Lactase sheet and preparing method thereof

Abstract

The invention discloses a tablet formulation against lactose intolerance and alactasia and the preparation method. The formulation includes active ingredient lactase, excipient diluent agent, disintegrating agent, binder, wetting agent, glidant and lubricant. Among starch, microcrystalline cellulose, mannitol and pre-gelatinized starch, one ingredient or more than two ingredient compound can be chosen as diluent agent (filling agent); one or more ingredients can be chosen from carboxymethyl starch, crosslinking sodium carboxymethyl cellulose, crosslinking povidone, low-substituted hydroxypropyl cellulose, microcrystalline cellulose and pre-gelatinized starch as disintegrating agent; one ingredient can be chosen from povidone, starch pulp and any cellulose as binder; one ingredient can be chosen from micro-powder silica gel and talcum powder to be used as glidant; one ingredient can be chosen from magnesium stearate, calcium stearate, stearic acid, hydrogenated vegetable oil and carmowax as lubricant; one ingredient can be chosen from ethanol, water and ethanol water as wetting agent.

Description

technical field [0001] The invention relates to a lactase tablet and a preparation method thereof. Background technique [0002] Lactose is the main carbohydrate in milk, accounting for about 4.4% of milk (about 7.2% in human milk). Lactose is a disaccharide in which D-glucose (Glucose) and D-galactose (Galactose) are bonded by β-1,4. Lactose only exists in the milk of mammals, and is the most important energy source for human infants, but not all mammals contain lactose (for example, the milk of sea animals such as whales and seals does not contain lactose. lactose). Lactose has the following three physical characteristics: 1. Poor solubility: This is the main problem when dairy products are processed. 2. Low sweetness: the sweetness of α-state lactose is only 16-18 of the sweetness of sucrose (calculated as 100 of sucrose). 3. Indigestibility: The absorption efficiency of lactose is only 1 / 32 of that of glucose. [0003] Lactose has the effect of promoting calcium abs...

AI Technical Summary

Problems solved by technology

Lactose has the following three physical characteristics: 1. Poor solubility: This is the main problem in dairy product processing

2. Low sweetness: the sweetness of α-state lactose is only 16-18 of the sweetness of sucrose (converted with sucrose as 100)

3. Indigestible: the absorption efficiency of lactose is only 1 / 32 of that of glucose

[0007] With the improvement of my country's economic level and living standards, people's intake of milk is increasing. However, due to the lack of lactase in the epithelial cells of the small intestine, many people cannot decompose and absorb lactose after drinking milk. After lactose enters the colon, it is absorbed by intestinal bacteria. Decomposition produces a large amount of short-chain fatty acids such as lactic acid and formic acid and hydrogen gas, which increases the osmotic pressure and increases the water in the intestinal cavity, causing abdominal distension, bowel sounds, intestinal colic, and even diarrhea, which undoubtedly limits people's appreciation of milk. intake