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Method for separating octadecadienoic acid from mixed long-chain fatty acid

An octadecadienoic acid and long-chain fatty acid technology, which is applied in the field of chemical engineering, can solve the problems of unsuitable large-scale industrial production, low functional group density, small adsorption capacity, etc., and achieves easy recycling and processing, good product quality, Simple process effect

Active Publication Date: 2010-10-06
ZHEJIANG UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, this method has the following disadvantages: (1) the functional group density of the adsorbent is small and the adsorption capacity is small, resulting in a small amount of treatment and a large solvent consumption; Mainly, the mass transfer rate is slow
The application of supercritical fluid chromatography and simulated moving bed chromatography technology can reduce solvent consumption and improve the utilization rate of adsorbent, but these technologies require high equipment
[0007] In addition, patent documents US 6537787 and US 5470741 use lipase hydrolysis to purify unsaturated fatty acids. Although unsaturated fatty acids with higher purity can be obtained, the production cost is high and there are many steps, so it is not suitable for large-scale industrial production.

Method used

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  • Method for separating octadecadienoic acid from mixed long-chain fatty acid

Examples

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Effect test

Embodiment 1

[0028] Sunflower oil is subjected to saponification and isomerization reactions to obtain mixed long-chain fatty acids mainly containing conjugated linoleic acid, oleic acid, stearic acid and palmitic acid (the total content of fatty acids is 99%, wherein the content of conjugated linoleic acid is 70%). The prepared mixed long-chain fatty acids were dissolved in hexane to prepare a raw material solution with a total concentration of 40 g / L. Furfural is used as extractant, hexane is used as detergent, the volume flow ratio of raw material liquid, extractant, and detergent is 1:4:5, the extraction packing is 2mm stainless steel θ ring packing, fractional extraction is carried out at 40°C . The extract solution is vacuum evaporated to remove the solvent to obtain a conjugated linoleic acid product with a product purity of 99% and a product yield of 96.5%.

Embodiment 2

[0030]Safflower seed oil undergoes saponification and isomerization reactions to obtain mixed long-chain fatty acids mainly containing linoleic acid, oleic acid, stearic acid and palmitic acid (the total content of fatty acids is 99%, and the content of linoleic acid is 76%) , the prepared mixed long-chain fatty acids are dissolved in heptane, and the total concentration is 60g / L for preparation. Using dimethyl sulfoxide as the extractant and heptane as the detergent, the volume flow ratio of the raw material solution, the extractant and the detergent is 1:8:4, the extraction packing is 4mm stainless steel θ ring packing, at 40°C Extraction by fractional distillation. The extract was collected, and the solvent was evaporated in a vacuum to obtain a linoleic acid product with a product purity of 97% and a product yield of 95.3%.

Embodiment 3

[0032] Cottonseed oil undergoes saponification and isomerization reactions to obtain mixed long-chain fatty acids mainly containing conjugated linoleic acid, oleic acid, stearic acid, palmitic acid, and myristic acid (the total content of fatty acids is 99%, of which conjugated linoleic acid Acid content is 56%), and the prepared mixed long-chain fatty acid is dissolved in hexane, and is mixed with the raw material liquid that total concentration is 80g / L. Using dimethylformamide as extractant and hexane as detergent, the volume flow ratio of raw material liquid, extractant and detergent is 2:20:6, the extraction packing is 2mm stainless steel θ ring packing, at 30°C Extraction by fractional distillation. The extract was collected, and the conjugated linoleic acid product was obtained after vacuum evaporation to remove the solvent, the product purity was 95%, and the product yield was 90.1%.

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Abstract

The invention relates to a method for separating octadecadienoic acid from mixed long-chain fatty acid, which adopts a fractional extraction method to separate the octadecadienoic acid from the mixed long-chain fatty acid by taking one of acetonitrile, furfural, dimethyl sulfoxide, dimethylformamide, N-methyl-2-pyrrolidone and sulfolane or a mixture thereof as an extracting agent and one of petroleum ether the boiling range of which is 60-90 DEG C or 90-120 DEG C, hexane, heptane and octane or a mixture thereof as a detergent. The process adopts organic solvents commonly used in industry, andthe method has the advantages of simple process, high product quality, high yield, low production cost, high safety, environmental production, easy industrial production and the like.

Description

technical field [0001] The invention relates to a method for separating octadecadienoic acid from mixed long-chain fatty acids, in particular to a method for separating octadecadienoic acid by a fractional distillation extraction method, and belongs to the technical field of chemical engineering. Background technique [0002] Octadecadienoic acid is an unsaturated fatty acid containing two double bonds, which includes linoleic acid (Linoleic Acid) and conjugated linoleic acid (Conjugated Linoleic Acid). Linoleic acid is cis, cis-9,12-octadecadienoic acid, which exists in natural animal and vegetable oils and is an essential fatty acid for human body. Studies have shown that linoleic acid has physiological activities such as maintaining the integrity of cell membranes in the body, controlling cell metabolism, lowering cholesterol levels, and preventing and treating cardiovascular and cerebrovascular diseases. Conjugated linoleic acid is octadecadienoic acid containing conjug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C57/12C07C51/48
Inventor 杨亦文刘瑞阳邢华斌苏宝根任其龙苏云
Owner ZHEJIANG UNIV
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