Improved method of synthesizing emodin

A technology of emodin and cyclization, which is applied in the field of synthesis and improvement of the main component emodin, can solve the problem of low yield and achieve the effect of increasing the total yield
CN101033178AInactive Publication Date: 2007-09-12NANJING RALLY BIOCHEM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING RALLY BIOCHEM
Publication Date
2007-09-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates a synthesizing and reforming method for rheum emodin, which takes 3, 5-dinitroalizaric acid as the starting material to be reacted through Ke Fu acylation, recovery, circulation and diazo reactions to get the total yield of 50.8%, in which, nitryl is recovered by catalyzation and hydrogenation, oil of vitriol and acetic acid as the medium, glycol mono-aether as the assistant solvent to increase the reaction yield rate of diazo reaction.
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Description

field of invention

[0001] The invention relates to the field of organic and medicinal chemistry, in particular, the invention relates to an improved method for synthesizing emodin, the main component of rhubarb, a traditional Chinese medicine. Background technique

[0002] Emodin is one of the main components extracted from the rhizome of Rheum palmatum, a plant of the Polygonaceae family. It has antibacterial, anticancer activities, catharsis and diuretic effects. Emodin is the main raw material for the synthesis of hypericin.

[0003] Emodin, also known as 1,3,8-trihydroxy-6-methylanthraquinone, English name: Emodin, its structural formula is as follows:

[0004]

[0005] Emodin

[0006] Since rhubarb contains various components such as chrysophanol, rhein, emodin and aloe-emodin, the process of extracting and separating monomer emodin from rhubarb, or obtaining emodin by hydrolyzing the extract aloe-emodin is cumbersome and costly. High...

Claims

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