The invention discloses a construction method and application of a safety evaluation risk prediction model after child medication marketing, and the method comprises the steps: constructing a three-level
index system, and determining the weight of each level of index through an
analytic hierarchy process; based on the three-level
index system, determining a risk
feature set, constructing a three-level
model architecture, and performing model training by adopting a
machine learning
algorithm; collecting multi-source
real world data, and establishing a standardized data
pool; the performance of the model is improved through hyper-parameter optimization and integrated learning, the performance of the model is verified and evaluated by adopting internal
cross validation and an external
independent data set, and the transparency of the model is enhanced through an
interpretability technology; and establishing a dynamic updating mechanism, deploying the model as a cloud API service, and realizing risk prediction and early warning functions. According to the invention, multi-source
real world data can be effectively integrated, the children medication
safety risk can be accurately identified, the method is used for safety evaluation after children medication is listed, and the method is of great significance to supplement clinical test insufficiency before children medication is listed, reduce
medication risk and guarantee children medication safety.