Method for preparing magnetic nano microparticles with biological compatibility

A biocompatible, magnetic nanotechnology, applied in magnetic materials, nanotechnology, nanotechnology, etc., to achieve the effects of good water solubility and dispersibility, adjustable crystal structure, and outstanding advantages

Inactive Publication Date: 2003-12-10
苏州欣影生物医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although polyethylene glycol (and its derivatives) and amino acids are widely used in biomedicine, their use in the modification of magnetic nanoparticles is rarely reported.

Method used

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  • Method for preparing magnetic nano microparticles with biological compatibility
  • Method for preparing magnetic nano microparticles with biological compatibility
  • Method for preparing magnetic nano microparticles with biological compatibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 0.32g of iron octanoate and 0.72g of dihydroxypolyethylene glycol (HO-PEG-OH, M=4000) and dissolve in 50ml of α-pyrrolidone, heat and reflux at 240°C for 40 minutes, cool to room temperature, and use a large amount of methanol The solution obtained from the precipitation reaction can be centrifuged and dried to obtain a dry powder of magnetic nanoparticles that is easy to store and transport. attached figure 1 (A) is a transmission electron microscope (TEM) photo of the obtained microparticles. It can be seen from the figure that the average diameter of the microparticles is 4 nm, and the particle size distribution is narrow. attached figure 2 (A) is an X-ray diffraction (XRD) pattern of the obtained particles, from which it can be seen that the obtained particles are γ-Fe 2 o 3 , but the crystallinity of the particles is low.

Embodiment 2

[0021] Weigh 0.30g of ferric oxalate and 0.42g of arginine and dissolve in 80ml of N-methyl-2-pyrrolidone, heat and reflux at 210°C for 50 minutes, and the rest of the operations are the same as in Example 1. attached figure 1 (B) is a transmission electron microscope (TEM) photo of the obtained microparticles. It can be seen from the figure that the average diameter of the microparticles is 6 nm, and the particle size distribution is narrow. attached figure 2 (B) is the X-ray diffraction (XRD) pattern of the obtained particles, from which it can be seen that the obtained particles are γ-Fe 2 o 3 , but the crystallinity of the particles is low.

Embodiment 3

[0023] Weigh 0.32g of iron acetylacetonate and 0.32g of aspartic acid and dissolve in 90ml of α-pyrrolidone, heat and reflux at 230°C for 30 minutes, cool to room temperature and precipitate with a large amount of acetone, and the rest of the operations are the same as in Example 1. attached figure 1 (C) is a transmission electron microscope (TEM) photo of the obtained microparticles. It can be seen from the figure that the average diameter of the microparticles is 8nm, and the particle size distribution is narrow. attached figure 2 (C) is an X-ray diffraction (XRD) figure of the obtained particles, from which it can be seen that the obtained particles are Fe 3 o 4 , the crystallinity of the particles is high.

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Abstract

The preparation method of magnetic nano particle with bio-compatibility includes the following steps: heating and decomposing metal organic iron compound in high boiling point polar solvent in the presence of bio-compatibility molecule, precipitating and separating so as to obtain said magnetic nano particles with bio-compatibility. By adopting bio-compatibity molecules containing double-functional group (for example double-functional group polyglycol and its derivative, etc.) to make modification the magnetic nano particles whose surface has different functional groups can be obtained. By adopting different iron materials the nano particles with different types of Fe, gamma-Fe2O3 and Fe3O4 can be obtained.

Description

Technical field: [0001] The present invention relates to a method for preparing biocompatible magnetic nanoparticles. Background technique: [0002] Iron and its oxide magnetic nanoparticles are widely used in various fields of biomedicine, such as magnetic resonance imaging enhancement (MRI), cell labeling and separation, DNA separation, tumor diagnosis and treatment, targeted drug carriers, etc. However, the particle size, magnetic responsiveness and biocompatibility have always restricted the application of magnetic nanoparticles in many fields mentioned above. Co-precipitation is a traditional method for preparing magnetic nanoparticles, but the size distribution of the obtained particles is wide, and the size and stability of the particles depend strongly on the pH value of the system. In order to overcome this shortcoming, many scholars adopt the micelle (reverse micelle) method to prepare magnetic nanoparticles. Although the size of the particles obtained by this met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51H01F1/00H01F1/34
CPCH01F1/344H01F1/0045A61K9/51B82Y25/00H01F1/0054
Inventor 高明远李桢
Owner 苏州欣影生物医药技术有限公司
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