Biological type highly cross-linked reticular sustained release ECMO coating material, preparation method and application thereof

Abstract

The invention relates to a biological type highly cross-linked reticular sustained release ECMO coating material, a preparation method and application thereof. The coating material is a complex mainly formed by combining a natural biological polysaccharide polymer with negative charges and an anticoagulative substance which reaches certain therapeutic concentration, and is prepared by combining the natural biological polysaccharide polymer with the negative charges and the anticoagulative substance in the form of physical blending and physical adsorption. The coating material has broad application prospect in the preparation of membrane lungs, blood pumps, ducts or intubations; and the coating material has important significance in the aspects such as the improvement on blood compatibility of coating ducts, the improvement on combination density of anticoagulative substances such as heparin and the like, the strengthening of the safety, the reduction of medical cost and the like.

Description

technical field [0001] The invention relates to a coating material and its preparation method and application, in particular to a bio-type highly cross-linked slow-release ECMO coating material and its preparation method and application. Background technique [0002] Cardiopulmonary failure is a serious global public health and clinical problem with high morbidity and mortality. The most effective method for end-stage cardiopulmonary disease is heart-lung transplantation, but the lack of donors limits the widespread development of heart-lung transplantation. Many patients die while waiting for heart transplantation or heart-lung transplantation, while others with reversible heart-lung failure are difficult to overcome. Passed a short critical pass and died. [0003] With the emergence of extracorporeal membrane oxygenation (ECMO) technology, the treatment rate of critically ill cardiopulmonary patients has been greatly improved. Extracorporeal membrane oxygenation (ECMO) i...

AI Technical Summary

Problems solved by technology

At present, the heparin coating methods can be roughly divided into three categories: (1) Ionic bonding method: the ionic bonding method is to introduce positively charged quaternary ammonium groups on the surface of polymer materials by utilizing the property of heparin itself with a large amount of negative charges. Group coupling agents, surfactants or polymers containing cations, and then interact with heparin to form a heparinized layer on the surface of the material by ionic bonds. Due to the instability of ionic bonds, plasma macromolecules such as albumin with affinity Substances can be combined with heparin to cause heparin molecules to fall off, so it can only be used for a short period of time; (2) Covalent bond method: This method generally uses the -CNS group, -NH2 group, -OH group, etc. on the surface of polymer materials The specific active group interacts with the -OH group of the heparin molecule to immobilize heparin, but because heparin has a large number of functional groups, it often binds too firmly with the surface of the material, resulting in the loss of activity of the heparin molecule, so the expected anticoagulation is often not obtained Effect; (3) End point immobilization method: The end point immobilization method first prepares a binding ion complex on the surface of the biological material, and then activates heparin through a controlled nitrous acid, and fixes heparin on the amino group-containing amino acid in a covalent bond. The surface of the material, this kind of fixing method is costly, and the peeling coating material will cause harm to the human body

[0005] In summary, the current heparin coating technology cannot achieve ideal biocompatibility and still has certain limitations. Therefore, the development of a new ECMO coating material is an important problem to be solved at this stage

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