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Polyurethane elastomer and application thereof

A technology of polyurethane elastomer and polyurethane prepolymer, which is applied in the direction of prosthesis, drug delivery, tissue regeneration, etc., can solve the problem of affecting the light transmittance and refractive index of the intraocular lens, unable to cooperate with the physiological refraction adjustment function of the eye, and not satisfying the actual situation Use requirements and other issues to achieve effects that are not conducive to cell proliferation and protein adhesion, non-toxic and immunogenic, and good optical properties

Pending Publication Date: 2022-06-24
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1992, Hettlich et al. injected photopolymerized acrylate copolymer into the lens capsule, but its disadvantages are that it lacks elasticity after agglutination and heat generation damages surrounding tissues during agglutination.
The invention patent with the authorization number CN 106632833 B discloses an intraocular lens material that can be injected into the lens capsule. This material has the advantages of low physical and mechanical strength and can reduce the proliferation of epithelial cells on the surface of the material, but because of its It is a hydrogel material with water absorption, so it is easy to absorb and retain metabolic substances and proteins in the aqueous humor, causing the material to be turbid, which seriously affects the light transmittance and refractive index of the intraocular lens, and does not meet the actual use needs
In addition, the invention patent with the authorized notification number CN 108578768 B discloses a high-strength injectable temperature-sensitive intraocular lens material, which can slowly release anti-inflammatory drugs and treat inflammatory complications of ophthalmic surgery through drugs, but Its mechanical strength is high, and it cannot cooperate with the intraocular lens capsule to complete the physiological refractive adjustment function of the eye under the control of the ciliary muscle, let alone avoid other postoperative complications, such as glaucoma and post-cataract

Method used

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  • Polyurethane elastomer and application thereof
  • Polyurethane elastomer and application thereof
  • Polyurethane elastomer and application thereof

Examples

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preparation example Construction

[0029] The application also provides a method for preparing a polyurethane elastomer, which specifically includes the following steps:

[0030] The polyester diol and isophorone diisocyanate are reacted under a catalyst to stabilize the NCO value to obtain a polyurethane prepolymer;

[0031] The polyurethane prepolymer is reacted with the small molecule chain extender and the end-capping agent under the catalyst, and the polyurethane elastomer is obtained after curing.

[0032] In the above preparation process, the application first reacts polyester diol and isophorone diisocyanate under a catalyst to a stable NCO value to obtain a polyurethane prepolymer; in this process, the catalyst is specifically selected from bismuth isooctoate, Potassium isooctanoate, stannous octoate, dibutyltin dilaurate, 1,8-diazabicyclo[5.4.0]undec-7-ene, 1,4-dimethylpiperazine, triethylenedicarbonate One or more of amine, bis(dimethylaminoethyl) ether, dimethylcyclohexylamine and pentamethyldiethy...

Embodiment 1

[0037] Under nitrogen protection, add 10.57g of isophorone diisocyanate to 50.00g of anhydrous poly(1,6-hexanediol neopentyl adipate diol) diol (molecular weight 1500), stir evenly, then 0.10g of dibutyltin dilaurate was added to it, and the reaction was stirred at 75°C until the NCO value was stable to obtain a polyurethane prepolymer; 50.00g of the polyurethane prepolymer was taken out, defoamed at 80°C for 30min, and then 0.31g of 2-ethyl-1,3-hexanediol, 4.25g of 3-aminopropyltriethoxysilane and 0.05g of dibutyltin dilaurate were mechanically stirred at 1000rpm for 10min. After curing Obtained transparent polyurethane elastomer material (such as figure 1 ).

Embodiment 2

[0039] Under nitrogen protection, add 10.57g of isophorone diisocyanate to 50.00g of anhydrous poly(1,6-hexanediol neopentyl adipate diol) diol (molecular weight 1500), stir evenly, then 0.20 g of dibutyltin dilaurate was added thereto, and the reaction was stirred at 75° C. until the NCO value was stable to obtain a polyurethane prepolymer. Take out 50.00g of polyurethane prepolymer, defoaming under vacuum at 70°C for 45min, then add 3.65g of 2-ethyl-1,3-hexanediol to it, stir mechanically, rotate speed at 1200rpm for 10min, vacuum at 40°C The transparent polyurethane elastomer material was obtained by curing after defoaming for 6 hours.

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Abstract

The invention provides a polyurethane elastomer. The polyurethane elastomer is prepared from polyester diol, isophorone diisocyanate, a small molecule chain extender and an end-capping reagent. The polyurethane elastomer provided by the invention has the advantages of no toxicity, low elastic modulus, no water absorption, low cell proliferation, good optical performance and no material leakage after being injected into a lens capsule. Furthermore, the polyurethane elastomer provided by the invention can be directly implanted into a lens capsule through an injection means, an operative incision is small, material leakage does not occur, and the polyurethane elastomer can be matched with the lens capsule to simulate a physiological regulation function of a human eye lens while the implantation requirement of the artificial lens is met, so that complications of ophthalmic operations are effectively reduced.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a polyurethane elastomer and its application. Background technique [0002] The eye is an organ that can perceive light, and its refraction and adjustment are achieved by the cornea, aqueous humor, lens and vitreous. The lens is a biconvex lenticular transparent tissue fixed between the iris and the vitreous by the suspensory ligament, including the lens capsule, cortex and nucleus. The nutrition of the lens comes from the aqueous humor. When encountering aqueous humor metabolic imbalance, damage to the lens capsule, aging, genetics, trauma, poisoning and radiation, the lens becomes cloudy due to protein denaturation, turning the originally transparent tissue into opaque milky white. , which in turn leads to the inability of light to be projected onto the retina, affecting the ability to see objects, the so-called "cataract". Cataracts mostly occur in people over t...

Claims

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Application Information

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IPC IPC(8): C08G18/75C08G18/66C08G18/44C08G18/42C08G18/28C08G18/12C08G18/10A61L27/50A61L27/18
CPCC08G18/755C08G18/4238C08G18/4277C08G18/44C08G18/10C08G18/289C08G18/4202C08G18/12C08G18/2885C08G18/6651C08G18/664C08G18/6655A61L27/18A61L27/50A61L2400/06A61L2430/16C08L75/04C08G18/3206C08G18/2805C08G18/3234C08G18/3281C08G18/3228
Inventor 李金歌杨小牛李洋
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI