carbon electrode, polish it, take 0.1 μL of modification solution with a micro-sampler, drop it on the polished glassy carbon electrode, and then dry it under an infrared lamp to obtain a modified electrode.

[0054] Carried out under nitrogen atmosphere. Prepare PBS buffer solution (0.1mol / L) with pH=6; configure 50mL electrolyte solution with 0.5mol / L NaCl, add 3mol / L o-phenylenediamine to the electrolyte solution until completely dissolved, take 0.02g theophylline , sonicated in 20 mL of methanol.

[0055] Take the electrolytic cell and place it on a magnetic stirrer to stir, and quickly pass the N 2 15min; Add 30mL of PBS buffer solution to the electrolytic cell, stir rapidly and pass through the N 2 Remove ...

Embodiment 3

[0059] The molecularly imprinted sensor prepared in Example 2 was used in a three-electrode system to detect different concentrations of theophylline:

[0060] During the detection process, 13 kinds of theophylline solutions with different concentrations were used as the electrolyte, and the glassy carbon electrode modified by molecularly imprinted membrane was used as the working electrode to form a three-electrode system with the calomel electrode and the platinum sheet electrode. The DPV curve of the electrolyte is drawn, and the "peak current value" and the "theophylline concentration value" of the solution are drawn as the ordinate and abscissa respectively to obtain the standard curve of theophylline concentration. Scanning results such as Figure 4 , Figure 5 shown.

[0061] Depend on Figure 4 , Figure 5 It can be seen that the DPV curve and the fitted C-I standard curve of the system under different theophylline contents indicate that when the concentration of t...

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Abstract

The carbon fiber-based electrochemical compound comprises carbon fibers and copper hydroxide crystals, the copper hydroxide crystals grow on the surfaces of the carbon fibers through a hydrothermal method and a roasting method to form a fibrous structure, and the carbon fiber-based electrochemical compound has excellent ion and electron transfer rate and good chemical stability; the invention also provides a molecularly imprinted sensor which is obtained by modifying a glassy carbon electrode with the electrochemical compound and polymerizing a molecularly imprinted membrane on the surface, the molecularly imprinted sensor has relatively strong electron and ion flow transmission property and relatively high targeted recognition on theophylline, electrochemical detection on theophylline is realized through electron flow, and the application prospect is wide. The detection range reaches 4-150 [mu] M, and the detection limit reaches 10 <-7 > M.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a carbon fiber-based electrochemical compound, a molecular imprinted sensor, a preparation method and application thereof. Background technique [0002] With the rapid development of modern electronics and biotechnology, biosensing technology has formed an independent and emerging high-tech field. It involves a variety of technologies in multiple interdisciplinary fields such as biology, chemistry, physics, materials science, medicine, electronic technology, and micro-electromechanical systems. At the same time, the molecular recognition elements in biosensors can specifically combine with biological information, including proteins, organelles, living cells, microorganisms, and tissues, etc., and convert these biological information into analysis signals through transducers, and then pass through the electronic instruments. The secondary amplification and output become the signals ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/48G01N27/30
Inventor 崔萌龙礼坤王晓惠权梓昂邵自强
Owner JILIN INST OF CHEM TECH
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