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Composition containing bifidobacterium and application thereof

A bifidobacterium and composition technology, applied in the field of bifidobacterium-containing composition and bifidobacteria products, can solve the problems of the decrease of viable bacteria content, so as to promote the proliferation of bacteria, shorten the production cycle, and inhibit the change of physical and chemical properties Effect

Inactive Publication Date: 2011-04-20
菲伯纳生物医药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of highly active bifidobacterium and its preparation method, to solve the problem that the content of live bacteria in the products existing in bifidobacterium products decreases during storage and consumption

Method used

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  • Composition containing bifidobacterium and application thereof
  • Composition containing bifidobacterium and application thereof
  • Composition containing bifidobacterium and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: the preparation of bifidobacteria powder

[0042] 1. High density culture

[0043] (1) Strain activation: Under sterile conditions, pick the bacteria in the ampoule tube and inoculate them on liquid medium and agar plate, culture anaerobically at 37°C for 48 hours, and activate continuously for 3 generations to obtain the activated strain .

[0044] Wherein, the preparation method for the bifidobacterium culture medium of the present invention is as follows: tryptone 5.0g, yeast extract 10.0g, soybean peptone 5.0g, glucose 10.0g, L-cysteine ​​hydrochloride 0.5g, spitone Warm 801.0mL, saline solution 40mL, add water to make up to 1000mL, adjust the pH to 6.8-7.0, and sterilize at 121°C for 20min. The composition of the salt solution is: calcium chloride 0.2g, potassium dihydrogen phosphate 1.0g, magnesium sulfate 0.48g, sodium bicarbonate 10.0g, dipotassium hydrogen phosphate 1.0g, sodium chloride 2.0g, add water to 1000mL.

[0045] (2) Seed culture: Inocu...

Embodiment 2

[0060] Embodiment 2: composition formula

[0061]

[0062]

[0063] The components of the composition are mixed according to the dosage in the above table, and made into capsules, 0.25g / capsule, 4 capsules each time, twice a day; made into granules, 1g / bag, 1 bag each time, twice a day.

Embodiment 3

[0064] Embodiment 3: Effect on the blood lipid level of hyperlipidemia model rats

[0065] Animal grouping and administration: 50 male SD rats, weighing 190-220 g, were randomly divided into 5 groups, namely normal control group, high-fat model group, low-, medium-, and high-dose groups of the composition, with 10 rats in each group. Except the normal control group, the rats were given 10g of high-fat diet (1.5% cholesterol, 10% lard, 0.3% bile salt, 10% egg yolk powder, 0.2% methylthiouracil, 78% common feed) per 100g body weight. , fed for 15 days, after the successful establishment of the hyperlipidemia model was confirmed by body weight and blood lipid detection, 0.10, 0.25, and 0.50 g / kg of the composition were administered to the rats in the low, middle, and high dose groups of the composition by intragastric administration, respectively, Rats in the normal control group and the negative control group were given the same amount of distilled water by intragastric administ...

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Abstract

The invention discloses a composition containing bifidobacterium and application thereof. The composition is characterized by being prepared by mixing the bifidobacterium subjected to high-density culture and dual-layer embedding, oligosaccharide, vitamins, metal elements and auxiliary materials, wherein the composition containing the bifidobacterium comprises the components of 0.01-10 percent of bifidobacterium, 10-50 percent of oligosaccharide, 0.01-10 percent of vitamins, 0.01-10 percent of metal elements and the balance of auxiliary materials. The composition containing bifidobacterium has the functions of assisting in reducing blood fat and resisting oxidation, can be prepared into capsules, electuary, granules, tablets and the other forms and can be applied to the fields of foods, health-care products and medicines.

Description

technical field [0001] The invention relates to a bifidobacterium product, in particular to a bifidobacterium-containing composition and its application, and belongs to the technical field of preparation of bifidobacteria products. The function of blood lipid and anti-oxidation can be made into capsules, granules, granules, tablets and other forms, and can be used in the fields of food, health care products and medicines. Background technique [0002] Aging is a complex dynamic process in the life cycle that shows the deterioration of body function over time until death. During this process, the body's metabolism changes, and each system undergoes corresponding degenerative changes, leading to an upward trend in the morbidity and mortality of aging-related chronic diseases. If one or several kinds of lipid metabolism disorders in the body lead to obvious abnormalities of one or several lipid components in the blood, hyperlipidemia will be caused, which is a chronic disease ...

Claims

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Application Information

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IPC IPC(8): A23L1/302A23L1/304A23L1/303A61K35/74A61P3/06A61P39/06C12N11/04A61K31/702A61K31/07A61K31/51A61K31/714A61K31/525A61K31/4415A61K31/375A61K31/59A61K31/355A61K33/30A61K33/26A61K33/06C12R1/01A23L33/16A61K35/745
Inventor 曾星
Owner 菲伯纳生物医药有限责任公司
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