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Degradable composite film for heart occluder as well as preparation method and application of degradable composite film

A composite film and reaction technology, which is applied in the fields of medical formulation, surgery, drug delivery, etc., can solve the problems that are not conducive to occluder implantation and morphology observation, poor X-ray visualization of degradable flow-blocking membrane, and hindering the formation of normal new tissue, etc. Problems, to achieve the effect of facilitating adhesion and growth, improving X-ray imaging ability, and improving anticoagulant performance

Active Publication Date: 2022-06-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current degradable choke membrane still has the following problems: 1. Degradation of the degradable choke membrane in the body will cause oxidative stress, induce local inflammation, and hinder the formation of normal new tissue
2. The degradable choke membrane has thrombogenicity, and it is easy to induce thrombus after implantation into the blood
3. The degradable choke membrane has poor X-ray imaging, which is not conducive to observing the implantation and morphology of the occluder

Method used

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  • Degradable composite film for heart occluder as well as preparation method and application of degradable composite film
  • Degradable composite film for heart occluder as well as preparation method and application of degradable composite film
  • Degradable composite film for heart occluder as well as preparation method and application of degradable composite film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1. Preparation of gelatin derivatives (dopamine / double bond modified gelatin)

[0055] 5 g of gelatin (bloom value of 300 g) was dissolved in 100 ml of deionized water and heated to 60° C., and then 1 ml (1.035 g) of methacrylic anhydride was added to react at 60° C. for 1 h. The resulting mixed solution was dialyzed with a dialysis bag with a molecular weight cut-off of 10 KDa for 3 days and freeze-dried to obtain 4.3 g of a double bond-modified gelatin product. Dissolve 2g double bond modified gelatin in 100ml MES buffer (pH=5.5), then add 10mmol of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC), 10mmol of N-hydroxysuccinimide (NHS) and 10 mmol of dopamine hydrochloride, the solution was heated to 40 °C for 8 h. The mixed solution was dialyzed with a dialysis bag with a molecular weight cut-off of 10 KDa for 3 days and freeze-dried to obtain 3.5 g of a dopamine / double bond modified gelatin product.

Embodiment 2

[0056] Example 2. Preparation of gelatin derivative-modified ceria particles

[0057] Dissolve 2 g of dopamine / double bond modified gelatin in 100 ml of deionized water, add 1.737 g of cerium nitrate hexahydrate, stir at room temperature for 1 h, then add concentrated ammonia water to adjust the pH to 8, and stir at room temperature for 24 h to obtain a gelatin derivative-modified dioxide Cerium particles, such as figure 1 As shown, the particle size is between 10-20 nm.

Embodiment 3

[0058] Example 3. Preparation of double bond modified polylactic acid film (PLA film)

[0059] The polylactic acid film was soaked in an isopropanol solution of polyethyleneimine (0.1 g / mL), heated at 50 degrees Celsius for 10 minutes, then ultrasonically cleaned with deionized water, and the cleaned polylactic acid film was soaked in a newly configured In a 0.5 wt% methacrylic anhydride aqueous solution, sodium hydroxide solution was used to adjust the pH of the solution to 8.0, after 3 hours of reaction at room temperature, ultrasonic cleaning was performed with deionized water, and then ultrasonic cleaning with ethanol was used to obtain a double bond modified polylactic acid membrane.

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Abstract

The invention relates to a degradable composite film as well as a preparation method and application thereof. The degradable composite membrane comprises a high polymer material membrane, the upper surface and the lower surface of the high polymer material membrane are covered with hydrogel membranes respectively, and the high polymer material membrane and the hydrogel membranes are connected through covalent bonds; a high polymer material in the high polymer material film is selected from polylactic acid, polyglycolic acid, a polylactic acid-glycolic acid copolymer, polyhydroxyalkanoate, poly (p-dioxanone), polycaprolactone and a polyurethane film; the hydrogel film contains a zwitterionic polymer, the cross-linking agent is gelatin derivative modified metal oxide nanoparticles, and the metal oxide nanoparticles and the gelatin derivative are connected through coordinate bonds or ionic bonds; the gelatin derivative contains a catechol group and an unsaturated double-bond group at the same time. The composite membrane is good in anticoagulation performance and X-ray developing capacity, can promote adhesion and growth of endothelial cells, and is beneficial to generation of normal new tissues on the surface of the membrane.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a degradable composite membrane for a cardiac occluder and a preparation method and application thereof. Background technique [0002] Atrial septal defect, ventricular septal defect, patent ductus arteriosus, patent foramen ovale are several of the most common congenital heart diseases, which lead to abnormal blood flow path in the patient's heart, increase the heart load, and cause heart failure in severe cases. even death. Atrial fibrillation, referred to as atrial fibrillation, is the most common cardiac arrhythmia in clinical practice, which causes blood in the atrium to be unable to be pumped normally, and blood stasis will form thrombus. part produced. In order to prevent the abnormal flow of blood flow in the above parts, interventional cardiac occluder is the most effective and safe clinical treatment method. Due to the significant differences in the geom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00
CPCA61L31/06A61L31/045A61L31/028A61L31/148A61L31/145A61L31/18A61L31/16A61B17/0057A61L2300/102A61L2300/41A61L2400/12A61B2017/00004A61B2017/00893
Inventor 王云兵郭高阳杨凡杨立
Owner SICHUAN UNIV
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