Biodegradable compound powder-style hemostasis material

A hemostatic material and biodegradable technology, applied in the field of medicine, can solve the problems of not easy to penetrate the bleeding part, difficult to achieve hemostasis, affect the hemostatic performance, etc., achieve good hemostatic effect, easy to pressurize hemostasis, and long-term storage

Inactive Publication Date: 2009-11-11
官培龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it also has defects: first, the starch granules are small and light, and when sprayed on the bleeding wound, they often float on the surface of the bleeding blood flow, so when using it, the doctor needs to press the hemostatic powder on the wound; second, its hemostatic powder When encountering blood, it often undergoes denaturation, starch itself coalesces, and it is difficult to penetrate into the bleeding site; especially for active bleeding, it is difficult to achieve the purpose of hemostasis; Chlorohydrins are used as cross-linking agents; Fourth, the price is expensive
This seriously affects its hemostatic properties
[0006] At present, there is no powder hemostatic material in China that has a fast onset of hemostatic effect, good adhesion to the wound surface, a certain penetration ability, and a certain promotion effect on wound healing, and is reasonably priced.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of cross-linked microporous starch:

[0032] Raw starch pretreatment (gelatinization and ultrasonic treatment): prepare various selected raw starches into 30%--40% (w / v) cross-linked starch emulsion, stir at 50°C-90°C, 1 -Turn off the heat after 30 minutes. Centrifuge, precipitate 30--50 normal pressure, dry and pulverize. Measure the gelatinization degree of starch, and determine the gelatinization degree of 10%--40%. The pre-gelatinized starch is prepared into an emulsion, and treated with an ultrasonic wave at 10-50 kHz for 30 minutes to 50 minutes without stirring.

[0033] Preparation of microporous starch by enzymatic hydrolysis: Add the pretreated starch emulsion to the enzyme solution (1 part of α-amylase) prepared in buffer, and react for 20-24 hours to obtain wet microporous starch.

[0034] Vacuum freeze-drying: After the wet microporous starch is made into a suspension with distilled water, it is placed in the refrigerator to make ice cubes, a...

Embodiment 2

[0037] Preparation of chitosan / alginic acid composite microsphere powder:

[0038] Preparation of related solutions: Dissolve 1 g of sodium alginate in 100 ml of distilled water, and stir with a magnetic stirrer at room temperature at 50 r / min for 4 hours to obtain a sodium alginate milky solution. Dissolve 1 g of chitosan in 100 ml of distilled water, and stir with a magnetic stirrer at room temperature at 50 r / min for 1 hour to obtain an undissolved colloidal chitosan solution. Add 1g of calcium chloride to 40ml

[0039] In distilled water, stir with a magnetic stirrer at room temperature at 50 r / min for 1 hour, and obtain a clear calcium chloride solution after filtration.

[0040]Preparation of chitosan / alginic acid composite microspheres: Add 100ml of sodium alginate emulsion solution to 100ml colloidal chitosan solution, stir evenly at room temperature to form a stable colloidal solution. Stir 1000ml liquid paraffin with 75ml Tween-80 in the reaction bottle at room tem...

Embodiment 3

[0043] Use 10 grams of potato cross-linked microporous starch dry powder and 5 grams of white chitosan / alginic acid composite microsphere powder to mix directly. After being sterilized by Co60 irradiation, bottle and seal to make a biodegradable high-efficiency compound powder body hemostatic material.

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PUM

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a biodegradable compound powder-style hemostasis material composed of cross-linked porous corn starch and chitosan/alginic acid compound microballoon. The chitosan adopted by the hitosan/alginic acid compound microballoon can be carboxymethyl chitosan or a compound of a plurality of chitosan with different degrees of deacetylation and different molecular weights, or can be multiaperture chitosan microballoon or other derivatives of chitosan. The cross-linked porous corn starch can be prepared by one or at least two types of the following materials: sweet potate starch, potato starch, cassava starch, corn starch, rice starch, long-shaped rice starch, sago starch, mung bean starch, wheat starch, water caltrop starch, lotus-root starch, sorghum starch and radix puerariae starch, or can be prepared by etherified modified starch or etherified and cross-linked compound modified starch. The biodegradable compound powder-style hemostasis material provided by the invention has simple and convenient preparation process, low cost, quick hemostasis effect and good performance.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a biodegradable high-efficiency compound powder hemostatic material. Background technique [0002] Hemorrhage is not only the first cause of death from war injuries, but also the second cause of death from trauma, and it is also the main cause of death in operating room patients. The treatment of hemorrhage in solid organ wounds is a difficult problem for surgeons. [0003] At present, commonly used hemostatic materials include oxidized cellulose and oxidized regenerated cellulose, collagen material preparations, chitosan and its derivative materials, fibrin glue, gelatin sponge and gelatin fiber mesh, alginate materials and microporous polysaccharides for hemostasis ball. Various animal experiments and clinical applications have been fully affirmed, but different hemostatic materials have different hemostatic mechanisms, as well as the corresponding advantages and limitations...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/60
Inventor 官培龙饶蓉郭新洪
Owner 官培龙
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