Method for preparing magnetic nano microparticles with biological compatibility

A biocompatible, magnetic nanotechnology, applied in magnetic materials, nanotechnology, nanotechnology, etc., to achieve the effects of good water solubility and dispersibility, adjustable crystal structure, and outstanding advantages
CN1461020AInactive Publication Date: 2003-12-10苏州欣影生物医药技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
苏州欣影生物医药技术有限公司
Publication Date
2003-12-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The preparation method of magnetic nano particle with bio-compatibility includes the following steps: heating and decomposing metal organic iron compound in high boiling point polar solvent in the presence of bio-compatibility molecule, precipitating and separating so as to obtain said magnetic nano particles with bio-compatibility. By adopting bio-compatibity molecules containing double-functional group (for example double-functional group polyglycol and its derivative, etc.) to make modification the magnetic nano particles whose surface has different functional groups can be obtained. By adopting different iron materials the nano particles with different types of Fe, gamma-Fe2O3 and Fe3O4 can be obtained.
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Description

Technical field:

[0001] The present invention relates to a method for preparing biocompatible magnetic nanoparticles. Background technique:

[0002] Iron and its oxide magnetic nanoparticles are widely used in various fields of biomedicine, such as magnetic resonance imaging enhancement (MRI), cell labeling and separation, DNA separation, tumor diagnosis and treatment, targeted drug carriers, etc. However, the particle size, magnetic responsiveness and biocompatibility have always restricted the application of magnetic nanoparticles in many fields mentioned above. Co-precipitation is a traditional method for preparing magnetic nanoparticles, but the size distribution of the obtained particles is wide, and the size and stability of the particles depend strongly on the pH value of the system. In order to overcome this shortcoming, many scholars adopt the micelle (reverse micelle) method to prepare magnetic nanoparticles. Although the size of the particles obtained by this met...

Claims

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