Biodegradable nanofiber nonwoven fabric capable of preventing postoperative adhesion and preparation thereof

Abstract

The invention provides a biodegradable textile fiber adhesive-bonded fabric to prevent adhesion after the operation and its preparing method, which belongs to the domain of medical article, and relates to the preparation of a nanometre-sized fiber adhesive-bonded fabric and the application as the anti-block film after the operation. The said adhesive-bonded fabric is prepared by adopting electrostatic spinning method, which includes preparing spin dope, dissolving the aliphatic polyester in the flux and mixing intimately to prepare the aliphatic polyester spin dope. The used flux of the spin dope can be one or compound system of two of carrene, chloroform, acetone, acetylene tetrachloride,acetic acid dimethylamide. Secondarily on the electrostatic spinning machine, by filling spin dope, electrostatic spinning and collecting superfine fibre, the aliphatic polyester superfine fibre is prepared, which carries out the adhesive-bonded fabric of electronic spinning nanometre-grade fiber and which can be used as blocking agent after the operation by the decontamination and biocidal treatment. The cloth has good flexibility and toughness, which can overcome the defect of anti-block film reported in the past. Because the degradable materials are selected, the adhesive-bonded fabric begins to degrade after about one month and completely degrade finally, which comes up to the anti-block function.

Description

Technical field: [0001] The invention "a biodegradable nanofiber nonwoven fabric for preventing postoperative adhesion and its preparation" belongs to the field of medical supplies, and relates to the preparation of a nanofiber nonwoven fabric and its application as a postoperative anti-adhesion film. Background technique: [0002] Postoperative adhesion is one of the important issues that have not been solved at home and abroad since the history of surgery. There are nearly ten million cases of various types of surgery in the country every year, and almost all of them involve anti-adhesion between tissues and local anti-inflammation. It can not only cause serious complications, such as: adhesive intestinal obstruction after abdominal and pelvic surgery, postoperative epilepsy after craniotomy, secondary meridian damage after thyroid surgery, etc. The most important reason for the significant increase in complications at the time, such as intestinal duct damage, Weitong ner...

AI Technical Summary

Problems solved by technology

Streptokinase is injected from the microporous tubules retained in the abdominal cavity in order to dissolve fibrin, but because only a small amount can be injected, the tube holes can be blocked, tubule translocation and many other factors, the curative effect is not significant

At present, bioabsorbable medical films are used as physical barriers to prevent postoperative adhesions. There are polylactic acid films, hyaluronic acid films, chitosan films and oxidized cellulose films. Commercially available polylactic acid films are polylactic acid and ethanol. The film of acid copolymer or polylactic acid homopolymer is brittle, flexible, and poor in stretchability, and it is difficult to fit well with the tissue. Even adding plasticizers cannot fully meet the clinical requirements.

The degradation time of hyaluronic acid film, chitosan film and oxidized cellulose film is too short to maintain the physical barrier function within the required time, so that the anti-adhesion function cannot be well completed

Images