Cephalosporin suspension granule and preparation method thereof

Abstract

The invention discloses a cephalosporin suspension granule of which the formula composition comprises drug active ingredients, excipient, suspending agent, disintegrating agent, flavoring agent, coloring agent, stabilizing agent, adhesive and spice. The granule takes cefixime, cefprozil, cefaclor or cefdinir as the main drug ingredient, disintegrating agent and suspending agent with a certain quantity are added into the formula to ensure that the effective ingredients are dissolved out, and the solution has favorable suspending effect. Meanwhile, the invention also discloses a preparation method of the cephalosporin suspension granule, which adopts the wet granulation method to prepare granules and adopts the fluidized bed drying method to dry. The invention adopts the fluidized bed drying technology, so that compared with the traditional oven drying, the invention has the advantages of short drying time, small influence on active matter quality and the like, not only ensures product quality but also improves production efficiency. The granule prepared by the formula of the invention has solid granularity and lowers damage to the granule by fluidized drying.

Description

technical field

[0001] The invention relates to a medicine and a preparation method thereof, in particular to a cephalosporin suspension granule and a preparation method thereof. Background technique:

[0002] Cephalosporins play a bactericidal effect by inhibiting bacterial cell wall synthesis and are stable to most β-lactamases. Many strains producing penicillinase and cephalosporinase are still sensitive to cephalosporins. Cephalosporins are effective in vitro and in vivo against Gram-positive cocci such as pneumococcus, Streptococcus pyogenes, Gram-negative bacilli such as influenza bacilli (including enzyme-producing strains), Moraxella catarrhalis (including enzyme-producing strains), Escherichia coli, Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains) all have good antibacterial effects. Cephalosporins in vitro against Streptococcus pneumoniae, Bacillus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Pasteurella multocida, Prov...

Images