NMR contrast agent and preparation method thereof

A technology of nuclear magnetic resonance imaging and contrast agent, which can be applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, etc., can solve the problems of limiting the application of carbon-coated nanomaterials, unfavorable practical application, and difficult to externally externally modify groups or targeting reagents, etc.

Inactive Publication Date: 2007-08-08
XIAMEN UNIV
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  • Application Information

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Problems solved by technology

The resulting problem is that the surface of carbon-coated nanoparticles has strong hydrophobicity, which is not conducive to practical applications, and because of the high chemical stability of carbon, it is not easy to add external modification groups or targeting reagents, thus limiting the ability of carbon Application of Encapsulated Nanomaterials

Method used

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  • NMR contrast agent and preparation method thereof
  • NMR contrast agent and preparation method thereof

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Embodiment 1

[0017] Example 1: at room temperature, 40 mg of ferric nitrate as an iron source is dissolved in 10 ml ethanol to form a solution with a mass percentage of 0.5%; 45 mg of decachloropyrene as a carbon source is dissolved in 1 ml toluene to form a mass percentage of 5% solution. Use ammonia water to adjust the pH value of the ethanol solution of ferric nitrate to 8, then mix it with the toluene solution of decachloropyrene, and dilute to 25ml with water. Pour the mixed solution into a polytetrafluoroethylene reactor and seal it in a stainless steel reactor. The reactor was heated to 200°C and kept for 48h. After cooling, pour out the solution in the reactor, collect the insoluble matter, wash and dry to obtain nano-scale carbon-coated iron oxide particles (as shown in Figure 1). Fig. 2 is the X-ray diffraction spectrogram of product, proves that product is ferric oxide; Fig. 4 is the Raman spectrogram of product, proves that carbon shell layer is made of graphitic carbon and p...

Embodiment 2

[0018] Example 2: 40 mg of ferric sulfate as an iron source was dissolved in 5 ml of methanol to form a solution of 2.5% by mass; 225 mg of hexachlorobenzene as a carbon source was dissolved in 2 ml of benzene to form a solution of 2% by mass; Adjust the pH value of the iron source solution to 10, and react at 250° C. for 24 hours. All the other are with embodiment 1, product result is with embodiment 1.

Embodiment 3

[0019] Embodiment 3: Similar to Embodiment 1. The difference is that 40 mg of ferric chloride as an iron source is dissolved in 1 ml of propanol to form a solution of 5% by mass; 450 mg of hexabromobenzene as a carbon source is dissolved in 10 ml of xylene to form a 5% solution by mass solution; adjust the pH of the iron source solution to 12. Heated to 100°C and kept for 72h. Product result is with embodiment 1.

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Abstract

The invention relates to a method for preparing nuclear magnetic resonance developing agent, especially relating to a carbon-coat nanometer ferric oxide with surface decoration. The invention is formed by nanometer ferric oxide, carbon and amido group, which uses the nanometer ferric oxide as corn, coated by the carbon case connected with amido group. The preparation comprises that mixing the iron source and carbon source at 1:1-10 mol ratio, to react at 120-250Deg. C for 12-72h, to obtain the nanometer carbon-coat ferric oxide particles. The invention coats the nanometer ferric oxide particles with carbon layer to improve the chemical stability, while the product can stably live in 1M alcaine solution for more than four months, to avoid iron ion intoxication. And the invention leads in surface decoration group to reduce the Zeta potential value of product under -30mV in weak-acid and neutral conditions, and improve the surface hydrophilicity without accumulation. The invention has strong respond signal of nuclear magnetic resonance.

Description

technical field [0001] The invention relates to a contrast agent, in particular to a surface-modified carbon-coated nano-iron oxide, which is mainly used as a contrast agent for nuclear magnetic resonance imaging. Background technique [0002] The contrast agents currently used in MRI can be divided into two types in terms of chemical composition: transition metal complexes and magnetic iron oxide nanoparticles. The transition metal complex type is mainly gadolinium complex type. Magnetic iron oxide nanoparticles have attracted wide attention in recent years because of their low chemical toxicity, low clinical dose and potential for magnetic resonance target imaging. However, the biotoxicity research of iron oxide nanoparticles is not comprehensive enough, and it is necessary to avoid the aggregation of nanoparticles during use or storage. A general solution is to use biocompatible macromolecules or polymers (such as starch and dextran), wrap the nanoparticles in the cente...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06
Inventor 翁建王晓峰张其清
Owner XIAMEN UNIV
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