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Preparation method of slice-shaped B type carbonate phosphorite

A carbonate-type, apatite technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of poor biodegradability, harsh reaction conditions, long reaction time, etc. Effects of milder conditions, improved safety and energy consumption

Inactive Publication Date: 2010-12-22
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The hydrothermal method is used to prepare hydroxyapatite, the reaction conditions are harsh, and it needs to be carried out under high temperature and high pressure, which lacks safety, and the reaction time is long, the energy consumption is large, and the production cost is high.
Synthetic hydroxyapatite has good biocompatibility and osteoconductive activity, but its biodegradability is poor due to its high crystallinity, and it will remain in the organism for life after implantation

Method used

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  • Preparation method of slice-shaped B type carbonate phosphorite
  • Preparation method of slice-shaped B type carbonate phosphorite
  • Preparation method of slice-shaped B type carbonate phosphorite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Preparation of calcium carbonate powder: Calcium carbonate is mechanically ground to form a powder with a particle size of about 1 μm.

[0024] 2. Preparation of phosphate buffer solution: Dissolve sodium dihydrogen phosphate and disodium hydrogen phosphate in distilled water to prepare a phosphate buffer solution with pH=7.4 and total phosphate concentration of 0.2 mol / L.

[0025] 3. Preparation of flaky B-type carbonate-type apatite: Weigh 0.6 g of calcium carbonate powder, put it in 100 mL of phosphate buffer solution, heat it with non-pulse continuous microwave, power range 0~1200W, react at 80°C 5 min. The precipitate was collected by filtration, washed several times with deionized water, and dried in an oven at 80°C.

[0026] 4. Test: After scanning electron microscope inspection, the particle shape is flake. X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray energy spectrometer detection showed that the sample was B-type carbonate-type apa...

Embodiment 2

[0028] 1. The fish bone is mechanically ground to form a fish bone powder with a particle size of about 2 μm.

[0029] 2. Dissolve sodium dihydrogen phosphate and disodium hydrogen phosphate in distilled water to prepare a phosphate buffer solution with a pH of 8.0 and a total concentration of phosphate of 0.3 mol / L.

[0030] 3. Preparation of flaky B-type carbonate-type apatite: Weigh 0.6 g of fish bone powder, of which the calcium carbonate content is 93%, put it in 100 mL of phosphate buffer solution, and heat it with pulsed microwave at a power of 100W , react at 100°C for 10 min. The precipitate was collected by filtration, washed several times with deionized water, and dried in an oven at 80°C.

[0031] 4. Test: The shape of the sample is sheet-like and the crystallinity is low by scanning electron microscopy; X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray energy spectrometer detection show that the sample is B-type carbonate-type apatite, Ca / P ...

Embodiment 3

[0033] 1. First use a brush to remove impurities on the surface of the shell, and rinse with tap water. After sanding off the shell layer and prism layer, ultrasonication was performed for 5 min, and then cleaned with deionized water and absolute ethanol, and dried in a blast drying oven at 60 °C for 48 h to obtain a shiny shell nacre.

[0034] 2. Dissolve potassium dihydrogen phosphate and dipotassium hydrogen phosphate in distilled water to prepare a phosphate buffer solution with pH=10 and total phosphate concentration of 0.5 mol / L.

[0035] 3. Preparation of flaky B-type carbonate-type apatite: Weigh 2.0 g of shell nacre (in which calcium carbonate content is 98%), put it in 300 mL of phosphate buffer solution, and heat it with pulsed microwave at a power of 100W, 20 min at 100°C. The precipitate was collected by filtration, washed several times with deionized water, and dried in an oven at 80°C.

[0036] 4. Test: X-ray diffraction, Fourier transform infrared spectroscop...

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Abstract

The invention relates to the technical field of inorganic nonmetallic materials and medical materials and discloses a preparation method of slice-shaped B type carbonate phosphorite. The preparation method comprises the following steps of: placing calcium carbonate or calcium carbonate-containing biological mineral substances comprising shells, corals, fishbone, cuttle bones and the like in a phosphate buffer solution, and then rapidly transforming to a B type carbonate phosphorite material by microwave treatment. The Ca / P molar ratio of the slice-shaped B type carbonate phosphorite material obtained in the method is 1.30-1.67, particles are in a slice shape so that the degree of crystallization is lower, and the slice-shaped B type carbonate phosphorite material has the advantages of favorable bioactivity, biocompatibility and biodegradation and wide application prospect in the field of bone restoring materials. The method has the advantages of high reaction speed, mild reaction condition, simple production process, less equipment investment and environmental protection, and because no high temperature and pressure is needed in the method, the safety and the energy consumption are both obviously improved.

Description

technical field [0001] The invention relates to the technical field of inorganic non-metallic materials and medical materials, in particular to a method for preparing flaky B-type carbonate-type apatite. Background technique [0002] Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 HA for short] is the main inorganic component of hard tissues such as bones and teeth in the human body. It has the advantages of good biocompatibility, biological activity, no toxic side effects, and no immune response. HA crystal is a hexagonal crystal system, which belongs to L 6 PC symmetrical type and P6 3 / m space group, its structure is a hexagonal prism, and c The face perpendicular to the axis is a hexagon, a , b Shaft angle 120 ○ . HA unit cell parameters a =0.943~1.938 nm, c =0.686~0.688 nm, the unit cell contains 10 Ca 2+ , 6 POs 4 3- and 2 OH - . The structure of HA in organisms is complex, and in most cases the composition of minerals is impure, and calcium ions are often lack...

Claims

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Application Information

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IPC IPC(8): C01B25/32
Inventor 郭亚平郭亚军姚勇波褚联峰
Owner SHANGHAI NORMAL UNIVERSITY
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