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Apricot kernel oil scald ointment as well as preparation method and application thereof

A technology of almond oil and scald ointment, which is applied in the field of medicine, can solve the problems of not being able to improve the microenvironment of injured tissues and the balance of collagen metabolism, and achieve the effects of improving the metabolic microenvironment, facilitating industrial production, and inhibiting excessive proliferation

Pending Publication Date: 2022-05-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used drugs include anti-infection drugs and anti-corrosion and muscle-removing drugs, such as antibiotics, some blood circulation promoting and stasis-removing and nourishing Chinese medicines, etc., which cannot change the metabolic balance of collagen, so even if inflammation is controlled and hyperplasia is promoted, scars may not be eliminated
[0003] Almond oil has the effect of protecting the skin. CN104288828A and CN105169463A disclose a dressing containing almond oil, which can be used to treat burns, but simple oil can only isolate the air to prevent wound infection, and cannot improve the microenvironment of the injured tissue from the nutritional metabolism of the subcutaneous tissue

Method used

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  • Apricot kernel oil scald ointment as well as preparation method and application thereof
  • Apricot kernel oil scald ointment as well as preparation method and application thereof
  • Apricot kernel oil scald ointment as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) 1 kg of almonds was crushed through a 10-mesh sieve, added with 10 g of immobilized neutral protease and 8 kg of 40°C pH5 acetate buffer for extraction for 1 hour, then centrifuged at 3000 rpm for 60 minutes, and the supernatant was collected as sweet almond oil, which was extracted with a molecular weight cut-off of 5 kDa membrane filtration, and the filtrate was freeze-dried for 24 hours to obtain 165 g of almond polypeptide;

[0039] (2) 1 kg of apricot pulp was added with 5 g of immobilized fructosidase and 8 kg of pH5 acetate buffer solution, reacted at 40° C. for 1 h and then filtered, and the filtrate was freeze-dried for 24 h to obtain 87 g of almond oligosaccharides;

[0040] (3) Add 5g lipase to 100g almond oil and react with 800g 40°C pH5 acetate buffer for 1 hour, then add 500g ethyl acetate and 50g apricot oligosaccharides, continue the reaction for 1 hour, then let it stand for 8 hours, and the upper layer is heated at 50°C, 0.01 MPa was concentrated a...

Embodiment 2

[0043] (1) 1 kg of almonds was crushed through a 30-mesh sieve, added with 100 g of immobilized alkaline protease and 30 kg of 60°C pH9 phosphate buffer for extraction for 3 hours, centrifuged at 5000 rpm for 30 minutes, and the upper layer was collected as sweet almond oil, and the lower layer was intercepted Membrane filtration with a molecular weight of 20kDa, and the filtrate was freeze-dried for 48 hours to obtain 235g of almond polypeptide;

[0044] (2) Add 50 g of immobilized lactase and 30-fold pH 9 phosphate buffer to 1 kg of apricot pulp, react at 60° C. for 3 h, filter, freeze-dry the filtrate for 48 h, and obtain 117 g of almond oligosaccharides;

[0045](3) Add 10g lipase to 100g almond oil and react with 3kg 60℃pH9 phosphate buffer for 3h, then add 1kg petroleum ether and 150g almond oligosaccharides, continue to react for 3h, then let it stand for 24h, and the supernatant is heated at 70℃, 0.1MPa Concentrate and dry for 8 hours to obtain 120 g of almond oil and ...

Embodiment 3

[0048] (1) 1 kg of almonds was crushed through a 20-mesh sieve, added 50 g of immobilized papain and 15 kg of 60°C pH6 Tris-HCl buffer solution for extraction for 2 hours, centrifuged at 4000 rpm for 40 minutes, and the upper layer was collected as sweet almond oil, and the lower layer was used Membrane filtration with a molecular weight cut-off of 10kDa, and the filtrate was freeze-dried for 36 hours to obtain 215g of almond polypeptide;

[0049] (2) Add 25 g of immobilized dextranase and 20 times of pH6 Tris-HCl buffer solution to 1 kg of apricot pulp, react at 60° C. for 2 h and filter, freeze-dry the filtrate for 36 h to obtain 104 g of almond oligosaccharides;

[0050] (3) Add 7g lipase and 1.5kg 60°C pH6 Tris-HCl buffer to 100g almond oil and react for 2h, then add 700g cyclohexane and 100g almond oligosaccharides, continue to react for 2h, let it stand for 16h, and the supernatant is passed through 60 °C, concentrated and dried at 0.05 MPa for 5 hours to obtain 132 g of...

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Abstract

The invention belongs to the technical field of scald ointment, and discloses almond oil scald ointment as well as a preparation method and application thereof. The method comprises the following steps: 1) reacting almonds with protease, and centrifuging to obtain supernatant which is sweet almond oil; filtering and drying the subnatant to obtain the almond polypeptide; (2) reacting the apricot pulp with polysaccharide hydrolase to obtain apricot oligosaccharide; (3) reacting the almond oil with lipase, adding a water-insoluble organic solvent and apricot oligosaccharide, and continuously reacting to obtain an almond oil and apricot oligosaccharide conjugate; (4) respectively preparing the almond polypeptide and the almond oil and oligosaccharide conjugate into dispersion liquid; under the stirring condition, the almond polypeptide dispersion liquid and the almond oil and oligosaccharide conjugate dispersion liquid are mixed and filtered through a filter membrane, and the almond oil scald ointment is obtained. The scald ointment disclosed by the invention can prevent infection and regulate metabolism balance of fat, sugar and protein of subcutaneous tissues, so that formation of scars is reduced while wound healing is promoted. The scald ointment is used for preparing medicines for preventing and treating scalds and repairing scars.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an almond oil scald ointment and a preparation method and application thereof. Background technique [0002] Burns are tissue injuries caused by flames, high-temperature steam or liquids, mainly the skin or mucous membranes, and can seriously injure the subcutaneous tissue. Can cause local pain, skin redness, blisters, damage and so on. Wound treatment and timely drug application can effectively reduce the continuous damage and accelerate recovery, but improper drug use not only delays recovery, but also produces scars. Scars are due to changes in the local microenvironment during the wound healing process, which disrupts the balance of collagen synthesis and decomposition functions, resulting in abnormal accumulation and arrangement of scar collagen fibers. Commonly used drugs include anti-infection drugs and saprophytic drugs, such as antibiotics, some activating blood cir...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K9/06A61P17/02C12P21/06C07K1/34C12P19/14C12P19/00A61K36/736A61K31/702
CPCA61K38/011A61K36/736A61K31/702A61K9/06A61P17/02C12P21/06C07K1/34C12P19/14C12P19/00A61K2300/00
Inventor 叶勇唐小月周春卡吴彩娥温靖
Owner SOUTH CHINA UNIV OF TECH
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