102results about "Bis-indole indigos" patented technology

PCT No. PCT/JP97/02858 Sec. 371 Date Oct. 30, 1997 Sec. 102(e) Date Oct. 30, 1997 PCT Filed Aug. 19, 1997 PCT Pub. No. WO98/07705 PCT Pub. Date Feb. 26, 1998A compound of the formula: wherein Q is an optionally substituted carbon atom or N(O)p wherein p is 0 or 1; Y is an optionally substituted methylene group, S(O)q wherein q is an integer of 0 to 2, or an optionally substituted imino group; Z1 is a C1-3 alkylene group which may have an oxo group or a thioxo group and may contain etherified oxygen or sulfur within the carbon chain; Z2 is an optionally substituted C1-3 alkylene group; Ar is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; one of R1 and R2 is a hydrogen atom, a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group; the other is a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group; or R1 and R2 taken together with adjacent -c=c- form a ring; and ring A is a benzene ring which may be substituted in addition to R1 and R2; or a salt thereof.

Chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity, and compounds represented by the following the general formula (I) or the general formula (XI) for introducing the chiral auxiliaries.

Compounds and compositions including 6-bromo-indirubin, 5-amino-indirubin and N-methyl-indirubins and related indirubin derivatives are provided that are useful as selective modulators of glycogen synthase kinase-3, cyclin-dependent protein kinases or aryl hydrocarbon receptors. Methods of inhibiting or modulating cell growth or cell cycling are provided using the compounds of the invention. In other aspects, compounds and methods for the treatment of protozoan-mediated diseases, Alzheimer's disease and diabetes are provided.

A compound called NATURA, which is a derivative of Isoindigo is useful in aiding the general health of a patient and specifically is beneficial in preventing or treating cancer. This compound and other related Isoindigo, Indigo and Indirubin derivatives are designed such that the bioactivity or bioavailability of the compound is increased. Methods of synthesizing these derivatives is also taught. In addition, pharmaceutical compositions that include a therapeutically effective amount of at least one of these derivatives and a pharmaceutically acceptable carrier. A method for the use of these pharmaceutical compositions and compounds is taught, wherein a therapeutically effective amount is administered to an animal having solid tumor cancer. The pharmaceutical composition or compound can be re-administered to the animal until a desired treatment or result is accomplished.

The present invention includes a paint or coating composition comprising an organic pigment or dye complexed to the surface of a layered or fibrous inorganic clay. A wide variety of paint colors can be obtained by varying the pH during the preparation as well as by varying the synthesis conditions and changing particle size of the clay.

An object of the present invention is to obtain color filters having a high contrast, a high color purity and an improved transmittance for blue color, and a display using the color filters. In the present invention, there is used a colored composition for color filter comprising at least one coloring agent, a base polymer and at least one solvent, said base polymer containing a polyamicacid whose light transmittance decreases by 2% or less in the visible region (wavelength: 400 nm to 800 nm).

A SMAC mimetic and pharmaceutical compositions thereof and methods of use.

The present invention is directed to N-linked lactam compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

The present invention involves new compositions comprising an organic pigment or dye complexed with a support via a coordinate covalent bond. The support is characterized has having a Lewis acid or Lewis acid substitute.

Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.

The invention discloses a method for recycling an indigo dye from the indigo waste coloring water. In the method, a proper filtration fabric is selected first for filtering the fibers and impurities in the waste water; then an acid liquid is added into the waste water the fibers and impurities of which are removed to adjust the pH value between 2 and 7; air is blown for oxidation to oxidize sodium salt of a water-soluble indigo leuco body into an insoluble solid indigo dye; finally the indigo dye and a condensed liquid which is rich in the dye are obtained through a microfiltration membrane device. The method has the advantages of less investment and simple device; the recycled indigo dye and the recycled condensed liquid can be recycled for coloring a fabric; besides, after the indigo waste coloring water is treated by the membrane, the chroma, the turbidity and the COD, and the like, are greatly reduced. The removing rate of effluent color dilution after the membrane treatment is larger than 98 percent; the turbidity is reduced by more than 97 percent and the COD removing rate is larger than 30 percent.

The invention relates to an iso-indigo derivative and applications of the iso-indigo derivative. The is formed by chemical modification on iso-indigo (matrix), i.e., one end is connected with different electron donating groups, while the other is connected with carboxyl groups which are electron withdrawing groups and used for being adsorbed on TiO2, therefore a series of electronic push-pull type compounds. As the matrix of the iso-indigo derivative serves as a conjugated system, the iso-indigo derivative has a good plane structure; as the iso-indigo derivative is connected with the electrondonating groups and the electron withdrawing groups, the electrons are easy to transfer in an excitated state, so that the iso-indigo derivative generate unique photoelectrochemical properties and can be used as a photosensitizer of dye sensitized solar cells.

The present invention includes methods, articles, compositions and colorant dyes and pigments that include biocidal N-halamine dye composition having two or more heterocyclic ring structures attached to one or more N-halamine groups, wherein one or more halogens associate with the one or more one or more N-halamine groups to affect biocidal activity.

The present invention relates to an indirubin derivative having anticancer property by inhibiting cell proliferation as to human cancer cell line. More particularly, this invention provides the synthesis of indirubin derivative known as CDK(Cyclin-dependent kinase) inhibitor. Further, inhibition activity of proliferation as to human cancer cell line and apoptosis against induced-differentiation of said indirubin derivative are researched to develop a novel indirubin derivative having efficacious anticancer properties as to various human cell lines.

Compounds of Formula (I) or (II) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.

The present invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and/or human breast cancer cell.

The invention discloses a method for preparing high dye-uptake anti-decolorization indigo dyeing water from indigo paste, comprising steps of: (1) soft water preparation: taking and heating clear water until the temperature of the water closes the boiling point, adding plant ash, depositing after stirring, filtering off dregs and to obtain soft water; (2) solution preparation: adding indigo paste and rice wine after the soft water cools, stirring well and to obtain an indigo paste aqueous solution; (3) sealed fermentation: adding the indigo paste aqueous solution into a thermal insulation dyeing pool, sealing by capping a plastic foil, still standing to fermentation for a fermentation time determined by season and the temperature of the dyeing pool; (4) observation: after 72 hours of fermentation, sealing off, observing, and recoding the status of fermentation every day at regular time; and taking samples by a white pottery and observing with shaking after the solution becomes light yellow, dyeing water with dyeing activity being the solution presenting light blue flowing "cloud"; (5) preservation and standby application: canning the dyeing water and placing the dyeing water in a shade place for preservation and standby application. The method solves the problem of activity of indigo paste, provides dyes for batik, and lays down a foundation for developing batik products.

The present invention relates to a new post-treatment process for an indigo blue oxidation filter cake obtained in an oxidation work section during an indigo blue dye production process. The process comprises that: an indigo blue oxidation filter cake in a plate frame with no washing or proper washing is taken out and placed into a stirring kettle; a proper amount of dilution water is poured; an acid substance is added while stirring to carry out a complete neutralization reaction, wherein the acid substance comprises four substances such as hydrogen chloride, sulfuric acid, phosphoric acid and carbon dioxide and concurrently comprises aqueous solutions of the four substances; and the neutralization reaction produces corresponding salts, and a filtration method is adopted to separate the salts and the indigo blue, wherein the indigo blue is slightly washed and is added to a finished product work section, the salts can be treated by adopting targeted methods according to the added different acids, hydroxides can be recovered from carbonates by adopting a causticization method, hydroxides can be recovered from chlorides by adopting an electrolysis method, and sulfates and phosphates can be sold after refinement. According to the invention, alkali consumption can be substantially reduced, an indigo blue yield can be increased, and the total amount of wastewater can be reduced.

The invention discloses a method for preparing purified indigo blue, involving a device main body and a centrifugal device arranged in the device main body, wherein the centrifugal device comprises afirst cavity formed in the device main body and having an upward opening, a second cavity is formed in the inner wall of the lower side of the first cavity, a first slide block is slidably arranged inthe second cavity, a third cavity with a rightward opening is formed in the first slide block, a first motor is fixedly arranged in the inner wall of the right side of the second cavity, the left endof the first motor is in power fit connection with a first cam, extending into the second cavity, by a rotary shaft, and the upper and lower ends of the first cam are respectively abutted against theinner walls of the upper and lower sides of the second cavity. The invention aims to design the method capable of automatically smashing indigo blue and squeezing indigo blue juice therein.