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First-aid double-bionic gel hemostatic composite material and preparation method thereof

A composite material and gel technology, which is applied in applications, surgical adhesives, medical science, etc., can solve the problems of cumbersome preparation steps, shedding, and unsatisfactory wet tissue adhesion, and achieve strong wet tissue adhesion and promote Effect on tissue healing, rapid hemostasis efficiency

Active Publication Date: 2022-04-26
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic material prepared by this technical scheme has good biocompatibility, safety and non-toxicity; it can rapidly promote blood coagulation, and can complete rapid hemostasis within a certain application range, but it has no adhesion to wet tissues and is not suitable for large arterial bleeding and visceral bleeding
And its preparation steps are also comparatively loaded down with trivial details, not suitable for mass production
[0006] patent CN 112220962A discloses a kind of n-butyl cyanoacrylate and n-octyl cyanoacrylate as mixed medical glue base, and by using CO 2Supercritical fluid carries selected ionic liquid to swell and modify the hemostatic material carboxymethyl chitosan, which effectively improves the hemostatic performance of carboxymethyl chitosan, making the whole medical adhesive The hemostatic performance of the material has been greatly improved to achieve rapid hemostasis. However, the wet tissue adhesion of this hemostatic adhesive material is not ideal, and it will fall off under the washing of a large amount of blood. It cannot achieve the control of explosive bleeding, nor can it satisfy long-term hemostasis. needs

Method used

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  • First-aid double-bionic gel hemostatic composite material and preparation method thereof
  • First-aid double-bionic gel hemostatic composite material and preparation method thereof
  • First-aid double-bionic gel hemostatic composite material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] A preparation method for first-aid double-prevention gel hemostatic composite material, comprising the following steps:

[0037] (1) Dissolve 75.0 mg of phenolic hydroxy chitosan in 9 mL of PBS buffer (0.1mol / L, pH=6.8) to obtain solution A.

[0038] (2) Dissolve 3.0 g of tannic acid in 10.0 mL of distilled water to obtain solution B.

[0039] (3) Dissolve 3.5 g of sodium alginate in 10 mL of distilled water at 45 °C for 2 h to obtain solution C.

[0040] (4) Dissolve 10.0 g silkworm cocoons in 4.0 L 0.02 mol / L Na 2 CO 3 Boil the solution for 20 minutes to remove sericin. Subsequently, the degummed cocoons were fully washed with deionized water, and dried at 60° C. for 3 hours to obtain degummed silk fibroin fibers. 13.5 g of degummed silk fibroin fibers were dissolved in 50.0 mL of 9.3 mol / L lithium bromide solution at 60°C for 4 h. The dissolved solution was put into a dialysis bag with a molecular weight cut off of 3500, and dialyzed with deionized water for 48 ho...

Embodiment 2

[0043] A preparation method for first-aid double-prevention gel hemostatic composite material, comprising the following steps:

[0044] (1) Dissolve 75.0 mg of phenolic hydroxy chitosan in 9 mL of PBS buffer (0.1mol / L, pH=6.8) to obtain solution A.

[0045] (2) Dissolve 3.0 g of tannic acid in 10.0 mL of distilled water to obtain solution B.

[0046] (3) Dissolve 3.5 g of sodium alginate in 10 mL of distilled water at 45 °C for 2 h to obtain solution C.

[0047] (4) Dissolve 10.0 g silkworm cocoons in 4.0 L 0.02 mol / L Na 2 CO 3 Boil the solution for 20 minutes to remove sericin. Subsequently, the degummed cocoons were fully washed with deionized water, and dried at 60° C. for 3 hours to obtain degummed silk fibroin fibers. 13.5 g of degummed silk fibroin fibers were dissolved in 50.0 mL of 9.3 mol / L lithium bromide solution at 60°C for 4 h. The dissolved solution was put into a dialysis bag with a molecular weight cut off of 3500, and dialyzed with deionized water for 48 ...

Embodiment 3

[0050] A preparation method for first-aid double-prevention gel hemostatic composite material, comprising the following steps:

[0051] (1) Dissolve 75.0 mg of phenolic hydroxy chitosan in 9 mL of PBS buffer (0.1mol / L, pH=6.8) to obtain solution A.

[0052] (2) Dissolve 3.0 g of tannic acid in 10.0 mL of distilled water to obtain solution B.

[0053] (3) Dissolve 3.5 g of sodium alginate in 10 mL of distilled water at 45°C for 2 h, then add 20 μL of 1000 ppm nano-silver solution (nano-silver particle size is 10-15 nm), and sonicate for 30 min (sonication temperature 25°C, ultrasonic treatment frequency 40KHZ, ultrasonic treatment power 500W), to obtain solution C.

[0054] (4) Dissolve 10.0 g silkworm cocoons in 4.0 L 0.02 mol / L Na 2 CO 3 Boil in the solution for 20 min to remove sericin. Subsequently, the degummed cocoons were fully washed with deionized water, and dried at 60° C. for 3 hours to obtain degummed silk fibroin fibers. 13.5 g of degummed silk fibroin fibers ...

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Abstract

The invention discloses a first-aid double-bionic gel hemostatic material and a preparation method thereof. The double-bionic gel hemostatic material for emergency treatment is inspired by an underwater adhesion mechanism of marine mussels and barnacles, and contains bionic marine mussel biological substances and bionic marine barnacles biological substances as well as bioactive molecules. The prepared double-bionic gel hemostatic material for first aid is high in bonding speed in a wet environment, has the advantages of being high in hemostatic efficiency, rapid in tissue repair, high in antibacterial activity, safe, non-toxic and good in biocompatibility, can be extruded out through an integrated device, is convenient to operate, is expected to replace a traditional hemostatic mode, and has a wide application prospect. The method becomes a new development direction of hemostatic materials in the future.

Description

technical field [0001] The invention belongs to the field of biological material preparation and biomedical application, and in particular relates to a double bionic gel hemostatic material for first aid and a preparation method thereof. Background technique [0002] The occurrence of organ trauma, especially rupture of the aorta and obstructive bleeding in the heart, can easily lead to massive hemorrhage in the human body. According to reports, more than 30% of traumatic deaths worldwide are caused by excessive blood loss. At present, the hemostasis methods adopted clinically include gauze compression to stop bleeding, surgical suture to stop bleeding, and electrocoagulation to stop bleeding. However, these methods have low hemostatic efficiency, high bleeding volume, and may even cause secondary damage to surrounding tissues. At present, with the continuous development of material science, many new materials are used for hemostasis, such as chitosan, zeolite, collagen, a...

Claims

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Application Information

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IPC IPC(8): A61L24/00
CPCA61L24/0094A61L24/0015A61L24/0005A61L24/001A61L2400/04A61L2300/404
Inventor 张进李飞翰潘高星杨黄浩
Owner FUZHOU UNIV
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