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Nux vomica capsules for treating myasthenia gravis and preparation process thereof

A technology of myasthenia gravis and preparation process, which is applied in the direction of capsule delivery, medical preparations containing active ingredients, muscular system diseases, etc., and can solve the problem of narrow application range, no treatment method and short action time of plasma exchange and thymectomy To achieve the effect of ensuring the safety of clinical medication, good patient compliance, and strong application

Inactive Publication Date: 2013-06-12
ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Modern medicine often uses anticholinesterase drugs to improve symptoms, but the action time is short and the curative effect is extremely unstable; although hormone drugs and immunosuppressants have certain curative effects, they have large adverse reactions and are prone to relapse after drug withdrawal; plasma exchange method Thymectomy and thymectomy have a narrow range of applications, and there are certain risks, so far there is still no effective treatment

Method used

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  • Nux vomica capsules for treating myasthenia gravis and preparation process thereof
  • Nux vomica capsules for treating myasthenia gravis and preparation process thereof
  • Nux vomica capsules for treating myasthenia gravis and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Processing of Nuxychnium Capsules

[0031] Nymph 20kg Sesame Oil 18kg Liuyisan 15kg

[0032] (1) Nuxychnya raw medicinal material, remove impurities, sieve to remove ash, soak in water for 10 days until there is no hard core inside, remove, scrape off fur, dry slightly, cut into thin slices, and dry in the air. (2) Heat sesame oil in a pan, add dried flakes, fry until yellow-brown, take out, sprinkle Liuyisan evenly, absorb sesame oil, rinse Liuyisan with clean water, dry in the sun, and set aside. (3) Beat into fine powder with a 100-mesh sieve, sterilize, and fill into capsules.

Embodiment 2

[0034] Quality Control of Nuxebra Capsules

[0035] (1) This product is a hard capsule, and each capsule contains 0.2g of roasted nuyon seed powder, and the difference in the filling amount should be within 10%.

[0036] (2) Identification: Take 0.5g of the contents of this product, add 0.5ml of concentrated ammonia test solution and mix well, add 5ml of chloroform-ethanol (10:1) mixed solution, seal it tightly, shake for 5 minutes, and let it stand for 2 hours , filtered, and the filtrate was used as the test solution. Take another strychnine reference substance and strychnine reference substance, add chloroform to make a mixed solution containing 2mg per 1ml, as the reference substance solution. Test according to thin-layer chromatography (Appendix VIIB of "Chinese Pharmacopoeia" 2005 edition), draw 10 μl of each of the above two solutions, spot them on the same silica gel G plate respectively, and use toluene-acetone-ethanol-concentrated ammonia test solution (4: 5∶0.6∶0....

Embodiment 3

[0049] Clinical Observation on Myasthenia Gravis Treated by Nuxynum Capsules

[0050] (1) Case selection and group observation There were 58 cases, 36 males and 22 females; the youngest was 20 years old, the oldest was 65 years old; the shortest course of disease was 24 days, and the longest was 21 years; 34 cases of ocular muscle type, There were 2 cases of medullary type, 4 cases of spinal type, and 18 cases of generalized type. They were divided into 31 cases in Nuxebra Capsules group and 27 cases in Pyridostigmine bromide control group. There was no significant difference between the two groups (age, gender, disease duration) (p>0.05).

[0051] (2) Therapeutic medication treatment group: treated with Nuxebra Capsules, 2 capsules each time, orally 3 times a day, if the patient was taking pyridostigmine bromide, prednisone or acetone, continue to take them, wait until immediately After taking Qianzi Capsules for 10-20 days, gradually reduce the dosage until completely disc...

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Abstract

The invention provides Chinese medicinal nux vomica capsules for treating myasthenia gravis, which is characterized in that: processing procedures of water soaking, unhairing, frying and the like are adopted, so that the toxicity of a main active ingredient, namely strychnine is obviously reduced. The preparation process is strict and standard, easy to operate, and controllable in quality and canensure the quality stability and clinical administration safety of the nux vomica capsules. Through years of clinical observation, the capsules have satisfying curative effects and small toxic and side effects, can control slight myasthenia gravis through a single medicine, can treat severe myasthenia gravis cooperatively, can obviously reduce the using amount of western medicines and the relatedtoxic and side effects, and improve the curative effects, so the capsules have good development and clinical application prospect.

Description

1. Technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a medicine for treating myasthenia gravis, a refractory disease of the nervous system, and a production process thereof, in particular to Chinese medicine Nuxe chinensis and suitable medicinal auxiliary materials prepared according to a certain ratio. The capsules are used for the treatment of different degrees of myasthenia gravis such as eye muscle damage, limb weakness, chewing weakness, dysphagia, and muscle atrophy. 2. Background technology [0002] Myasthenia gravis (Myasthemina Gravis, MG) belongs to the category of "atrophy" in traditional Chinese medicine. It is an autoimmune nerve-muscle junction post-synaptic membrane lesion related to the thymus. The clinical features are skeletal muscle weakness and easy fatigue. Tendency to remission and relapse, some patients have a family history. Mild patients only have symptoms of eye muscle damage such as ptosis o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/56A61K9/48A61P21/04A61K131/00
Inventor 钱松祥裘昌林许家鸾
Owner ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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