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Method of preparing organization bracket performing selectivity laser sintering by using macromolecule microsphere

A technology of polymer microspheres and tissue scaffolds, applied in the field of biomedical materials, can solve the problems of insufficient forming precision, inaccurate particle size control, irregular powder shape, etc., and achieve high forming precision, controllable particle size range, Easy sintering effect

Inactive Publication Date: 2008-03-12
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the powders used in sintering are obtained by mechanical pulverization. The shape of the powder is irregular and the particle size control is not precise, which leads to large horizontal displacement during laser sintering and insufficient forming accuracy.
[0005] When using selective laser sintering to prepare organic / inorganic composite bone tissue engineering scaffolds, the method of mechanically mixing polymer powder and apatite powder is generally used at present, which is difficult to sinter and has poor mechanical properties.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]Take 2g of poly-L-lactic acid (PLLA, the molecular weight is 10,000) and dissolve it in 10ml of dichloromethane (that is, the concentration is 0.20g / ml), until fully dissolved, this is solution A; take 0.2% polyvinyl alcohol (PVA) Dissolve in 300ml of water, place it on a stirrer and stir at a speed of 400rpm. After fully dissolving, this solution is B; pour A solution into the stirring B solution at a constant speed to obtain solution C; continue to stir solution C for 8 hours to make organic The solvent is evaporated; then the PVA is washed away by natural sedimentation, the PLLA microsphere powder is collected into the Erlenmeyer flask, ultrasonically dispersed, placed in -20°C for 12 hours, and then placed in a freeze dryer at -50°C. Freeze-dry for 24 hours under the condition of less than 20Pa to obtain PLLA microspheres; use Pro / E software to design a cylindrical scaffold with a diameter of 10mm and a height of 3mm, and export it as a .stl format file; The mass rat...

Embodiment 2

[0033] Get 2g chitosan (molecular weight is 100,000) and dissolve in 13ml 1% acetic acid aqueous solution (that is, concentration is 0.15g / ml), wait for fully dissolving, this is solution A; Get 0.3% polyethylene glycol and dissolve in 300ml water, Place it on a stirrer and stir at a speed of 400rpm. After fully dissolving, this solution is B; pour solution A into solution B which is being stirred at a constant speed to obtain solution C; continue to stir solution C for 12 hours to volatilize the acetic acid; Wash away the polyethylene glycol by filtering, collect the chitosan microsphere powder into the conical flask, disperse it ultrasonically, put it into -20°C for pre-freezing for 12 hours; put it into a freeze dryer at -50°C after pre-freezing, Freeze-dry under 20Pa condition for 24 hours to obtain chitosan microspheres; use Pro / E software to design a cylindrical support with a diameter of 10mm and a height of 3mm, and export it as a .stl format file; the chitosan microsph...

Embodiment 3

[0036] Take 2g of poly-DL-lactic acid (PDLLA, molecular weight is 600,000) and dissolve in 16ml of acetone (that is, the concentration is 0.125g / ml), until fully dissolved, this is solution A; take 0.5% poloxamer 188 (poloxamer -188) was dissolved in 300ml water, placed on a stirrer and stirred at a speed of 400rpm. After fully dissolving, this solution was B; Pour A solution into the B solution being stirred at a uniform speed to obtain solution C; Solution C continued to stir for 8 Volatilize the organic solvent within 1 hour; then use ultrafiltration to wash away poloxamer-188, collect PDLLA microsphere powder into a conical flask, disperse it ultrasonically, put it into -20°C for 12 hours, and put it into a freeze dryer after prefreezing Freeze-dry at -50°C and less than 20 Pa for 24 hours to obtain PDLLA microspheres; use Pro / E software to design a cylindrical scaffold with a diameter of 10mm and a height of 3mm, and export it as a .stl format file; the PDLLA microspheres ...

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Abstract

The present invention discloses a manufacture method of a tissue frame, which conducts the selective laser sintering by the polymer micro spheres. The method comprises the following steps. The polymer material dissolved in the solvent is dropped in the dispersant under stirring status at a uniform speed. The polymer micro spheres are obtained after cleaning, ultrasound dispersion and freezing preparation. The mixing powder is obtained after mixing the polymer micro spheres with a pore-foaming agent. A three-dimensional model of the frame is designed by the computer assistant software. The mixing powder is formed by the selective laser sintering according to the three-dimensional model; therefore the frame is produced. The polymer micro spheres produced by the method in the present invention have regular shapes and adjustable particle diameter. The method is simple and practical. The mechanical property of the frame after forming is excellent. The horizontal movement between the layers is small and the forming accuracy is high.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a method for manufacturing a tissue bracket using selective laser sintering, in particular to a method for manufacturing a tissue bracket using polymer microspheres for selective laser sintering. Background technique [0002] Tissue engineering scaffolds can be prepared by fiber bonding, solvent casting, particle filtration, melting, membrane lamination, phase separation, and freeze-drying. However, the performance of the scaffold prepared by this method is not ideal, mainly in the low degree of interpenetration of pores, poor controllability of porosity and pore distribution, which will directly affect the growth of cells and the vascularization of tissues. Rapid prototyping technology can effectively solve this problem. Rapid prototyping technology is a comprehensive technology integrating new material science, computer-aided design, and numerical control technology. Accordin...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/12A61F2/28
Inventor 张胜民周娇娇仇志烨
Owner HUAZHONG UNIV OF SCI & TECH
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