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A technology of lactase tablet and lactase, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem that lactose cannot be decomposed and absorbed, poor solubility, indigestibility, etc. question
Inactive Publication Date: 2008-06-18
郭炳华 +2
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Abstract
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Problems solved by technology
Lactose has the following three physical characteristics: 1. Poor solubility: This is the main problem in dairy product processing
2. Low sweetness: the sweetness of α-state lactose is only 16-18 of the sweetness of sucrose (converted with sucrose as 100)
3. Indigestible: the absorption efficiency of lactose is only 1 / 32 of that of glucose
[0007] With the improvement of my country's economic level and living standards, people's intake of milk is increasing. However, due to the lack of lactase in the epithelial cells of the small intestine, many people cannot decompose and absorb lactose after drinking milk. After lactose enters the colon, it is absorbed by intestinal bacteria. Decomposition produces a large amount of short-chain fatty acids such as lactic acid and formic acid and hydrogen gas, which increases the osmotic pressure and increases the water in the intestinal cavity, causing abdominal distension, bowel sounds, intestinal colic, and even diarrhea, which undoubtedly limits people's appreciation of milk. intake
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Embodiment 1
[0034] Formula 1: Each 1000 tablets contains 30g of lactase:
[0035] Lactase 15%
[0036] Microcrystalline Cellulose 32%
[0037] Mannitol 45%
[0038] Sodium Carboxymethyl Starch 5%
[0039] 5% PVP75% ethanol solution 2%
[0040] Micronized silica gel 0.5%
[0041] Magnesium Stearate 0.5%
[0042] Preparation:
[0043] 1. Pass the active ingredient lactase and all auxiliary materials through a 100-mesh sieve for later use, weigh the formula amount of microcrystalline cellulose, mannitol and disintegrant, and mix well;
[0044] 2. Weigh the amount of lactase in the above formula, add it to the mixed auxiliary materials by equal incremental dilution method and mix evenly;
[0045] 3. Prepare soft materials with 5% povidone and 75% ethanol solution, and granulate with 20 mesh sieves;
[0046] 4. After drying the wet granules obtained above at 60°C, use a 18-mesh sieve to sieve the granules;
[0047] 5. Weigh the micropowder silica gel and magnesium stearate of the abov...
Embodiment 2
[0050] Formula 2: Each 1000 tablets contains 60g of lactase:
[0051] Lactase 20%
[0052] Microcrystalline Cellulose 30%
[0053] Mannitol 42%
[0054] Croscarmellose Sodium 3%
[0055] Hypromellose 4%
[0056] Micronized silica gel 0.2
[0057] Magnesium Stearate 0.8%
[0058] Preparation method is the same as embodiment 1
Embodiment 3
[0060] Formula 3: Contains 90g of lactase per 1000 tablets:
[0061] Lactase 30%
[0062] Microcrystalline Cellulose 25%
[0063] Mannitol 36%
[0064] Croscarmellose Sodium 3%
[0065] Sodium Carmellose 5%
[0066] Micronized silica gel 0.4%
[0067] Magnesium Stearate 0.6%
[0068] Preparation method is the same as embodiment 1
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Abstract
The invention discloses a tablet formulation against lactose intolerance and alactasia and the preparation method. The formulation includes active ingredient lactase, excipient diluent agent, disintegrating agent, binder, wetting agent, glidant and lubricant. Among starch, microcrystalline cellulose, mannitol and pre-gelatinized starch, one ingredient or more than two ingredient compound can be chosen as diluent agent (filling agent); one or more ingredients can be chosen from carboxymethyl starch, crosslinking sodium carboxymethyl cellulose, crosslinking povidone, low-substituted hydroxypropyl cellulose, microcrystalline cellulose and pre-gelatinized starch as disintegrating agent; one ingredient can be chosen from povidone, starch pulp and any cellulose as binder; one ingredient can be chosen from micro-powder silica gel and talcum powder to be used as glidant; one ingredient can be chosen from magnesium stearate, calcium stearate, stearic acid, hydrogenated vegetable oil and carmowax as lubricant; one ingredient can be chosen from ethanol, water and ethanol water as wetting agent.
Description
technical field [0001] The invention relates to a lactase tablet and a preparation method thereof. Background technique [0002] Lactose is the main carbohydrate in milk, accounting for about 4.4% of milk (about 7.2% in human milk). Lactose is a disaccharide in which D-glucose (Glucose) and D-galactose (Galactose) are bonded by β-1,4. Lactose only exists in the milk of mammals, and is the most important energy source for human infants, but not all mammals contain lactose (for example, the milk of sea animals such as whales and seals does not contain lactose. lactose). Lactose has the following three physical characteristics: 1. Poor solubility: This is the main problem when dairy products are processed. 2. Low sweetness: the sweetness of α-state lactose is only 16-18 of the sweetness of sucrose (calculated as 100 of sucrose). 3. Indigestibility: The absorption efficiency of lactose is only 1 / 32 of that of glucose. [0003] Lactose has the effect of promoting calcium abs...
Claims
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Application Information
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