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Degradable chemically-crosslinked aquagel and its preparation method

A chemical cross-linking and hydrogel technology, applied in the field of temperature-sensitive chemical cross-linking hydrogel and its preparation, can solve the problems of loss of gel properties, easy dissolving of ionic medium, and lack of strength of the gel, and achieves a beneficial effect. The effect of large-scale industrial production, mature reaction technology and simple post-processing

Inactive Publication Date: 2007-07-11
ZHEJIANG TRIPLE WIN MEDICAL APPLIANCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the calcium ions in this kind of hydrogel are easy to ion exchange with the ions in the surrounding medium, and this process is difficult to control and cannot be avoided, so it is easy to dissolve in the ionic medium and lose the gel properties.
Agarose gel is a kind of natural polysaccharide extracted from seaweed, which is thermoreversible, and the gel dissolves under heating conditions, but this type of gel lacks sufficient strength, and the adhesion to cells and surrounding tissues is slightly Difference

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Add 20g of polyethylene glycol (1500) into a 250ml three-necked flask, then add 34.2g of DL-lactide and 6.45g of glycolide, heat it under vacuum to make it melt completely, add 50mg of stannous isooctanoate, and heat up the oil bath Reaction at 150°C for 24 hours. After the reaction is completed, the initial product is dissolved in dichloromethane solution, and ether is precipitated to obtain a BAB type block copolymer (A and B respectively represent a hydrophilic block and a degradable hydrophobic block), and the yield is about 85%. Then, under an argon atmosphere, 10 g of block copolymer was added to a 250 ml three-necked flask, and after 100 ml of dichloromethane solution was dissolved, anhydrous triethylamine equivalent to acryloyl chloride was added and stirred evenly; Add 30ml of the mixed solution of acryloyl chloride (the molar ratio of the same block copolymer is 4 / 1) and dichloromethane dropwise into the funnel, and the dropwise addition is completed within a ...

Embodiment 2

[0045] Under an argon atmosphere, 20 g of functionalized polyethylene glycol (500), DL-lactide 13.1 g, glycolide 5.02 g and iso 50 mg of stannous octoate was dissolved in 150 ml of anhydrous toluene solution, reacted at 120°C for 24 hours under stirring, then lowered the temperature to 60°C, added coupling agent hexamethylene diisocyanate, and continued to react for 7 hours. After the reaction is completed, the toluene is removed under reduced pressure, the initial product is dissolved in methylene chloride solution, and ether is precipitated to obtain the macromonomer B' of the ABA type, and the yield is about 80%. In the macromonomer B' aqueous solution with a weight concentration of 20%, add a redox initiator potassium persulfate with a weight concentration of 1%, and chemically cross-link at 37°C to obtain a hydrogel. After the hydrogel reached swelling equilibrium in deionized water at 37°C, its weight swelling ratio was 1.4; after the temperature was lowered to 4°C, and ...

Embodiment 3

[0047] In the aqueous solution containing macromonomer A' and macromonomer B', wherein the weight percentage concentration is 10% and 15% respectively, potassium persulfate is added as an initiator, and tetramethylethylenediamine is used as an accelerator, at 25°C Under chemical cross-linking, a hydrogel is obtained. After the hydrogel reached swelling equilibrium in deionized water at 37°C, its weight swelling ratio was 2.0; after the temperature was lowered to 4°C, and then waited for swelling equilibrium, its weight swelling ratio was 7.1.

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Abstract

The invention discloses a decomposable temperature-sensitive chemical crosslinking gel and making method in the macromolecular material technical domain, which is characterized by the following: adopting PEG as hydrophilic block and decomposable polyester as hydrophobic block to form the host of temperature sensitive amphipathy block copolymer; forming gel under human body temperature (or normal temperature) in the water; using macromolecular monomer technique to obtain stable chemical crosslinking gel as drug slow-release carrier or culture rack of tissue engineering cell.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a degradable temperature-sensitive chemically cross-linked hydrogel and a preparation method thereof. Background technique [0002] In the past two decades, the advancement of genetic engineering technology and related technologies has promoted the development of peptide and protein drugs. However, peptide and protein drugs are easily degraded in the gastrointestinal environment and have a short half-life. At the same time, the solubility and stability of peptide and protein drugs in water are also difficulties faced by peptide and protein drugs. These all limit the application of peptide and protein drugs, and most of the commonly used drug delivery methods are not suitable for peptide and protein drugs. [0003] Pharmaceutical polymer carriers and preparations have been developed for many years. A major feature of this type of material is that it can be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L87/00C08G81/00C08G65/00C08G63/02C08G64/00C08F20/10
Inventor 丁建东俞麟
Owner ZHEJIANG TRIPLE WIN MEDICAL APPLIANCE
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