The invention discloses a crane safety fastening device which is characterized in that front concrete sleepers and rear concrete sleepers are sequentially arranged on the lower sides of steel rails, two anti-creeping fixtures are sequentially arranged on the left sides and the right sides of the steel rails respectively, clamp slots are formed in the upper ends of the anti-creeping fixtures, vertical screw holes are formed in the front and back sides of the anti-creeping fixtures, vertical distance adjusting lead screws are placed in the vertical screw holes, horizontal screw holes are formed in the left sides and the right sides of the anti-creeping fixtures, horizontal distance control screw rods are arranged in the horizontal screw holes, bases are arranged at the bottom ends of the steel rails, and the anti-creeping fixtures are clamped on the bases of the steel rails through the clamp slots. The crane safety fastening device is simple in structure and reasonable in design, the steel rails and the concrete sleepers can be locked into a whole after the anti-creeping fixtures are mounted, telescopic movement caused by vehicle passing and thermal expansion and contraction change of the steel rails is effectively controlled, stability of rail gaps of steel rail joints is ensured, daily maintenance workload is decreased, equipment safety risk is reduced, and the utilization rate of track lines is increased.