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Natural extract composite granule suitable for people with hyperuricemia

A technology of natural extracts and composite granules, applied in the field of nutritional functional foods, can solve the problems of lack of hyperuricemia or gout nutritional intervention programs, difficult hyperuricemia control intervention, unstable product efficacy, etc., to delay oxidative loss The effect of increasing the rate of life, improving biological activity, and reducing the incidence of gout

Active Publication Date: 2022-04-22
中科清风康健医学研究(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From 2000 to 2020, patent applications for hyperuricemia or gout have increased by more than 70 times, mostly using natural products or traditional Chinese medicine extracts, such as polyphenols, flavonoids, alkaloids, polysaccharides or oligosaccharides, and even peptide pairs Nutritional intervention for hyperuricemia, polyphenols or flavonoids help to hedge against peroxyl free radicals produced during the formation of uric acid and protect the activity of nitric oxide, but active substances such as polyphenols and flavonoids are reducing, long-term storage Easily oxidized; polyphenols or flavonoids are prone to react with alkaloids, etc., and the chemical reactions between each other during use lead to unstable product efficacy
In addition, in the process from uric acid production to excretion, it is difficult to control or fundamentally intervene in a single link of hyperuricemia, and patent applications for nutritional intervention based on multi-component combinations are limited to some links
Therefore, there is still a lack of nutritional intervention programs for hyperuricemia or gout in the market

Method used

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  • Natural extract composite granule suitable for people with hyperuricemia
  • Natural extract composite granule suitable for people with hyperuricemia

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Embodiment 1

[0032] The raw material is chitosan oligosaccharide particles with polymerization units of 2-5 as the first layer of core material, with an average particle size of 200 μm, and a mixture of celery seed extract, papaya extract and pueraria root extract in a ratio of 1:1:1. After preparation, it is used as the second layer material, wherein the ratio of flavonoids and flavonoid glycosides is 1:7, and the ratio of flavonoids and isoflavones is 2:1. Multivitamin powder is used as the third layer raw material, the ratio of vitamin B6 to vitamin C is 1:10; fish scale oligopeptide powder, the average molecular weight is 1000Da, and every 1000 amino acids contains 32 arginine. Using chitosan oligosaccharide granules as raw material, the aqueous solution of celery seed extract, papaya extract and pueraria root extract mixture, multivitamin aqueous solution and fish scale oligopeptide powder aqueous solution are respectively coated by fluidized bed coating technology to prepare The proc...

Embodiment 2

[0050] The raw material is chitosan oligosaccharide particles with polymerization units of 3-6 as the first layer of core material, with an average particle size of 150 μm, celery seed extract, rattan tea extract and mulberry extract in a ratio of 1:1:1. After compounding, it is used as the second layer material, wherein the ratio of flavonoids and flavonoid glycosides is 2:6, and the ratio of flavonoids and isoflavones is 1.8:1.1. Multivitamin powder is used as the raw material for the third layer, the ratio of vitamin B6 to vitamin C is 1:15; fish skin oligopeptide powder, with an average molecular weight of 900Da, contains 36 arginine per 1000 amino acids. Using chitosan oligosaccharide granules as raw material, the aqueous solution of celery seed extract, papaya extract and pueraria root extract mixture, multivitamin aqueous solution and fish scale oligopeptide powder aqueous solution are respectively coated by fluidized bed coating technology to prepare The process of nat...

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Abstract

The invention discloses a natural extract composite granule suitable for people with hyperuricemia, and the particle size of the composite granule is 50-500 [mu] m; the material has a multi-layer structure and sequentially comprises the following layers from inside to outside: a first layer is an inner core, oligosaccharide particles with the particle size of 30-300 mu m and the density of 0.3-1.5 g / mL; the second layer is a plant extract containing phenols, and the thickness of the second layer is 5-200 microns; the third layer is a vitamin-containing compound, and the thickness of the third layer is 5-200 microns; and the fourth layer is an oligopeptide mixture, and the thickness of the fourth layer is 10-300 [mu] m. According to the composite granule disclosed by the invention, the oligosaccharide can be used as a carrier of the composite granule, the phenol-containing plant extract can eliminate peroxy free radicals generated in a purine oxidation process, the phenol extract is placed on the second layer, so that contact with oxygen can be reduced, and oxidative inactivation possibly caused in a product storage process is reduced. Vitamin substances are arranged on the third layer, so that the oxidative inactivation rate of the vitamin substances is delayed.

Description

technical field [0001] The invention relates to the field of nutritional functional foods, in particular to a natural extract composite granule suitable for people with high uric acid, and more particularly to a natural extract prepared by using Compound granules for uricemia or gout. [0002] technical background [0003] Uric acid is a heterocyclic carbonyl compound whose chemical element composition is C 5 H 4 N 4 O 3 , molecular weight 168.1, scientific name is 2,6,8-trihydroxypurine or 7,9-dihydro-2,6,8(3H)triketo-1H-purine; uric acid molecule is weakly acidic, slightly soluble in water and It is easy to form crystals; uric acid in the human body is the final product of purine metabolism, and mainly exists in the plasma in the form of uric acid anion. [0004] Purines play an important role in energy supply, metabolic regulation and composition of coenzymes in the human body. There are two main sources of purines: one is through dietary purine-containing foods, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/42A61K47/36A61K36/732A61K36/87A61P19/06A23L33/105A23L33/15A23L33/18A23P20/20A61K31/4415A61K31/375
CPCA61K9/5052A61K9/5036A61K36/23A61K36/732A61K36/488A61K36/87A61K36/605A61K31/4415A61K31/375A23L33/105A23L33/15A23L33/18A23P20/20A23V2002/00A61K2300/00A23V2200/30A23V2250/28A23V2250/21A23V2250/2116A23V2250/7052A23V2250/708A23V2250/55Y02A50/30
Inventor 张天阳罗嫚
Owner 中科清风康健医学研究(北京)有限公司
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